| WBGene00004762 | Evidence | CGC_data_submission |
|---|
| SMap | S_parent | Sequence | F35G12 |
| Identity | Version | 1 |
| | Name | CGC_name | sel-5 | Person_evidence | WBPerson220 |
| | | Sequence_name | F35G12.3 |
| | | Molecular_name | F35G12.3a |
| | | | F35G12.3a.1 |
| | | | CE00971 |
| | | | F35G12.3b |
| | | | CE00972 |
| | | | F35G12.3b.1 |
| | | Other_name | CELE_F35G12.3 | Accession_evidence | NDB | BX284603 |
| | | Public_name | sel-5 |
| | DB_info | Database (13) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | sel |
| | Allele (103) |
| | Legacy_information | [C.elegansII] n1524 : suppressor of lin-12 hypermorphs (n302sd, etc.). Mosaic analysis indicates focus in VU not AC. [JT; MT] |
| | Strain | WBStrain00027023 |
| | | WBStrain00031383 |
| | | WBStrain00008036 |
| | RNASeq_FPKM (74) |
| | GO_annotation (19) |
| | Ortholog (46) |
| | Paralog | WBGene00018516 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00008424 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | Structured_description | Concise_description | sel-5 encodes a serine/threonine kinase most similar to mammalian GAK1 and Saccharomyces cerevisiae Pak1p; SEL-5 is required for LIN-12/Notch-mediated signaling events that instruct cells of equivalent developmental potential to adopt distinct fates; sel-5 encodes two protein kinase isoforms generated from alternatively spliced mRNAs and appears to influence cell fate decisions by acting before or during ligand-dependent release of the LIN-12 intracellular domain. | Paper_evidence | WBPaper00003827 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Predicted to enable AP-2 adaptor complex binding activity and protein serine/threonine kinase activity. Predicted to be involved in positive regulation of Notch signaling pathway and regulation of clathrin-dependent endocytosis. Predicted to be located in cytoplasm. Used to study Parkinson's disease. Is an ortholog of human AAK1 (AP2 associated kinase 1). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00041253 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 18 Nov 2013 00:00:00 |
| | Disease_relevance | In elegans, alpha-synuclein (alpha-syn) toxicity, implicated in Parkinson''s disease and other synucleinopathies, is modeled by expressing it from the dopamine transporter (dat-1) gene promotor in transgenic GFP worms, resulting in an age-dependent progressive loss of dopaminergic neurons; using this system, it was seen that the knock-down of specific candidate genes in elegans, that interact with catp-6/ATP13A2, resulted in significant enhancement of alpha-syn-induced dopaminergic neurodegeneration; these catp-6/ATP13A2 interactors include the elegans ortholog of AP2 associated kinase 1 (AAK1; sel-5), neuropeptide Y receptor Y1 (npr-4), coagulation factor II (thrombin) receptor (dop-2 and npr-24), histone deacetylase 6 (hda-6), and YIP1 interacting factor homolog A (yif-1). | Homo sapiens | Paper_evidence | WBPaper00041253 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 19 Nov 2013 00:00:00 |
| Models_disease_in_annotation | WBDOannot00000247 |
| Molecular_info | Corresponding_CDS | F35G12.3a |
| | | F35G12.3b |
| | Corresponding_transcript | F35G12.3a.1 |
| | | F35G12.3b.1 |
| | Other_sequence (20) |
| | Associated_feature | WBsf650985 |
| | | WBsf666803 |
| | | WBsf992177 |
| | | WBsf226546 |
| | | WBsf226547 |
| | | WBsf226548 |
| | | WBsf226549 |
| Experimental_info | RNAi_result (11) |
| | Expr_pattern | Expr1082 |
| | | Expr5956 |
| | | Expr1024245 |
| | | Expr1032357 |
| | | Expr1150268 |
| | | Expr2015734 |
| | | Expr2033967 |
| | Drives_construct | WBCnstr00002307 |
| | | WBCnstr00035403 |
| | Construct_product | WBCnstr00010072 |
| | | WBCnstr00035403 |
| | Microarray_results (34) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037946:LIN-39_interacting |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00040221:DAF-12_target_ALF9 |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044760:germline_specific |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049217:DAF-16_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050522:mafr-1(tm6082)_downregulated |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053302:alovudine_24h_regulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:PGCs_enriched_NuGen |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056443:sek-1(km4)_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058598:sin-3(tm1276)_upregulated |
| | | WBPaper00058691:sin-3(tm1276)_upregulated |
| | | WBPaper00059174:MEG-3_interacting |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059605:MUT-16_interacting |
| | | WBPaper00059664:srbc-48(ac23)_downregulated |
| | | WBPaper00060445:nfki-1(cer1)_upregulated_L4 |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060909:atfs-1(cmh15)_upregulated |
| | | WBPaper00061007:S.aquatilis_downregulated |
| | | WBPaper00061203:sin-3(tm1276)_downregulated |
| | | WBPaper00061203:spr-1(ok2144)_downregulated |
| | | WBPaper00061439:unc-30(ok613)_downregulated |
| | | WBPaper00061527:daf-18_2911-ced-2_4092 |
| | | WBPaper00061527:ima-1_20458-bath-41 |
| | | WBPaper00061527:kle-2_4298-vrk-1 |
| | | WBPaper00061527:npp-8_2951-rme-8_3001 |
| | | WBPaper00062193:hsf-1(RNAi)_downregulated |
| | | WBPaper00062520:qui-1(db104)_upregulated |
| | | WBPaper00063930:BRD-1_interacting |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065096:25C_vs_20C_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065373:Cisplatin_upregulated_WT |
| | | WBPaper00065373:sek-1(km4)_upregulated_Ref |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4489_group_4 |
| | | WBPaper00025032:cluster_73 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00030985:Serratia_marcesens_upregulated |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00037147:heatshock_upregulated |
| | | WBPaper00040210:Chlorpyrifos_24C_regulated |
| | | WBPaper00040823:alg-1(gk214)_downregulated |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040876:mir-35_upregulated |
| | | WBPaper00040963:TA200_down |
| | | WBPaper00040963:TA300_down |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041002:HF_11d_2.0mM_Up |
| | | WBPaper00041002:HQ_3d_2.0mM_Down |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00042178:hlh-29(tm284)_downregulated |
| | | WBPaper00042236:flcn-1(ok975)_upregulated |
| | | WBPaper00042258:DA1877_downregulated_GravidAdult |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00045263:nuo-6(qm200)_upregulated |
| | | WBPaper00048624:hlh-25(ok1710)_downregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00056330:mrps-5(RNAi)_downregulated |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | | [cgc6390]:Cluster_F |
| | | [cgc6390]:mixed_oogenesis-somatic |
| | Interaction (90) |
| Map_info | Map | III | Position | -3.07351 | Error | 0.006086 |
| | Well_ordered |
| | Positive | Inside_rearr | sDf121 |
| | | Positive_clone | F35G12 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 2305 |
| | | | 2306 |
| | | | 2307 |
| | | | 2308 |
| | | | 3580 |
| | | | 3581 |
| | | | 4564 |
| | | Pos_neg_data | 9165 |
| Reference (15) |
| Remark | [Iva Greenwald] published in Fares and Greenwald, Genetics 153, 1641-1654 (1999). See also cDNA Sequences AAF71545 (SEL-5A) and AAF71546 (SEL-5B). |
| Method | Gene |
