WormBase Tree Display for Gene: WBGene00001093
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| WBGene00001093 | SMap | S_parent | Sequence | T12E12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | drp-1 | Person_evidence | WBPerson733 | |||||
| Sequence_name | T12E12.4 | ||||||||
| Molecular_name | T12E12.4a | ||||||||
| T12E12.4a.1 | |||||||||
| CE30172 | |||||||||
| T12E12.4b | |||||||||
| CE30173 | |||||||||
| T12E12.4a.2 | |||||||||
| T12E12.4b.1 | |||||||||
| T12E12.4b.2 | |||||||||
| Other_name | CELE_T12E12.4 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | drp-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:23 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | drp | ||||||||
| Allele (45) | |||||||||
| Strain | WBStrain00005196 | ||||||||
| WBStrain00007389 | |||||||||
| WBStrain00007408 | |||||||||
| WBStrain00007414 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (30) | |||||||||
| Contained_in_operon | CEOP4168 | ||||||||
| Ortholog (39) | |||||||||
| Paralog | WBGene00001134 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00001130 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | drp-1 encodes a dynamin-related protein, orthologous to Dnm1p in S. cerevisiae and DRP1 in mammals, that is required for severing of the mitochondrial outer membrane during mitochondrial division. | Paper_evidence | WBPaper00003790 | |||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable GTP binding activity; GTPase activity; and microtubule binding activity. Involved in apoptotic mitochondrial changes; embryo development; and mitochondrial fission. Located in mitochondrion. Expressed in several structures, including germ line; non-striated muscle; preanal ganglion; rectal muscle; and somatic nervous system. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; encephalopathy due to defective mitochondrial and peroxisomal fission 1; optic atrophy 5; and pulmonary fibrosis. Is an ortholog of human DNM1L (dynamin 1 like). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00057005 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 20 Feb 2020 00:00:00 | ||||||||
| Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2973) | |||||
| DOID:0070347 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2973) | ||||||
| DOID:0111438 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2973) | ||||||
| DOID:3770 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2973) | ||||||
| Models_disease_asserted | WBDOannot00000741 | ||||||||
| Molecular_info | Corresponding_CDS | T12E12.4a | |||||||
| T12E12.4b | |||||||||
| Corresponding_transcript | T12E12.4a.1 | ||||||||
| T12E12.4a.2 | |||||||||
| T12E12.4b.1 | |||||||||
| T12E12.4b.2 | |||||||||
| Other_sequence (72) | |||||||||
| Associated_feature | WBsf655022 | ||||||||
| WBsf660150 | |||||||||
| WBsf981759 | |||||||||
| WBsf996535 | |||||||||
| WBsf228316 | |||||||||
| WBsf228317 | |||||||||
| WBsf228318 | |||||||||
| Experimental_info | RNAi_result (36) | ||||||||
| Expr_pattern | Expr543 | ||||||||
| Expr11473 | |||||||||
| Expr12437 | |||||||||
| Expr1017306 | |||||||||
| Expr1030697 | |||||||||
| Expr1156803 | |||||||||
| Expr2011094 | |||||||||
| Expr2029330 | |||||||||
| Drives_construct | WBCnstr00012431 | ||||||||
| WBCnstr00037085 | |||||||||
| Construct_product | WBCnstr00005418 | ||||||||
| WBCnstr00005420 | |||||||||
| WBCnstr00009299 | |||||||||
| WBCnstr00012431 | |||||||||
| WBCnstr00019040 | |||||||||
| WBCnstr00037085 | |||||||||
| Antibody | WBAntibody00001689 | ||||||||
| Microarray_results (33) | |||||||||
| Expression_cluster (152) | |||||||||
| Interaction (114) | |||||||||
| Map_info | Map | IV | Position | 1.82105 | Error | 0.005501 | |||
| Positive | Positive_clone | T12E12 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (93) | |||||||||
| Remark | Sequence connection from [Labrousse AM, van der Bliek AM] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
