WormBase Tree Display for Gene: WBGene00004051
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| WBGene00004051 | SMap | S_parent | Sequence | F20C5 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | parg-1 | Person_evidence | WBPerson236 | |||||
| Sequence_name | F20C5.1 | ||||||||
| Molecular_name (27) | |||||||||
| Other_name | pme-3 | ||||||||
| CELE_F20C5.1 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | parg-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 18 Nov 2014 11:51:19 | WBPerson2970 | Name_change | CGC_name | parg-1 | ||||
| Other_name | pme-3 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | parg | ||||||||
| Allele (98) | |||||||||
| Possibly_affected_by | WBVar02157220 | ||||||||
| Strain | WBStrain00003311 | ||||||||
| WBStrain00035527 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (24) | |||||||||
| Ortholog (42) | |||||||||
| Paralog | WBGene00004052 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | parg-1 (formerly known as pme-3) encodes a poly(ADP-ribose) glycohydrolase (PARG) orthologous to human PARG (OMIM:603501) and paralogous to PARG-2; PARG-1 exhibits poly(ADP-ribose) glycohydrolase activity in vitro, and is required in vivo for normal resistance to ionizing radiation; PARG-1 is primarily expressed in the nuclei of nerve cells in the head and tail, as well as in the nerve cord and motor neurons; PARG-1 is also expressed in embryos; neuronal expression of PARG-1 may reflect a requirement for PARG in preventing neurodegeneration like that seen in Drosophila. | Paper_evidence | WBPaper00028953 | |||||
| WBPaper00029104 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 14 Nov 2014 00:00:00 | ||||||||
| Automated_description | Enables poly(ADP-ribose) glycohydrolase activity. Involved in nucleotide-sugar metabolic process and response to gamma radiation. Located in neuron projection and nucleus. Expressed in tail neurons and ventral cord neurons. Is an ortholog of human BPHL (biphenyl hydrolase like) and PARG (poly(ADP-ribose) glycohydrolase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F20C5.1a | |||||||
| F20C5.1b | |||||||||
| F20C5.1c | |||||||||
| F20C5.1d | |||||||||
| F20C5.1e | |||||||||
| F20C5.1f | |||||||||
| F20C5.1g | |||||||||
| F20C5.1h | |||||||||
| F20C5.1i | |||||||||
| Corresponding_CDS_history | F20C5.1:wp92 | ||||||||
| Corresponding_transcript | F20C5.1a.1 | ||||||||
| F20C5.1b.1 | |||||||||
| F20C5.1c.1 | |||||||||
| F20C5.1d.1 | |||||||||
| F20C5.1e.1 | |||||||||
| F20C5.1f.1 | |||||||||
| F20C5.1g.1 | |||||||||
| F20C5.1h.1 | |||||||||
| F20C5.1i.1 | |||||||||
| Other_sequence (12) | |||||||||
| Associated_feature | WBsf228736 | ||||||||
| WBsf228737 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00007757 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00013604 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00045086 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00065515 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00001869 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00065516 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00077896 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00003782 | ||||||||
| WBCnstr00004938 | |||||||||
| WBCnstr00037945 | |||||||||
| Construct_product | WBCnstr00037945 | ||||||||
| Regulate_expr_cluster | WBPaper00063924:PARG-1_interacting | ||||||||
| Antibody | WBAntibody00002939 | ||||||||
| Microarray_results (34) | |||||||||
| Expression_cluster (123) | |||||||||
| Interaction (13) | |||||||||
| Map_info | Map | IV | Position | 3.95897 | Error | 0.000944 | |||
| Positive | Positive_clone | F20C5 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4465 | |||||||
| 4592 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (14) | |||||||||
| Remark | Gene name created from parsing 'genotype' field from CGC strain information [krb 020721] | ||||||||
| Sequence connection from [Moerman DC], [krb 020722] | |||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
