WormBase Tree Display for Gene: WBGene00003784
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| WBGene00003784 | SMap | S_parent | Sequence | ZK1127 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | nos-2 | Person_evidence | WBPerson575 | |||||
| Sequence_name | ZK1127.1 | ||||||||
| Molecular_name | ZK1127.1 | ||||||||
| ZK1127.1.1 | |||||||||
| CE05121 | |||||||||
| Other_name | CELE_ZK1127.1 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | nos-2 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | nos | ||||||||
| Allele (22) | |||||||||
| Legacy_information | [Seydoux G] No mutants known. Encodes protein with similarity to Drosophila nanos. Predicted gene ZK1127.1 | ||||||||
| Strain | WBStrain00022251 | ||||||||
| WBStrain00003947 | |||||||||
| WBStrain00022439 | |||||||||
| WBStrain00022445 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Ortholog (19) | |||||||||
| Paralog | WBGene00003783 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00020167 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Inparanoid_8 | |||||||||
| Structured_description | Concise_description | nos-2 encodes one of three genes in C. elegans that contains a putative zinc-binding domain similar to the one found in Drosophila nanos; nos-2 affects incorporation of primordial germ cells into the somatic gonad, is required redundantly with nos-1 to prevent primordial germ cells from dividing in starved animals and to maintain germ cell viability during larval development in hermaphrodites and in males, and also functions together with nos-1 and nos-3 in the hermaphrodite switch from spermatogenesis to oogenesis; nos-2 is expressed in the primordial germ cells around the time of gastrulation from a maternal RNA associated with P granules, and it is expressed coordinately with nos-1in a dynamic fashion until the embryonic 200-cell stage. | Paper_evidence | WBPaper00003692 | |||||
| WBPaper00003762 | |||||||||
| WBPaper00004672 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| Date_last_updated | 11 Mar 2005 00:00:00 | ||||||||
| Automated_description | Predicted to enable mRNA binding activity and zinc ion binding activity. Involved in oogenesis and regulation of cell cycle. Located in cytoplasm. Expressed in P0; P4; Z2; and Z3. Human ortholog(s) of this gene implicated in spermatogenic failure 12. Is an ortholog of human NANOS1 (nanos C2HC-type zinc finger 1); NANOS2 (nanos C2HC-type zinc finger 2); and NANOS3 (nanos C2HC-type zinc finger 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0070171 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:23044) | ||||
| Molecular_info | Corresponding_CDS | ZK1127.1 | |||||||
| Corresponding_transcript | ZK1127.1.1 | ||||||||
| Other_sequence | CJC04685_1 | ||||||||
| CJC06275_1 | |||||||||
| CSC01626_1 | |||||||||
| CBC00647_1 | |||||||||
| FD515793.1 | |||||||||
| CR01356 | |||||||||
| CRC01394_1 | |||||||||
| Associated_feature (14) | |||||||||
| Experimental_info | RNAi_result (41) | ||||||||
| Expr_pattern | Expr1159 | ||||||||
| Expr1161 | |||||||||
| Expr1031770 | |||||||||
| Expr1162550 | |||||||||
| Expr2014357 | |||||||||
| Expr2032598 | |||||||||
| Drives_construct | WBCnstr00035869 | ||||||||
| Construct_product | WBCnstr00035869 | ||||||||
| Antibody | WBAntibody00000247 | ||||||||
| Microarray_results (29) | |||||||||
| Expression_cluster (190) | |||||||||
| Interaction (234) | |||||||||
| Map_info | Map | II | Position | 0.381622 | Error | 0.021659 | |||
| Positive | Positive_clone | ZK1127 | Author_evidence | Seydoux GC | |||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Mapping_data | Multi_point | 4542 | |||||||
| Pseudo_map_position | |||||||||
| Reference (64) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
