WormBase Tree Display for Gene: WBGene00018877
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| WBGene00018877 | SMap | S_parent | Sequence | F55D10 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | aman-1 | Paper_evidence | WBPaper00027768 | |||||
| Sequence_name | F55D10.1 | ||||||||
| Molecular_name | F55D10.1 | ||||||||
| F55D10.1.1 | |||||||||
| CE28456 | |||||||||
| Other_name | CELE_F55D10.1 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | aman-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:00 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 05 Jan 2007 17:07:18 | WBPerson1847 | Name_change | CGC_name | aman-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | aman | ||||||||
| Allele (87) | |||||||||
| Strain | WBStrain00001773 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (11) | |||||||||
| Ortholog (46) | |||||||||
| Paralog | WBGene00010284 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00018594 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | aman-1 encodes an ortholog of human lysosomal mannosidase (MAN2B1;OMIM:609458, mutated in alpha-mannosidosis); AMAN-1 is predicted to helpdigest glycoproteins by removing mannose residues from their N-linkedoligosaccharides; AMAN-1 has seven predicted N-glycosylation sites;AMAN-1 is biochemically active in vitro, has optimal activity at pH4-4.5, and is unaffected by Co(II); however, AMAN-1 expressed in Pichiapastoris lacks normal activity, perhaps because it requires othersubunits in vivo; aman-1 is expressed in neurons and intestine. | Paper_evidence | WBPaper00006525 | |||||
| WBPaper00027768 | |||||||||
| Curator_confirmed | WBPerson1823 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 14 Mar 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable alpha-mannosidase activity. Predicted to be involved in mannose metabolic process. Predicted to be located in lysosome. Human ortholog(s) of this gene implicated in alpha-mannosidosis. Is an ortholog of human MAN2B1 (mannosidase alpha class 2B member 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:3413 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6826) | ||||
| Molecular_info | Corresponding_CDS | F55D10.1 | |||||||
| Corresponding_transcript | F55D10.1.1 | ||||||||
| Other_sequence (44) | |||||||||
| Associated_feature | WBsf648039 | ||||||||
| WBsf662713 | |||||||||
| WBsf1005046 | |||||||||
| WBsf1005047 | |||||||||
| WBsf1005048 | |||||||||
| WBsf1022842 | |||||||||
| WBsf235625 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00015725 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00076484 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00048493 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00081081 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram257 | ||||||||
| Expr6204 | |||||||||
| Expr1011721 | |||||||||
| Expr1038146 | |||||||||
| Expr1152284 | |||||||||
| Expr2009320 | |||||||||
| Expr2027556 | |||||||||
| Drives_construct | WBCnstr00002587 | ||||||||
| WBCnstr00026220 | |||||||||
| Construct_product | WBCnstr00009554 | ||||||||
| WBCnstr00026220 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (176) | |||||||||
| Interaction | WBInteraction000049245 | ||||||||
| WBInteraction000253230 | |||||||||
| WBInteraction000371124 | |||||||||
| WBInteraction000463533 | |||||||||
| WBInteraction000573870 | |||||||||
| Map_info | Map | X | Position | -6.75069 | |||||
| Positive | Positive_clone | F55D10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00027768 | ||||||||
| WBPaper00029024 | |||||||||
| WBPaper00034662 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00055090 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
