WormBase Tree Display for Gene: WBGene00010498

WBGene00010498 SMap: S_parent: Sequence: K02B12
  Identity: Version: 2
    Name: CGC_name: tnsl-1
      Sequence_name: K02B12.5
      Molecular_name: K02B12.5
        K02B12.5.1
        CE53745
      Other_name: CELE_K02B12.5 Accession_evidence: NDB BX284601
      Public_name: tnsl-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:51 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 13 Mar 2019 16:38:49 WBPerson1983 Name_change: CGC_name: tnsl-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: tnsl
    Allele (98)
    RNASeq_FPKM (74)
    Contained_in_operon: CEOP1480
    Ortholog (26)
    Paralog: WBGene00001495 Caenorhabditis elegans From_analysis: Panther
    Structured_description: Automated_description: Enriched in several structures, including Z1.p; body wall muscle cell; germ line; germline precursor cell; and male distal tip cell based on tiling array; RNA-seq; and microarray studies. Is affected by several genes including skn-1; daf-12; and hsf-1 based on tiling array; RNA-seq; and microarray studies. Is affected by thirteen chemicals including aldicarb; rotenone; and D-glucose based on microarray and RNA-seq studies. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Sponastrime type. Human TONSL enables histone binding activity and histone reader activity. Is predicted to encode a protein with the following domains: Ankyrin repeats (3 copies); Ankyrin repeat; Ankyrin repeats (many copies); Leucine-rich repeat domain superfamily; Ankyrin repeat-containing domain superfamily; Tetratricopeptide-like helical domain superfamily; Putative ankyrin repeat domain-containing protein 31; and Phosphorylation site. Is an ortholog of human TONSL (tonsoku like, DNA repair protein). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:5684 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7801)
  Molecular_info: Corresponding_CDS: K02B12.5
    Corresponding_CDS_history: K02B12.5:wp106
      K02B12.5:wp151
      K02B12.5:wp273
    Corresponding_transcript: K02B12.5.1
    Associated_feature: WBsf664571
      WBsf984455
      WBsf1010248
      WBsf219936
  Experimental_info: RNAi_result: WBRNAi00060445 Inferred_automatically: RNAi_primary
      WBRNAi00060447 Inferred_automatically: RNAi_primary
      WBRNAi00060446 Inferred_automatically: RNAi_primary
      WBRNAi00116965 Inferred_automatically: RNAi_primary
      WBRNAi00049663 Inferred_automatically: RNAi_primary
      WBRNAi00049665 Inferred_automatically: RNAi_primary
      WBRNAi00002397 Inferred_automatically: RNAi_primary
      WBRNAi00003894 Inferred_automatically: RNAi_primary
      WBRNAi00060448 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1025676
      Expr1034587
      Expr1153390
      Expr2004668
      Expr2022895
    Drives_construct: WBCnstr00031374
    Construct_product: WBCnstr00031374
    Microarray_results (18)
    Expression_cluster (125)
    Interaction: WBInteraction000450001
  Map_info: Map: I Position: 2.89794
    Positive: Positive_clone: K02B12 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00055090
    WBPaper00064339
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene