WormBase Tree Display for Gene: WBGene00001840
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| WBGene00001840 | SMap | S_parent | Sequence | C26D10 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | hel-1 | |||||||
| Sequence_name | C26D10.2 | ||||||||
| Molecular_name | C26D10.2a | ||||||||
| C26D10.2a.1 | |||||||||
| CE03025 | |||||||||
| C26D10.2b | |||||||||
| Other_name | hel | Accession_evidence | EMBL | U08102 | |||||
| CELE_C26D10.2 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | hel-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | hel | ||||||||
| Allele (30) | |||||||||
| Strain | WBStrain00001557 | ||||||||
| WBStrain00002229 | |||||||||
| WBStrain00035692 | |||||||||
| WBStrain00037647 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (27) | |||||||||
| Ortholog (40) | |||||||||
| Paralog (37) | |||||||||
| Structured_description | Concise_description | hel-1 encodes an ortholog of human 56-kD U2AF65 associated protein (UAP56)that is required for exporting mRNAs from the nucleus; unlike animals withRNAi against several other splicing factors, hel-1(RNAi) animals fail toexport transgenic GFP mRNA from the nucleus; conversely, hel-1overexpression is lethal, with failed transgene expression as well. | Paper_evidence | WBPaper00005959 | |||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 06 Sep 2006 00:00:00 | ||||||||
| Automated_description | Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in determination of adult lifespan; nuclear mRNA surveillance; and positive regulation of gene expression. Located in nucleus. Part of transcription regulator complex. Expressed in hypodermis; intestine; and neurons. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Is an ortholog of human DDX39A (DExD-box helicase 39A). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9744 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13917) | ||||
| Molecular_info | Corresponding_CDS | C26D10.2a | |||||||
| Corresponding_CDS_history | C26D10.2:wp92 | ||||||||
| C26D10.2:wp96 | |||||||||
| C26D10.2b:wp96 | |||||||||
| C26D10.2b:wp250 | |||||||||
| Corresponding_transcript | C26D10.2b | ||||||||
| C26D10.2a.1 | |||||||||
| Other_sequence (241) | |||||||||
| Associated_feature | WBsf650313 | ||||||||
| WBsf650314 | |||||||||
| WBsf665781 | |||||||||
| WBsf665782 | |||||||||
| WBsf665783 | |||||||||
| WBsf223482 | |||||||||
| WBsf223483 | |||||||||
| WBsf223484 | |||||||||
| Experimental_info | RNAi_result (38) | ||||||||
| Expr_pattern | Chronogram952 | ||||||||
| Expr5341 | |||||||||
| Expr5342 | |||||||||
| Expr12409 | |||||||||
| Expr1026321 | |||||||||
| Expr1031084 | |||||||||
| Expr1145299 | |||||||||
| Expr2012395 | |||||||||
| Expr2030631 | |||||||||
| Drives_construct | WBCnstr00002397 | ||||||||
| WBCnstr00004329 | |||||||||
| WBCnstr00020985 | |||||||||
| Construct_product | WBCnstr00020985 | ||||||||
| Antibody | WBAntibody00000651 | ||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (154) | |||||||||
| Interaction (249) | |||||||||
| Map_info | Map | II | Position | 0.761021 | Error | 0.000763 | |||
| Positive | Positive_clone | C26D10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4399 | |||||||
| 4274 | |||||||||
| 4548 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (11) | |||||||||
| Remark | Pseudogene tag removed because the corresponding sequence object for this gene has not been annotated as a pseudogene. This discrepancy may reflect that the sequence object was once a pseudogene and has subsequently been converted into a real gene (without this Locus object being updated). Alternatively it may be that this gene is a pseudogene in another C. elegans strain, but not in the sequenced N2 strain. [krb 030806] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
