WormBase Tree Display for Gene: WBGene00001511
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| WBGene00001511 | Evidence | Paper_evidence | WBPaper00005604 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | CHROMOSOME_II | ||||||
| Identity | Version | 2 | |||||||
| Name | CGC_name | fzy-1 | Person_evidence | WBPerson533 | |||||
| Sequence_name | ZK177.6 | ||||||||
| Molecular_name | ZK177.6 | ||||||||
| ZK177.6.1 | |||||||||
| CE26338 | |||||||||
| ZK177.6.2 | |||||||||
| Other_name | cdc-20 | ||||||||
| CELE_ZK177.6 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | fzy-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 17 Feb 2017 11:43:58 | WBPerson2970 | Name_change | Other_name | cdc-20 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | fzy | ||||||||
| Allele (44) | |||||||||
| Strain | WBStrain00023982 | ||||||||
| WBStrain00035582 | |||||||||
| WBStrain00000069 | |||||||||
| WBStrain00022412 | |||||||||
| WBStrain00022424 | |||||||||
| WBStrain00054967 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (23) | |||||||||
| Contained_in_operon | CEOP2188 | ||||||||
| Ortholog (40) | |||||||||
| Paralog | WBGene00001510 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | fzy-1 encodes an ortholog of S. cerevisiae Cdc20p that is required for themetaphase-to-anaphase transition, the deposition of extra meioticchromosomes to polar bodies, and postembryonic vulval development; on thebasis of orthology, FZY-1 is predicted to regulate anaphase-promotingcomplex (APC); FZY-1 protein is found in early embryonic cells atprometaphase and metaphase of mitosis and meiosis I, being localized tocondensed chromosomes in prometaphase, and chromosomes on the metaphaseplate during metaphase; FZY-1 binds IFY-1 and MDF-2 in yeast two-hybridexperiments; the missense fzy-1(h1983) mutation suppresses the lethalphenotype of mdf-1; fzy-1(RNAi) animals have vulval defects reflectingthose seen in homozygotes for mat-3(ku233), whereas mat-3(ku233) ispartly suppressed by RNAi of the fzy-1 paralog fzr-1. | Paper_evidence | WBPaper00005604 | |||||
| WBPaper00006026 | |||||||||
| WBPaper00024252 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 23 Aug 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable anaphase-promoting complex binding activity and ubiquitin ligase activator activity. Involved in asymmetric cell division; meiotic cell cycle; and polarity specification of anterior/posterior axis. Located in condensed chromosome and cytoplasm. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 109. Is an ortholog of human CDC20 (cell division cycle 20) and FZR1 (fizzy and cell division cycle 20 related 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0070378 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:24824) | ||||
| EFO:MONDO:0014769 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1723) | ||||||
| Molecular_info | Corresponding_CDS | ZK177.6 | |||||||
| Corresponding_transcript | ZK177.6.1 | ||||||||
| ZK177.6.2 | |||||||||
| Other_sequence (12) | |||||||||
| Associated_feature | WBsf644200 | ||||||||
| WBsf221288 | |||||||||
| WBsf221289 | |||||||||
| Experimental_info | RNAi_result (19) | ||||||||
| Expr_pattern | Expr2279 | ||||||||
| Expr13904 | |||||||||
| Expr15179 | |||||||||
| Expr1021760 | |||||||||
| Expr1030908 | |||||||||
| Expr1162687 | |||||||||
| Expr2011928 | |||||||||
| Expr2030165 | |||||||||
| Drives_construct | WBCnstr00036898 | ||||||||
| WBCnstr00039494 | |||||||||
| WBCnstr00042032 | |||||||||
| Construct_product | WBCnstr00036898 | ||||||||
| WBCnstr00039494 | |||||||||
| WBCnstr00042032 | |||||||||
| Antibody | WBAntibody00000592 | ||||||||
| WBAntibody00002813 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (181) | |||||||||
| Interaction (121) | |||||||||
| Map_info | Map | II | Position | -1.26997 | Error | 0.010345 | |||
| Positive | Positive_clone | ZK177 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4184 | |||||||
| 4331 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (34) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
