WormBase Tree Display for Gene: WBGene00003421
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| WBGene00003421 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F09E8 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | msh-5 | Person_evidence | WBPerson1547 | |||||
| Sequence_name | F09E8.3 | ||||||||
| Molecular_name | F09E8.3a | ||||||||
| F09E8.3a.1 | |||||||||
| CE26678 | |||||||||
| F09E8.3b | |||||||||
| CE49987 | |||||||||
| F09E8.3b.1 | |||||||||
| Other_name | CELE_F09E8.3 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | msh-5 | ||||||||
| DB_info | Database | AceView | gene | 4N927 | |||||
| WormQTL | gene | WBGene00003421 | |||||||
| WormFlux | gene | WBGene00003421 | |||||||
| NDB | locus_tag | CELE_F09E8.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003421|UniProtKB=Q19272 | |||||||
| family | PTHR11361 | ||||||||
| NCBI | gene | 178268 | |||||||
| RefSeq | protein | NM_001380506.1 | |||||||
| NM_070130.8 | |||||||||
| SwissProt | UniProtAcc | Q19272 | |||||||
| UniProt_GCRP | UniProtAcc | Q19272 | |||||||
| OMIM | gene | 603382 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | msh | ||||||||
| Allele (169) | |||||||||
| Legacy_information | [Kelly KO, Villeneuve AM ] me23 homozygotes viable hermaphrodite, morphologically normal; 98% of eggs fail to hatch, Him: 42% of viable progeny are male. me45 similar. Cloned: F09E8.3, homologous to budding yeast MSH5. | ||||||||
| Strain | WBStrain00000279 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (20) | |||||||||
| Ortholog (36) | |||||||||
| Paralog | WBGene00001872 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00003418 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003422 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | msh-5 encodes a germline-specific homolog of the yeast and mammalian DNA mismatch repair protein MSH5 (MutS-family) that is required for crossing over and chiasma formation during Caenorhabditis elegans meiosis; inactivation of both rad-51 and msh-5 induces chromosome fragmentation, not seen with inactivation of either gene alone. | Paper_evidence | WBPaper00004377 | |||||
| WBPaper00004424 | |||||||||
| WBPaper00005134 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable double-stranded DNA binding activity. Involved in chiasma assembly. Located in nucleus. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; primary ovarian insufficiency 13; and spermatogenic failure. Is an ortholog of human MSH5 (mutS homolog 5). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0111910 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7328) | ||||
| DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7328) | ||||||
| DOID:0080870 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7328) | ||||||
| Molecular_info | Corresponding_CDS | F09E8.3a | |||||||
| F09E8.3b | |||||||||
| Corresponding_CDS_history | F09E8.3:wp37 | ||||||||
| Corresponding_transcript | F09E8.3a.1 | ||||||||
| F09E8.3b.1 | |||||||||
| Other_sequence | AF070070 | ||||||||
| TMC02651_1 | |||||||||
| JI167893.1 | |||||||||
| BXC01774_1 | |||||||||
| TM03704 | |||||||||
| Associated_feature | WBsf1018496 | ||||||||
| WBsf229395 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00030712 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00001814 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00012983 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00012984 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00008131 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00044136 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr10004 | ||||||||
| Expr1027885 | |||||||||
| Expr1031586 | |||||||||
| Expr1148104 | |||||||||
| Expr2013767 | |||||||||
| Expr2032002 | |||||||||
| Drives_construct | WBCnstr00036128 | ||||||||
| Construct_product | WBCnstr00036128 | ||||||||
| Antibody | WBAntibody00002196 | ||||||||
| WBAntibody00003031 | |||||||||
| Microarray_results (25) | |||||||||
| Expression_cluster (147) | |||||||||
| Interaction (73) | |||||||||
| Map_info | Map | IV | Position | 8.22608 | Error | 0.01548 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | F09E8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4008 | |||||||
| 4009 | |||||||||
| Reference (41) | |||||||||
| Remark | sequence connection from [Villeneuve AM] | ||||||||
| Sequence connection from [Boulton S, Vidal M] | |||||||||
| Data extracted from Kelly et al. (2000) | |||||||||
| F09E8.2 removed. email from JAH 0109 | |||||||||
| Positive_clone is based on mutant sequence [030403 ck1] | |||||||||
| Method | Gene |
