WormBase Tree Display for Gene: WBGene00003783
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| WBGene00003783 | SMap | S_parent | Sequence | R03D7 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | nos-1 | Person_evidence | WBPerson575 | |||||
| Sequence_name | R03D7.7 | ||||||||
| Molecular_name | R03D7.7 | ||||||||
| R03D7.7.1 | |||||||||
| CE01614 | |||||||||
| Other_name | CELE_R03D7.7 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | nos-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | nos | ||||||||
| Allele (39) | |||||||||
| Legacy_information | [Seydoux G] No mutants known. Encodes protein with similarity to Drosophila nanos. Predicted gene R03D7.7 | ||||||||
| Strain | WBStrain00022246 | ||||||||
| WBStrain00031345 | |||||||||
| WBStrain00003947 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (14) | |||||||||
| Ortholog (19) | |||||||||
| Paralog | WBGene00003784 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | nos-1 encodes an putative RNA-binding protein that contains a zinc-binding motif homologous to that of Drosophila Nanos, a posterior-group protein required for embryonic patterning and primordial germ cell development; in C. elegans, NOS-1 is required redundantly with NOS-2, a second Nanos homolog, for maintenance of germ cell viability during postembryonic development and for preventing primordial germ cells from dividing in the absence of food; nos-1 mRNA is expressed dynamically in the embryo, with early expression seen throughout the embryo and later expression restricted solely to germline blastomeres; nos-1 mRNA becomes undetectable after the 200-cell stage, but reappears later at the 550-cell stage; NOS-1 protein is not detectable in germline blastomeres until the 550-cell stage, suggesting that NOS-1 might actually function zygotically in germline specification. | Paper_evidence | WBPaper00003762 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable mRNA binding activity. Involved in medium-term memory and short-term memory. Predicted to be located in perinuclear region of cytoplasm. Expressed in Z2 and Z3. Human ortholog(s) of this gene implicated in spermatogenic failure 12. Is an ortholog of human NANOS1 (nanos C2HC-type zinc finger 1); NANOS2 (nanos C2HC-type zinc finger 2); and NANOS3 (nanos C2HC-type zinc finger 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0070171 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:23044) | ||||
| Molecular_info | Corresponding_CDS | R03D7.7 | |||||||
| Corresponding_transcript | R03D7.7.1 | ||||||||
| Other_sequence | ES564878.1 | ||||||||
| TSC10670_1 | |||||||||
| Associated_feature | WBsf976327 | ||||||||
| WBsf976328 | |||||||||
| WBsf976329 | |||||||||
| WBsf976330 | |||||||||
| WBsf989530 | |||||||||
| WBsf223865 | |||||||||
| Experimental_info | RNAi_result (14) | ||||||||
| Expr_pattern | Expr1158 | ||||||||
| Expr1160 | |||||||||
| Expr1012136 | |||||||||
| Expr1031769 | |||||||||
| Expr1154883 | |||||||||
| Expr2014356 | |||||||||
| Expr2032597 | |||||||||
| Drives_construct | WBCnstr00035870 | ||||||||
| Construct_product | WBCnstr00035870 | ||||||||
| Antibody | WBAntibody00000246 | ||||||||
| Microarray_results (17) | |||||||||
| Expression_cluster (129) | |||||||||
| Interaction (52) | |||||||||
| Map_info | Map | II | Position | 3.13419 | Error | 0.000394 | |||
| Positive | Positive_clone | R03D7 | Author_evidence | Seydoux GC | |||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Mapping_data | Multi_point | 4541 | |||||||
| 4695 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (34) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
