WormBase Tree Display for Gene: WBGene00003576
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| WBGene00003576 | SMap | S_parent | Sequence | CHROMOSOME_IV | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | ndc-80 | Person_evidence | WBPerson283 | |||||
| Sequence_name | W01B6.9 | ||||||||
| Molecular_name | W01B6.9 | ||||||||
| W01B6.9.1 | |||||||||
| CE06537 | |||||||||
| Other_name | cogc-7 | Paper_evidence | WBPaper00026979 | ||||||
| Person_evidence | WBPerson449 | ||||||||
| CELE_W01B6.9 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | ndc-80 | ||||||||
| DB_info | Database | AceView | gene | 4K851 | |||||
| WormQTL | gene | WBGene00003576 | |||||||
| WormFlux | gene | WBGene00003576 | |||||||
| NDB | locus_tag | CELE_W01B6.9 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003576|UniProtKB=Q17635 | |||||||
| family | PTHR10643 | ||||||||
| NCBI | gene | 177873 | |||||||
| RefSeq | protein | NM_069429.5 | |||||||
| SwissProt | UniProtAcc | Q17635 | |||||||
| TREEFAM | TREEFAM_ID | TF101177 | |||||||
| UniProt_GCRP | UniProtAcc | Q17635 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:32 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 16 Jan 2006 17:11:27 | WBPerson2970 | Name_change | Other_name | cogc-7 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ndc | ||||||||
| Allele (30) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (38) | |||||||||
| Ortholog (30) | |||||||||
| Structured_description | Concise_description | ndc-80 (cogc-7) encodes an ortholog of mammalian COG-7 (OMIM:606978,mutated in congenital disorder of glycosylation), a subunit of lobe B ofthe conserved oligomeric Golgi complex (COGC); NDC-80 is also an outerkinetochore component orthologous to S. cerevisiae Ndc80p; NDC-80 affectsmetaphase plate formation in embryos (thus affecting chromosomesegregation), kinetochore-microtubule interactions, locomotion, vulvaldevelopment, body morphology, and embryonic viability; NDC-80 is weaklyrequired for normal gonadal distal tip cell migration, a process that alsorequires seven other orthologs of COGC subunits; like other lobe Bsubunits in both C. elegans and S. cerevisiae, NDC-80 is only partiallyrequired for normal function, while lobe A subunits are strongly requiredin either worms or yeast; NDC-80 interacts in vivo with KNL-1, HIM-10, anda homolog of Nuf2p, and NDC-80 and HIM-10 are codependent for kinetochoreassembly. | Paper_evidence | WBPaper00005330 | |||||
| WBPaper00005654 | |||||||||
| WBPaper00006142 | |||||||||
| WBPaper00006309 | |||||||||
| WBPaper00026979 | |||||||||
| WBPaper00028363 | |||||||||
| WBPaper00028599 | |||||||||
| WBPaper00028601 | |||||||||
| WBPaper00028602 | |||||||||
| WBPaper00028603 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 25 Oct 2006 00:00:00 | ||||||||
| Automated_description | Enables protein domain specific binding activity. Involved in several processes, including chromosome organization; gonad morphogenesis; and positive regulation of kinetochore assembly. Located in kinetochore. Part of Ndc80 complex. Human ortholog(s) of this gene implicated in colorectal cancer; lung non-small cell carcinoma; and stomach cancer. Is an ortholog of human NDC80 (NDC80 kinetochore complex component). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16909) | ||||
| DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16909) | ||||||
| DOID:10534 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16909) | ||||||
| Molecular_info | Corresponding_CDS | W01B6.9 | |||||||
| Corresponding_transcript | W01B6.9.1 | ||||||||
| Other_sequence | FG618964.1 | ||||||||
| CR01998 | |||||||||
| CBC04689_1 | |||||||||
| CR03902 | |||||||||
| CJC17913_1 | |||||||||
| CRC01587_1 | |||||||||
| CJC07860_1 | |||||||||
| Associated_feature | WBsf646280 | ||||||||
| WBsf660549 | |||||||||
| WBsf228926 | |||||||||
| WBsf228927 | |||||||||
| WBsf228928 | |||||||||
| Experimental_info | RNAi_result (17) | ||||||||
| Expr_pattern | Expr3437 | ||||||||
| Expr1017660 | |||||||||
| Expr1031629 | |||||||||
| Expr1158057 | |||||||||
| Expr2013927 | |||||||||
| Expr2032166 | |||||||||
| Drives_construct | WBCnstr00018541 | ||||||||
| WBCnstr00018542 | |||||||||
| WBCnstr00018543 | |||||||||
| WBCnstr00018544 | |||||||||
| WBCnstr00018545 | |||||||||
| WBCnstr00018553 | |||||||||
| WBCnstr00036029 | |||||||||
| Construct_product | WBCnstr00018541 | ||||||||
| WBCnstr00018542 | |||||||||
| WBCnstr00018543 | |||||||||
| WBCnstr00018544 | |||||||||
| WBCnstr00018545 | |||||||||
| WBCnstr00018553 | |||||||||
| WBCnstr00036029 | |||||||||
| Antibody | WBAntibody00000992 | ||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (160) | |||||||||
| Interaction (97) | |||||||||
| Map_info | Map | IV | Position | 4.49123 | Error | 0.003102 | |||
| Positive | Positive_clone | W01B6 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (25) | |||||||||
| Remark | Sequence connection from [Oegema K, Hyman AA] [090402 ck1] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
