WormBase Tree Display for Gene: WBGene00001510

WBGene00001510 Evidence: Paper_evidence: WBPaper00005137
  SMap: S_parent: Sequence: ZK1307
  Identity: Version: 1
    Name: CGC_name: fzr-1 Person_evidence: WBPerson634
      Sequence_name: ZK1307.6
      Molecular_name: ZK1307.6a
        ZK1307.6a.1
        CE01695
        ZK1307.6b
        CE54285
        ZK1307.6b.1
      Other_name: CELE_ZK1307.6 Accession_evidence: NDB BX284602
      Public_name: fzr-1
    DB_info: Database: AceView gene 2J930
        WormQTL gene WBGene00001510
        SignaLink protein WBGene00001510
        WormFlux gene WBGene00001510
        NDB locus_tag CELE_ZK1307.6
        Panther gene CAEEL|WormBase=WBGene00001510|UniProtKB=Q09649
          family PTHR19918
        NCBI gene 174516
        RefSeq protein NM_063674.7
            NM_001395804.1
        TrEMBL UniProtAcc Q09649
            A0A7R9SW82
        UniProt_GCRP UniProtAcc A0A7R9SW82
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:24 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: fzr
    Allele (77)
    Strain: WBStrain00026519
      WBStrain00031374
      WBStrain00034616
      WBStrain00054813
    RNASeq_FPKM (74)
    GO_annotation: 00055337
      00055338
      00055339
      00055340
      00108832
      00108833
      00108834
    Ortholog (41)
    Paralog: WBGene00001511 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: fzr-1 encodes a WD repeat-containing protein homologous to Cdh1/Hct1/FZR (OMIM:603619), a regulatory subunit of the anaphase-promoting complex/cyclosome (APC/C) required for anaphase initiation and exit from mitosis; FZR-1 is required for fertility, and also functions redundantly with lin-35/Rb to for normal embryogensis and control of postembryonic cell proliferation; FZR-1 probably regulates the levels of G1 cyclins, degradation of which is critical for G1 arrest. Paper_evidence: WBPaper00005137
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable anaphase-promoting complex binding activity and ubiquitin-protein transferase activator activity. Involved in cell cycle G1/S phase transition and regulation of cell division. Located in cytoplasm and nucleus. Expressed in intestinal cell; seam cell; ventral cord blast cell; and vulval precursor cell. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: ZK1307.6a
      ZK1307.6b
    Corresponding_transcript: ZK1307.6a.1
      ZK1307.6b.1
    Other_sequence (29)
    Associated_feature: WBsf650442
      WBsf665958
      WBsf665959
      WBsf665960
      WBsf989104
      WBsf223678
      WBsf223679
  Experimental_info: RNAi_result: WBRNAi00114778 Inferred_automatically: RNAi_primary
      WBRNAi00080526 Inferred_automatically: RNAi_primary
      WBRNAi00082047 Inferred_automatically: RNAi_primary
      WBRNAi00086810 Inferred_automatically: RNAi_primary
      WBRNAi00062681 Inferred_automatically: RNAi_primary
      WBRNAi00059224 Inferred_automatically: RNAi_primary
      WBRNAi00086809 Inferred_automatically: RNAi_primary
      WBRNAi00086819 Inferred_automatically: RNAi_primary
      WBRNAi00086820 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr11864
      Expr12120
      Expr1023816
      Expr1030907
      Expr1162643
      Expr2011927
      Expr2030164
    Drives_construct: WBCnstr00019682
      WBCnstr00020199
      WBCnstr00020683
      WBCnstr00036899
    Construct_product: WBCnstr00001338
      WBCnstr00020199
      WBCnstr00020683
      WBCnstr00036899
    Microarray_results (24)
    Expression_cluster (104)
    Interaction (112)
  Map_info: Map: II Position: 1.62189 Error: 0.001268
    Positive: Positive_clone: ZK1307 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4330
    Pseudo_map_position
  Reference (32)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene