WormBase Tree Display for Gene: WBGene00000265
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| WBGene00000265 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | K04C2 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | brd-1 | Person_evidence | WBPerson1551 | |||||
| Sequence_name | K04C2.4 | ||||||||
| Molecular_name | K04C2.4 | ||||||||
| K04C2.4.1 | |||||||||
| CE44987 | |||||||||
| Other_name | K04C2.a | Curator_confirmed | WBPerson1983 | ||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| K04C2.b | Curator_confirmed | WBPerson1983 | |||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_K04C2.4 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | brd-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | brd | ||||||||
| Allele (58) | |||||||||
| Strain | WBStrain00032124 | ||||||||
| WBStrain00035955 | |||||||||
| WBStrain00006440 | |||||||||
| WBStrain00054769 | |||||||||
| WBStrain00054770 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (25) | |||||||||
| Ortholog (29) | |||||||||
| Paralog | WBGene00018993 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| WBGene00018019 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| Structured_description | Concise_description | brd-1 encodes an ortholog of the BRCA1-associating protein BARD1(OMIM:601593), associated with susceptibility to breast cancer; BRD-1forms a heterodimer with BRC-1, which constitutes an E3 ubiquitin ligase;after irradiation, the DNA checkpoint proteins ATL-1 and MRE-11 arerequired for BRC-1/BRD-1 heterodimers to associate with the E2ubiqutin-conjugating enzyme LET-70/Ubc5 and with RAD-51, and toubiquitylate damaged chromatin; BRD-1 and BRC-1 bind one another, probablythrough their N-terminal RING domains, in yeast two-hybrid experiments andpull-down assays; BRC-1/BRD-1 heterodimers may interact with RAD-51 andother proteins via mutual binding to UBC-9; brd-1(RNAi) animals haveexcess chromosomal nondisjunction, abnormally high levels ofCEP-1-dependent germ cell apoptosis (both with and withoutgamma-irradiation) and hypersensitivity to gamma-irradiation (e.g.,abnormal sterility after irradiation); BRD-1 autoubiquitylation probablyactivates the BRC-1/BRD-1 heterodimer; BRD-1 binds SMT-3 (a Sumo homolog)and TAC-1; brd-1 is genetically dispensable for the induction of nuclearATL-1 foci by gamma-irradiation or hydroxyurea. | Paper_evidence | WBPaper00004103 | |||||
| WBPaper00006342 | |||||||||
| WBPaper00026962 | |||||||||
| WBPaper00027343 | |||||||||
| WBPaper00027765 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 25 Aug 2006 00:00:00 | ||||||||
| Automated_description | Enables ubiquitin protein ligase activity. Involved in DNA repair and protein ubiquitination. Part of BRCA1-BARD1 complex. Human ortholog(s) of this gene implicated in breast cancer and ovarian cancer. Is an ortholog of human BARD1 (BRCA1 associated RING domain 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:2394 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:952) | ||||
| DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:952) | ||||||
| Molecular_info | Corresponding_CDS | K04C2.4 | |||||||
| Corresponding_CDS_history | K04C2.4:wp88 | ||||||||
| Corresponding_transcript | K04C2.4.1 | ||||||||
| Other_sequence | CJC08333_1 | ||||||||
| CRC02881_1 | |||||||||
| CBC17245_1 | |||||||||
| Associated_feature | WBsf651148 | ||||||||
| WBsf992893 | |||||||||
| WBsf1015167 | |||||||||
| Experimental_info | RNAi_result (15) | ||||||||
| Expr_pattern | Expr3996 | ||||||||
| Expr13974 | |||||||||
| Expr13975 | |||||||||
| Expr1025246 | |||||||||
| Expr1030171 | |||||||||
| Expr1153595 | |||||||||
| Expr1200382 | |||||||||
| Expr1200383 | |||||||||
| Expr2009650 | |||||||||
| Expr2027889 | |||||||||
| Drives_construct | WBCnstr00000419 | ||||||||
| WBCnstr00017299 | |||||||||
| WBCnstr00017302 | |||||||||
| Construct_product | WBCnstr00000419 | ||||||||
| WBCnstr00017299 | |||||||||
| WBCnstr00017302 | |||||||||
| Regulate_expr_cluster | WBPaper00063930:BRD-1_interacting | ||||||||
| Antibody | WBAntibody00001125 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (178) | |||||||||
| Interaction (58) | |||||||||
| Map_info | Map | III | Position | -0.90773 | Error | 0.000588 | |||
| Positive | Positive_clone | K04C2 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (35) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
