WormBase Tree Display for Gene: WBGene00045383

WBGene00045383 SMap: S_parent: Sequence: C25A1
  Identity: Version: 2
    Name: CGC_name: sup-46 Paper_evidence: WBPaper00028588
          Person_evidence: WBPerson261
      Sequence_name: C25A1.4
      Molecular_name: C25A1.4
        C25A1.4.1
        CE08369
      Other_name: CELE_C25A1.4 Accession_evidence: NDB BX284601
      Public_name: sup-46
    DB_info: Database: NDB locus_tag CELE_C25A1.4
        Panther gene CAEEL|WormBase=WBGene00045383|UniProtKB=Q9XVS2
          family PTHR23003
        NCBI gene 172881
        RefSeq protein NM_060276.6
        TREEFAM TREEFAM_ID TF313406
        TrEMBL UniProtAcc Q9XVS2
        UniProt_GCRP UniProtAcc Q9XVS2
    Species: Caenorhabditis elegans
    History: Version_change: 1 12 Apr 2007 13:43:01 WBPerson2970 Event: Created
        2 01 Aug 2017 12:21:15 WBPerson2970 Event: Acquires_merge: WBGene00007706
              Name_change: Sequence_name: C25A1.4
      Acquires_merge: WBGene00007706
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sup
    Allele (35)
    Strain: WBStrain00040607
      WBStrain00040604
      WBStrain00040606
      WBStrain00005633
      WBStrain00005630
      WBStrain00051098
    RNASeq_FPKM (74)
    GO_annotation (11)
    Ortholog (43)
    Structured_description: Concise_description: sup-46, when mutated, suppresses the lethality of gna-2(qa705); however, the three suppressor alleles (qa707, qa708, qa709) require a gna-1(+) background for suppression, suggesting that uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) synthesis is indispensable for embryonic development, and that SUP-46 normally inhibits GNA-1 in tissues where GNA-2 is normally active. Paper_evidence: WBPaper00028588
          Curator_confirmed: WBPerson567
          Date_last_updated: 20 Jul 2017 00:00:00
      Automated_description: Predicted to enable mRNA binding activity. Predicted to be located in cytoplasm and nucleus. Expressed in germ cell and somatic cell. Human ortholog(s) of this gene implicated in colorectal carcinoma and leiomyoma. Is an ortholog of human HNRNPM (heterogeneous nuclear ribonucleoprotein M) and MYEF2 (myelin expression factor 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:127 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5046)
      DOID:0080199 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:5046)
  Molecular_info: Corresponding_CDS: C25A1.4
    Corresponding_transcript: C25A1.4.1
    Other_sequence (55)
    Associated_feature: WBsf649553
      WBsf664839
      WBsf984930
      WBsf984931
      WBsf984932
      WBsf1010496
      WBsf1010497
      WBsf220200
      WBsf220201
      WBsf220202
  Experimental_info: RNAi_result: WBRNAi00082502 Inferred_automatically: RNAi_primary
      WBRNAi00082575 Inferred_automatically: RNAi_primary
      WBRNAi00061737 Inferred_automatically: RNAi_primary
      WBRNAi00102167 Inferred_automatically: RNAi_primary
      WBRNAi00029172 Inferred_automatically: RNAi_primary
      WBRNAi00116904 Inferred_automatically: RNAi_primary
      WBRNAi00041144 Inferred_automatically: RNAi_primary
      WBRNAi00003012 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr15106
      Expr1020053
      Expr1033335
      Expr1145177
      Expr2001062
      Expr2019281
    Drives_construct: WBCnstr00033542
    Construct_product: WBCnstr00033542
    Microarray_results (23)
    Expression_cluster: WBPaper00027057:DCR-1_interacting_embryo
      WBPaper00028451:Low_abundance_spermatogenesis_enriched
      WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00038289:oocyte_protein
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00042194:nhr-114(RNAi)_upregulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044760:germline_specific
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00045774:clk-1_downregulated
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00048644:germline_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050686:glp-1(e2141)_downregulated
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00051245:nucleus_specific
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053289:DREAM-target
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053308:SMG-2_associated_NMD(-)_upregulated_ClassI
      WBPaper00053388:dauer_regulated_Cluster6
      WBPaper00053615:SMO-1_target
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00055226:ADR-2_target_N2
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_downregulated_N2
      WBPaper00056868:P.aeruginosa_upregulated_smallRNA
      WBPaper00057288:iff-1(RNAi)_upregulated_protein
      WBPaper00058691:CFP-1_interacting_protein
      WBPaper00058691:WDR-5.1_interacting_protein
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059328:mrps-5(RNAi)_upregulated_protein
      WBPaper00059471:EGL-43_interacting
      WBPaper00059605:MUT-16_interacting
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00059763:neuron_expressed
      WBPaper00060014:set-2(tm1630)_upregulated
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061340:SMD
      WBPaper00061466:nath-10(icb102)_upregulated
      WBPaper00061479:HDA-1_interacting_protein
      WBPaper00061527:cids-2_2203-attf-2_2451
      WBPaper00061527:npp-6-mtr-4_21425
      WBPaper00061692:acivicin_downregulated
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064201:SNA-3_interacting
      WBPaper00064716:paraquat_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065373:sek-1(km4)_upregulated_Ref
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4489_group_3
      WBPaper00025032:cluster_22
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Enriched_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00030839:Embryo_A_Class
      WBPaper00030839:Embryo_Pan_Neuronal
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00032165:differentially_expressed_with_age_medoid_1
      WBPaper00034739:N2lessDR1350
      WBPaper00035905:FBF-1_Associated
      WBPaper00036286:Pattern_H
      WBPaper00039866:ClassComp_daf-19_upregulated
      WBPaper00040963:TA100_down
      WBPaper00040963:TA200_down
      WBPaper00040963:TA300_down
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045960:L1-L4-lethargus_downregulated
      WBPaper00045960:L4-lethargus_downregulated
      WBPaper00048624:hlh-25(ok1710)_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00053550:daf-19(m86)_upregulated_3-fold-embryo
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(53_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc6390]:intrinsic
    Interaction (38)
  Map_info: Map: I Position: 4.71731
    Positive: Positive_clone: C25A1 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00051515
    WBPaper00055090
    WBPaper00064339
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene