WormBase Tree Display for Gene: WBGene00006997
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| WBGene00006997 | Evidence | Paper_evidence | WBPaper00006310 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | Y38A8 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | zyg-12 | Person_evidence | WBPerson698 | |||||
| Sequence_name | ZK546.1 | ||||||||
| Molecular_name (16) | |||||||||
| Other_name | ber-1 | ||||||||
| CELE_ZK546.1 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | zyg-12 | ||||||||
| DB_info | Database | AceView | gene | 2F243 | |||||
| WormQTL | gene | WBGene00006997 | |||||||
| OMIM | disease | 610743 | |||||||
| 612998 | |||||||||
| NDB | locus_tag | CELE_ZK546.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006997|UniProtKB=Q23529 | |||||||
| family | PTHR18947 | ||||||||
| NCBI | gene | 24105291 | |||||||
| RefSeq | protein | NM_001373710.2 | |||||||
| NM_001306592.3 | |||||||||
| NM_001306591.3 | |||||||||
| NM_001306590.3 | |||||||||
| SwissProt | UniProtAcc | Q23529 | |||||||
| TREEFAM | TREEFAM_ID | TF320231 | |||||||
| UniProt_GCRP | UniProtAcc | Q23529 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:44 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info (12) | |||||||||
| Disease_info | Experimental_model | DOID:11726 | Homo sapiens | Paper_evidence | WBPaper00040268 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 30 Apr 2013 00:00:00 | ||||||||
| Disease_relevance | Studies in elegans have contributed much to the knowledge of SUN-KASH protein complexes which link components of the nucleus to the cytoplasm; KASH domain proteins in elegans which include zyg-12, anc-1, unc-83 and Y67H2A.5 are involved in nuclear positioning and migration; the family of mammalian KASH (klarsicht, ANC-1 and Syne) domain proteins include Nesprin-1/SYNE1, Nesprin-2/SYNE2, Nesprin-3/SYNE3 and Nesprin-4/SYNE4) that encode at least 12 isoforms, by alternative transcription and splicing; most KASH domain proteins do not share primary sequence homology outside of their KASH domain; mutations in SYNE1, similar to those in LMNA/Lamin, cause laminopathic diseases like Emery-Dreifuss muscular dystrophy (EDMD) and Spinocerebellar ataxia. | Homo sapiens | Paper_evidence | WBPaper00040268 | |||||
| Accession_evidence | OMIM | 612998 | |||||||
| 610743 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 19 Mar 2012 00:00:00 | ||||||||
| Modifies_disease | DOID:070355 | ||||||||
| Models_disease_in_annotation | WBDOannot00000052 | ||||||||
| Modifies_disease_in_annotation | WBDOannot00001301 | ||||||||
| Molecular_info | Corresponding_CDS | ZK546.1a | |||||||
| ZK546.1b | |||||||||
| ZK546.1c | |||||||||
| ZK546.1d | |||||||||
| Corresponding_CDS_history | ZK546.1:wp86 | ||||||||
| Corresponding_transcript | ZK546.1a.1 | ||||||||
| ZK546.1a.2 | |||||||||
| ZK546.1a.3 | |||||||||
| ZK546.1b.1 | |||||||||
| ZK546.1c.1 | |||||||||
| ZK546.1d.1 | |||||||||
| ZK546.1d.2 | |||||||||
| ZK546.1d.3 | |||||||||
| Other_sequence | CBC06237_1 | ||||||||
| Associated_feature | WBsf987749 | ||||||||
| WBsf987750 | |||||||||
| WBsf987751 | |||||||||
| WBsf221207 | |||||||||
| WBsf221208 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00009474 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00038328 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00059501 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027075 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr2828 | ||||||||
| Expr2829 | |||||||||
| Expr12819 | |||||||||
| Expr1012697 | |||||||||
| Expr1032993 | |||||||||
| Expr1162915 | |||||||||
| Expr2018210 | |||||||||
| Expr2036348 | |||||||||
| Drives_construct | WBCnstr00001382 | ||||||||
| WBCnstr00010976 | |||||||||
| Construct_product | WBCnstr00010976 | ||||||||
| WBCnstr00016080 | |||||||||
| WBCnstr00016084 | |||||||||
| Antibody | WBAntibody00000705 | ||||||||
| Microarray_results (36) | |||||||||
| Expression_cluster (100) | |||||||||
| Interaction (49) | |||||||||
| Map_info | Map | II | Position | -2.65 | |||||
| Positive | Positive_clone | ZK546 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 540 | |||||||
| Multi_point | 477 | ||||||||
| Reference (54) | |||||||||
| Remark | [200811 gw3] Modified Map position as it was a reverse physical that could not be fixed by automated methods. (-2.63542) | ||||||||
| Method | Gene |
