WormBase Tree Display for Gene: WBGene00045383

WBGene00045383 SMap: S_parent: Sequence: C25A1
  Identity: Version: 2
    Name: CGC_name: sup-46 Paper_evidence: WBPaper00028588
          Person_evidence: WBPerson261
      Sequence_name: C25A1.4
      Molecular_name: C25A1.4
        C25A1.4.1
        CE08369
      Other_name: CELE_C25A1.4 Accession_evidence: NDB BX284601
      Public_name: sup-46
    DB_info: Database: NDB locus_tag CELE_C25A1.4
        Panther gene CAEEL|WormBase=WBGene00045383|UniProtKB=Q9XVS2
          family PTHR23003
        NCBI gene 172881
        RefSeq protein NM_060276.6
        TREEFAM TREEFAM_ID TF313406
        TrEMBL UniProtAcc Q9XVS2
        UniProt_GCRP UniProtAcc Q9XVS2
    Species: Caenorhabditis elegans
    History: Version_change: 1 12 Apr 2007 13:43:01 WBPerson2970 Event: Created
        2 01 Aug 2017 12:21:15 WBPerson2970 Event: Acquires_merge: WBGene00007706
              Name_change: Sequence_name: C25A1.4
      Acquires_merge: WBGene00007706
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sup
    Allele (35)
    Strain: WBStrain00040607
      WBStrain00040604
      WBStrain00040606
      WBStrain00005633
      WBStrain00005630
      WBStrain00051098
    RNASeq_FPKM (74)
    GO_annotation (11)
    Ortholog (43)
    Structured_description: Concise_description: sup-46, when mutated, suppresses the lethality of gna-2(qa705); however, the three suppressor alleles (qa707, qa708, qa709) require a gna-1(+) background for suppression, suggesting that uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) synthesis is indispensable for embryonic development, and that SUP-46 normally inhibits GNA-1 in tissues where GNA-2 is normally active. Paper_evidence: WBPaper00028588
          Curator_confirmed: WBPerson567
          Date_last_updated: 20 Jul 2017 00:00:00
      Automated_description: Predicted to enable mRNA binding activity. Predicted to be located in cytoplasm and nucleus. Expressed in germ cell and somatic cell. Human ortholog(s) of this gene implicated in colorectal carcinoma and leiomyoma. Is an ortholog of human HNRNPM (heterogeneous nuclear ribonucleoprotein M) and MYEF2 (myelin expression factor 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:127 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5046)
      DOID:0080199 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5046)
  Molecular_info: Corresponding_CDS: C25A1.4
    Corresponding_transcript: C25A1.4.1
    Other_sequence (55)
    Associated_feature: WBsf649553
      WBsf664839
      WBsf984930
      WBsf984931
      WBsf984932
      WBsf1010496
      WBsf1010497
      WBsf220200
      WBsf220201
      WBsf220202
  Experimental_info: RNAi_result: WBRNAi00082502 Inferred_automatically: RNAi_primary
      WBRNAi00082575 Inferred_automatically: RNAi_primary
      WBRNAi00061737 Inferred_automatically: RNAi_primary
      WBRNAi00102167 Inferred_automatically: RNAi_primary
      WBRNAi00029172 Inferred_automatically: RNAi_primary
      WBRNAi00116904 Inferred_automatically: RNAi_primary
      WBRNAi00041144 Inferred_automatically: RNAi_primary
      WBRNAi00003012 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr15106
      Expr1020053
      Expr1033335
      Expr1145177
      Expr2001062
      Expr2019281
    Drives_construct: WBCnstr00033542
    Construct_product: WBCnstr00033542
    Microarray_results (23)
    Expression_cluster (123)
    Interaction (38)
  Map_info: Map: I Position: 4.71731
    Positive: Positive_clone: C25A1 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00051515
    WBPaper00055090
    WBPaper00064339
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene