WormBase Tree Display for Gene: WBGene00001227
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| WBGene00001227 | Evidence | Person_evidence | WBPerson599 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | R08D7 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | eif-3.D | |||||||
| Sequence_name | R08D7.3 | ||||||||
| Molecular_name | R08D7.3 | ||||||||
| R08D7.3.1 | |||||||||
| CE00291 | |||||||||
| Other_name | R08D7_3 | Paper_evidence | WBPaper00010001 | ||||||
| CELE_R08D7.3 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | eif-3.D | ||||||||
| DB_info | Database | AceView | gene | 3K60 | |||||
| WormQTL | gene | WBGene00001227 | |||||||
| WormFlux | gene | WBGene00001227 | |||||||
| NDB | locus_tag | CELE_R08D7.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00001227|UniProtKB=P30642 | |||||||
| family | PTHR12399 | ||||||||
| NCBI | gene | 176268 | |||||||
| RefSeq | protein | NM_066583.7 | |||||||
| SwissProt | UniProtAcc | P30642 | |||||||
| TREEFAM | TREEFAM_ID | TF101519 | |||||||
| UniProt_GCRP | UniProtAcc | P30642 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:23 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | eif | ||||||||
| Allele (21) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (26) | |||||||||
| Ortholog (40) | |||||||||
| Structured_description | Concise_description | eif-3.D encodes the C. elegans ortholog of the translation initiation factor 3 subunit d (eIF3d/Moe1); by homology, EIF-3.D is predicted to function as part of the eIF3 translation initiation complex but also as part of a Ras-mediated pathway that regulates mitotic spindle formation; in C. elegans, large-scale RNAi screens indicate that eif-3.D is required for embryonic and germline development, locomotion, and normal rates of post-embryonic growth; in the early embryo, eif-3.D is specifically required for the fidelity of meiotic divisions and normal pseudocleavage; eif-3.D function is likely conserved, as expression of eif-3.D in Schizosaccharomyces pombe can rescue the mitotic spindle and growth defects associated with moe1 mutant cells; to date, eif-3.D expression has been reported in anterior neurons and the pharynx, beginning at late stages of embryogenesis. | Paper_evidence | WBPaper00004403 | |||||
| WBPaper00005654 | |||||||||
| WBPaper00006395 | |||||||||
| WBPaper00012836 | |||||||||
| WBPaper00013635 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 20 Apr 2010 00:00:00 | ||||||||
| Automated_description | Predicted to enable translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 3 complex. Expressed in pharynx. Is an ortholog of human EIF3D (eukaryotic translation initiation factor 3 subunit D). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | R08D7.3 | |||||||
| Corresponding_transcript | R08D7.3.1 | ||||||||
| Other_sequence (132) | |||||||||
| Associated_feature | WBsf651324 | ||||||||
| WBsf667209 | |||||||||
| WBsf227215 | |||||||||
| Experimental_info | RNAi_result (15) | ||||||||
| Expr_pattern | Expr22 | ||||||||
| Expr1023974 | |||||||||
| Expr1030775 | |||||||||
| Expr1155221 | |||||||||
| Expr2011254 | |||||||||
| Expr2029490 | |||||||||
| Drives_construct | WBCnstr00037025 | ||||||||
| Construct_product | WBCnstr00037025 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (121) | |||||||||
| Interaction (286) | |||||||||
| Map_info | Map | III | Position | 0.05462 | Error | 0.000942 | |||
| Positive | Positive_clone | R08D7 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00010001 | ||||||||
| WBPaper00027281 | |||||||||
| WBPaper00031224 | |||||||||
| WBPaper00032961 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00041771 | |||||||||
| WBPaper00049828 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00061547 | |||||||||
| Remark | The capital letters are used here to distinguish the different eIF3 subunit genes. This roughly agrees with worm gene nomenclature and it makes clear the orthologies for these universal factors (eif-3B corresponding to eIF3b, and so on), in the unified eIF3 nomenclature proposed by Browning KS et al (2001)[JAH][030106 ck1] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
