WormBase Tree Display for Gene: WBGene00004762
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| WBGene00004762 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F35G12 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | sel-5 | Person_evidence | WBPerson220 | |||||
| Sequence_name | F35G12.3 | ||||||||
| Molecular_name | F35G12.3a | ||||||||
| F35G12.3a.1 | |||||||||
| CE00971 | |||||||||
| F35G12.3b | |||||||||
| CE00972 | |||||||||
| F35G12.3b.1 | |||||||||
| Other_name | CELE_F35G12.3 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | sel-5 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sel | ||||||||
| Allele (103) | |||||||||
| Legacy_information | [C.elegansII] n1524 : suppressor of lin-12 hypermorphs (n302sd, etc.). Mosaic analysis indicates focus in VU not AC. [JT; MT] | ||||||||
| Strain | WBStrain00027023 | ||||||||
| WBStrain00031383 | |||||||||
| WBStrain00008036 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Ortholog (46) | |||||||||
| Paralog | WBGene00018516 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00008424 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | sel-5 encodes a serine/threonine kinase most similar to mammalian GAK1 and Saccharomyces cerevisiae Pak1p; SEL-5 is required for LIN-12/Notch-mediated signaling events that instruct cells of equivalent developmental potential to adopt distinct fates; sel-5 encodes two protein kinase isoforms generated from alternatively spliced mRNAs and appears to influence cell fate decisions by acting before or during ligand-dependent release of the LIN-12 intracellular domain. | Paper_evidence | WBPaper00003827 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable AP-2 adaptor complex binding activity and protein serine/threonine kinase activity. Predicted to be involved in positive regulation of Notch signaling pathway and regulation of clathrin-dependent endocytosis. Predicted to be located in cytoplasm. Used to study Parkinson's disease. Is an ortholog of human AAK1 (AP2 associated kinase 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00041253 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 18 Nov 2013 00:00:00 | ||||||||
| Disease_relevance | In elegans, alpha-synuclein (alpha-syn) toxicity, implicated in Parkinson''s disease and other synucleinopathies, is modeled by expressing it from the dopamine transporter (dat-1) gene promotor in transgenic GFP worms, resulting in an age-dependent progressive loss of dopaminergic neurons; using this system, it was seen that the knock-down of specific candidate genes in elegans, that interact with catp-6/ATP13A2, resulted in significant enhancement of alpha-syn-induced dopaminergic neurodegeneration; these catp-6/ATP13A2 interactors include the elegans ortholog of AP2 associated kinase 1 (AAK1; sel-5), neuropeptide Y receptor Y1 (npr-4), coagulation factor II (thrombin) receptor (dop-2 and npr-24), histone deacetylase 6 (hda-6), and YIP1 interacting factor homolog A (yif-1). | Homo sapiens | Paper_evidence | WBPaper00041253 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 19 Nov 2013 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000247 | ||||||||
| Molecular_info | Corresponding_CDS | F35G12.3a | |||||||
| F35G12.3b | |||||||||
| Corresponding_transcript | F35G12.3a.1 | ||||||||
| F35G12.3b.1 | |||||||||
| Other_sequence (20) | |||||||||
| Associated_feature | WBsf650985 | ||||||||
| WBsf666803 | |||||||||
| WBsf992177 | |||||||||
| WBsf226546 | |||||||||
| WBsf226547 | |||||||||
| WBsf226548 | |||||||||
| WBsf226549 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Expr1082 | ||||||||
| Expr5956 | |||||||||
| Expr1024245 | |||||||||
| Expr1032357 | |||||||||
| Expr1150268 | |||||||||
| Expr2015734 | |||||||||
| Expr2033967 | |||||||||
| Drives_construct | WBCnstr00002307 | ||||||||
| WBCnstr00035403 | |||||||||
| Construct_product | WBCnstr00010072 | ||||||||
| WBCnstr00035403 | |||||||||
| Microarray_results (34) | |||||||||
| Expression_cluster (107) | |||||||||
| Interaction (90) | |||||||||
| Map_info | Map | III | Position | -3.07351 | Error | 0.006086 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | sDf121 | |||||||
| Positive_clone | F35G12 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Mapping_data | Multi_point | 2305 | |||||||
| 2306 | |||||||||
| 2307 | |||||||||
| 2308 | |||||||||
| 3580 | |||||||||
| 3581 | |||||||||
| 4564 | |||||||||
| Pos_neg_data | 9165 | ||||||||
| Reference (15) | |||||||||
| Remark | [Iva Greenwald] published in Fares and Greenwald, Genetics 153, 1641-1654 (1999). See also cDNA Sequences AAF71545 (SEL-5A) and AAF71546 (SEL-5B). | ||||||||
| Method | Gene |
