WormBase Tree Display for Gene: WBGene00004052

WBGene00004052 SMap: S_parent: Sequence: H23L24
  Identity: Version: 2
    Name: CGC_name: parg-2 Person_evidence: WBPerson236
      Sequence_name: H23L24.5
      Molecular_name: H23L24.5
        H23L24.5.1
        CE32685
      Other_name: pme-4
        CELE_H23L24.5 Accession_evidence: NDB BX284604
      Public_name: parg-2
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:34 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 18 Nov 2014 11:51:19 WBPerson2970 Name_change: CGC_name: parg-2
                Other_name: pme-4
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: parg
    Allele (43)
    Strain: WBStrain00035943
      WBStrain00047360
      WBStrain00047361
    RNASeq_FPKM (74)
    GO_annotation (22)
    Ortholog (41)
    Paralog: WBGene00004051 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
    Structured_description: Concise_description: parg-2 (formerly known as pme-4) encodes a poly(ADP-ribose) glycohydrolase (PARG) orthologous to human PARG (OMIM:603501) and paralogous to PARG-1; PARG-2 exhibits poly(ADP-ribose) glycohydrolase activity in vitro, and is required in vivo for normal resistance to ionizing radiation; PARG-2 is primarily expressed in the cytoplasm of nerve cells in the head and tail, and also in embryos; neuronal expression of PARG-2 may reflect a requirement for PARG in preventing neurodegeneration like that seen in Drosophila. Paper_evidence: WBPaper00005600
            WBPaper00028953
            WBPaper00029104
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 14 Nov 2014 00:00:00
      Automated_description: Enables poly(ADP-ribose) glycohydrolase activity. Involved in nucleotide-sugar metabolic process and response to gamma radiation. Located in cytoplasm. Expressed in head neurons and tail neurons. Is an ortholog of human BPHL (biphenyl hydrolase like) and PARG (poly(ADP-ribose) glycohydrolase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: H23L24.5
    Corresponding_CDS_history: H23L24.5:wp90
    Corresponding_transcript: H23L24.5.1
    Associated_feature: WBsf668121
      WBsf230456
  Experimental_info: RNAi_result: WBRNAi00013332 Inferred_automatically: RNAi_primary
      WBRNAi00033743 Inferred_automatically: RNAi_primary
      WBRNAi00016298 Inferred_automatically: RNAi_primary
      WBRNAi00065517 Inferred_automatically: RNAi_primary
      WBRNAi00049464 Inferred_automatically: RNAi_primary
      WBRNAi00065516 Inferred_automatically: RNAi_primary
      WBRNAi00102083 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr4510
      Expr1016211
      Expr1153191
      Expr2014733
      Expr2032967
    Drives_construct: WBCnstr00004939
      WBCnstr00037944
    Construct_product: WBCnstr00037944
    Microarray_results (17)
    Expression_cluster (263)
    Interaction: WBInteraction000253282
      WBInteraction000580252
  Map_info: Map: IV Position: 3.95647 Error: 0.001836
    Positive: Positive_clone: H23L24 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4592
        4940
    Pseudo_map_position
  Reference (11)
  Remark: Sequence connection via email from [Desnoyers S], [krb 020729]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene