WormBase Tree Display for Gene: WBGene00004117
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| WBGene00004117 | SMap | S_parent | Sequence | F02E9 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | sin-3 | Paper_evidence | WBPaper00029394 | |||||
| Person_evidence | WBPerson107 | ||||||||
| Sequence_name | F02E9.4 | ||||||||
| Molecular_name | F02E9.4a | ||||||||
| F02E9.4a.1 | |||||||||
| CE33046 | |||||||||
| F02E9.4b | |||||||||
| CE40934 | |||||||||
| F02E9.4b.1 | |||||||||
| Other_name | pqn-28 | Person_evidence | WBPerson625 | ||||||
| CELE_F02E9.4 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | sin-3 | ||||||||
| DB_info | Database | WormQTL | gene | WBGene00004117 | |||||
| WormFlux | gene | WBGene00004117 | |||||||
| NDB | locus_tag | CELE_F02E9.4 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00004117|UniProtKB=A5JYW9 | |||||||
| family | PTHR12346 | ||||||||
| NCBI | gene | 172628 | |||||||
| RefSeq | protein | NM_059883.8 | |||||||
| NM_001128970.5 | |||||||||
| SwissProt | UniProtAcc | A5JYW9 | |||||||
| TREEFAM | TREEFAM_ID | TF106187 | |||||||
| UniProt_GCRP | UniProtAcc | A5JYW9 | |||||||
| OMIM | gene | 607776 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 21 Jun 2007 15:14:41 | WBPerson2970 | Name_change | CGC_name | sin-3 | ||||
| Other_name | pqn-28 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sin | ||||||||
| Allele (86) | |||||||||
| Strain | WBStrain00003037 | ||||||||
| WBStrain00023475 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Contained_in_operon | CEOP1980 | ||||||||
| Ortholog (40) | |||||||||
| Structured_description | Concise_description | sin-3 encodes an ortholog of the SIN3 family of histone deacetylase subunits, which also has a glutamine/asparagine-rich domain, possibly involved in epigenetic regulation; sin-3 has no obvious phenotype in mass RNAi screens; on the basis of its homology, SIN-3, when activated by promoter-specific transcription factors, is expected to work in conjunction with other histone deacetylase components to induce chromatin silencing; SIN-3 may also silence genes by colocating to them with the O-GlcNAc transferase homolog OGT-1. | Paper_evidence (13) | ||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 15 Jul 2009 00:00:00 | ||||||||
| Automated_description | Contributes to histone deacetylase activity. Involved in several processes, including cell fate specification; nematode male tail mating organ morphogenesis; and vulval development. Acts upstream of or within defense response to other organism and response to endoplasmic reticulum stress. Predicted to be located in nucleus. Predicted to be part of Sin3 complex. Expressed in CEP; inner labial neurons; ray structural cell; socket cell; and ventral nerve cord. Human ortholog(s) of this gene implicated in Huntington's disease and chromosome 15q24 deletion syndrome. Is an ortholog of human SIN3A (SIN3 transcription regulator family member A) and SIN3B (SIN3 transcription regulator family member B). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0060395 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19353) | ||||
| DOID:12858 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19353) | ||||||
| Molecular_info | Corresponding_CDS | F02E9.4a | |||||||
| F02E9.4b | |||||||||
| Corresponding_CDS_history | F02E9.4:wp93 | ||||||||
| Corresponding_transcript | F02E9.4a.1 | ||||||||
| F02E9.4b.1 | |||||||||
| Other_sequence (14) | |||||||||
| Associated_feature | WBsf656631 | ||||||||
| WBsf656632 | |||||||||
| WBsf976841 | |||||||||
| WBsf976842 | |||||||||
| WBsf976843 | |||||||||
| WBsf984425 | |||||||||
| WBsf1010230 | |||||||||
| WBsf218155 | |||||||||
| Experimental_info | RNAi_result (20) | ||||||||
| Expr_pattern | Chronogram1240 | ||||||||
| Expr4679 | |||||||||
| Expr5666 | |||||||||
| Expr1011048 | |||||||||
| Expr1031994 | |||||||||
| Expr1147804 | |||||||||
| Expr2015819 | |||||||||
| Expr2034052 | |||||||||
| Drives_construct | WBCnstr00003537 | ||||||||
| WBCnstr00012167 | |||||||||
| WBCnstr00035684 | |||||||||
| Construct_product | WBCnstr00035684 | ||||||||
| Regulate_expr_cluster | WBPaper00058598:sin-3(tm1276)_downregulated | ||||||||
| WBPaper00058598:sin-3(tm1276)_upregulated | |||||||||
| WBPaper00058691:sin-3(tm1276)_downregulated | |||||||||
| WBPaper00058691:sin-3(tm1276)_upregulated | |||||||||
| WBPaper00061203:sin-3(tm1276)_downregulated | |||||||||
| WBPaper00061203:sin-3(tm1276)_upregulated | |||||||||
| WBPaper00066085:sin-3(syb2172)_downregulated | |||||||||
| WBPaper00066085:sin-3(syb2172)_upregulated | |||||||||
| WBPaper00066085:sin-3(tm1276)_downregulated | |||||||||
| WBPaper00066085:sin-3(tm1276)_upregulated | |||||||||
| Antibody | WBAntibody00002881 | ||||||||
| WBAntibody00002882 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (138) | |||||||||
| Interaction (174) | |||||||||
| Map_info | Map | I | Position | 2.82673 | Error | 0.008126 | |||
| Positive | Positive_clone | F02E9 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4684 | |||||||
| Pseudo_map_position | |||||||||
| Reference (26) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
