WormBase Tree Display for Gene: WBGene00000373

WBGene00000373 Evidence: Person_evidence: WBPerson427
    Author_evidence: Gilchrist EJ
  SMap: S_parent: Sequence: F08F3
  Identity: Version: 2
    Name: CGC_name: cyp-14A5
      Sequence_name: F08F3.7
      Molecular_name: F08F3.7
        F08F3.7.1
        CE09262
      Other_name: ccp-14A5 CGC_data_submission
        CELE_F08F3.7 Accession_evidence: NDB BX284605
      Public_name: cyp-14A5
    DB_info: Database: AceView gene 5F900
        WormQTL gene WBGene00000373
        WormFlux gene WBGene00000373
        NDB locus_tag CELE_F08F3.7
        Panther gene CAEEL|WormBase=WBGene00000373|UniProtKB=Q27531
          family PTHR24284
        NCBI gene 178926
        RefSeq protein NM_072034.6
        TrEMBL UniProtAcc Q27531
        UniProt_GCRP UniProtAcc Q27531
        OMIM gene 610670
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 21 Sep 2004 09:38:16 WBPerson1971 Name_change: CGC_name: ccp-14A5 -> cyp-14A5
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cyp
    Allele (39)
    Strain: WBStrain00035616
    RNASeq_FPKM (74)
    GO_annotation: 00080011
      00080012
      00080013
      00106062
      00107253
      00107254
      00107255
      00107256
    Ortholog (79)
    Paralog (42)
    Structured_description: Concise_description: cyp-14A5 encodes one of ~80 C. elegans cytochrome P450s: membrane-associated, heme-containing NADPH-dependent monooxygenases that catalyze the oxidative metabolism of a variety of exogenous compounds and endogenous substrates; cyp-14A5 expression is upregulated in response to stressors such as ionizing radiation and bacterial infection. Paper_evidence: WBPaper00028789
            WBPaper00032454
          Curator_confirmed: WBPerson48
            WBPerson1843
          Date_last_updated: 29 Aug 2011 00:00:00
      Automated_description: Predicted to enable heme binding activity; iron ion binding activity; and oxidoreductase activity. Involved in response to gamma radiation. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hepatitis; hematologic cancer (multiple); and hereditary spastic paraplegia 56. Is an ortholog of several human genes including CYP2D6 (cytochrome P450 family 2 subfamily D member 6); CYP2D7 (cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)); and CYP2W1 (cytochrome P450 family 2 subfamily W member 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (12)
  Molecular_info: Corresponding_CDS: F08F3.7
    Corresponding_transcript: F08F3.7.1
    Other_sequence: Oden_isotig10227
      Oden_isotig10228
      Oden_contig12097
      Oden_isotig10226
    Associated_feature: WBsf652626
      WBsf999998
      WBsf233677
  Experimental_info: RNAi_result: WBRNAi00030655 Inferred_automatically: RNAi_primary
      WBRNAi00012909 Inferred_automatically: RNAi_primary
      WBRNAi00044020 Inferred_automatically: RNAi_primary
      WBRNAi00007300 Inferred_automatically: RNAi_primary
      WBRNAi00092636 Inferred_automatically: RNAi_primary
      WBRNAi00116301 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1012010
      Expr1030200
      Expr1147988
      Expr2010694
      Expr2028933
    Drives_construct: WBCnstr00037589
    Construct_product: WBCnstr00037589
    Microarray_results (16)
    Expression_cluster (278)
    Interaction (12)
  Map_info: Map: V Position: -2.08686 Error: 0.028976
    Positive: Positive_clone: F08F3 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4182
        5414
    Pseudo_map_position
  Reference: WBPaper00031529
    WBPaper00032454
    WBPaper00034678
    WBPaper00035429
    WBPaper00037579
    WBPaper00038491
    WBPaper00055090
    WBPaper00056521
    WBPaper00061547
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene