WormBase Tree Display for Gene: WBGene00016990

WBGene00016990 SMap: S_parent: Sequence: CD4
  Identity: Version: 2
    Name: CGC_name: vps-37 Person_evidence: WBPerson3188
      Sequence_name: CD4.4
      Molecular_name: CD4.4
        CD4.4.1
        CE16952
      Other_name: CELE_CD4.4 Accession_evidence: NDB BX284605
      Public_name: vps-37
    DB_info: Database: AceView gene 5G71
        WormQTL gene WBGene00016990
        WormFlux gene WBGene00016990
        NDB locus_tag CELE_CD4.4
        Panther gene CAEEL|WormBase=WBGene00016990|UniProtKB=O44158
          family PTHR13678
        NCBI gene 178944
        RefSeq protein NM_072073.5
        TREEFAM TREEFAM_ID TF321840
        TrEMBL UniProtAcc O44158
        UniProt_GCRP UniProtAcc O44158
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:58 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 10 Sep 2007 09:52:01 WBPerson2970 Name_change: CGC_name: vps-37
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: vps
    Allele (15)
    Strain: WBStrain00002948
      WBStrain00036336
    RNASeq_FPKM (74)
    GO_annotation (14)
    Contained_in_operon: CEOP5076
    Ortholog (44)
    Structured_description: Concise_description: vps-37 encodes the C. elegans ortholog of Saccharomyces cerevisiae Srn2p/Vps37p, a member of the endosomal sorting ESCRT-I complex that functions in endosomal sorting of mono-ubiquitinated membrane proteins; in C. elegans, VPS-37 is an essential component of the ESCRT-I complex (other members include VPS-28, MVB-12, and TSG-101) that affects the rate at which cell surface receptors are degraded and hence, the rate at which their activity is downregulated; a VPS-37::GFP fusion protein localizes to the cytosol and to endosomal membranes. Paper_evidence: WBPaper00031035
          Curator_confirmed: WBPerson1843
          Date_last_updated: 09 Jul 2010 00:00:00
      Automated_description: Involved in receptor catabolic process. Located in cytosol and endosome membrane. Part of ESCRT I complex. Expressed in head and tail. Is an ortholog of human VPS37B (VPS37B subunit of ESCRT-I). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: CD4.4
    Corresponding_transcript: CD4.4.1
    Other_sequence (14)
    Associated_feature: WBsf646815
      WBsf231771
  Experimental_info: RNAi_result (60)
    Expr_pattern: Expr5605
      Expr1018249
      Expr1037296
      Expr1147284
      Expr2018028
      Expr2036165
    Drives_construct: WBCnstr00003454
      WBCnstr00027652
    Construct_product: WBCnstr00000920
      WBCnstr00027652
    Microarray_results (20)
    Expression_cluster (105)
    Interaction (36)
  Map_info: Map: V Position: -1.37551 Error: 0.00596
    Positive: Positive_clone: CD4 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00027740
    WBPaper00031035
    WBPaper00031212
    WBPaper00031867
    WBPaper00038491
    WBPaper00038585
    WBPaper00039823
    WBPaper00055090
    WBPaper00064078
    WBPaper00064325
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene