WormBase Tree Display for Gene: WBGene00002992
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| WBGene00002992 | SMap | S_parent | Sequence | CHROMOSOME_IV | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | lin-3 | Person_evidence | WBPerson261 | |||||
| Sequence_name | F36H1.4 | ||||||||
| Molecular_name (27) | |||||||||
| Other_name | let-94 | ||||||||
| sli-4 | Paper_evidence | WBPaper00028495 | |||||||
| Person_evidence | WBPerson625 | ||||||||
| CELE_F36H1.4 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | lin-3 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 05 Oct 2006 10:39:45 | WBPerson2970 | Name_change | Other_name | sli-4 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lin | ||||||||
| Reference_allele | WBVar00143992 | ||||||||
| Allele (126) | |||||||||
| Legacy_information | e1417 : adult hermaphrodite vulvaless (penetrance 89%); HME2; adult male wildtype ME2. NA4 (n378 (resembles e1417); n1059 (early larval lethal); n1058 (early larval lethal/sterile adult ME3)). | ||||||||
| See also e1417, n378, n1058, n1059, s751, s1263, s1750 | |||||||||
| [C.elegansII] e1417 : adult hermaphrodite vulvaless (penetrance 89%); HME2; adult male wildtype ME2. OA>10: n378 (resembles e1417)d,; n1059 (early larval lethal), n1058 (early larval lethal/sterile adult),s751 (pka let-94, late larval lethal, s751/Df early larval lethal), s1750 (homozygote and hemizygote mid larval lethal), etc. Cloned: encodes proteins with similarity to EGF family. Transgene overexpression leads to Muv(extra vulval differentiation). [Hill and Sternberg 1992; BC; MT; PS] | |||||||||
| Strain (13) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (32) | |||||||||
| Ortholog (21) | |||||||||
| Structured_description | Concise_description | lin-3 encodes a member of the EGF family of peptide growth factors that affects induction of vulval development, viability, ovulation, behavioral quiescence after stress, and male spicule development; it acts genetically upstream of its presumptive receptor let-23, and is expressed in multiple locations consistent with it acting as a localized ligand; for example, the anchor cell of the developing gonad, which induces vulval development. | Paper_evidence | WBPaper00000496 | |||||
| WBPaper00001573 | |||||||||
| WBPaper00045813 | |||||||||
| WBPaper00002043 | |||||||||
| Person_evidence | WBPerson625 | ||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 13 Jul 2015 00:00:00 | ||||||||
| Automated_description | Enables receptor ligand activity. Involved in several processes, including positive regulation of ovulation; positive regulation of vulval development; and reproductive process. Located in plasma membrane. Expressed in several structures, including excretory canal; germ line; hermaphrodite gonad; rectal epithelial cell; and vulF. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F36H1.4a | |||||||
| F36H1.4b | |||||||||
| F36H1.4c | |||||||||
| F36H1.4d | |||||||||
| F36H1.4e | |||||||||
| F36H1.4f | |||||||||
| F36H1.4g | |||||||||
| F36H1.4h | |||||||||
| Corresponding_CDS_history | F36H1.4:wp52 | ||||||||
| Corresponding_transcript (11) | |||||||||
| Other_sequence | CR09820 | ||||||||
| CRC07071_1 | |||||||||
| CJC02266_1 | |||||||||
| Associated_feature (12) | |||||||||
| Experimental_info | RNAi_result (54) | ||||||||
| Expr_pattern (16) | |||||||||
| Drives_construct (19) | |||||||||
| Construct_product (27) | |||||||||
| Microarray_results (44) | |||||||||
| Expression_cluster (158) | |||||||||
| Interaction (299) | |||||||||
| WBProcess | WBbiopr:00000020 | ||||||||
| WBbiopr:00000044 | |||||||||
| WBbiopr:00000067 | |||||||||
| WBbiopr:00000070 | |||||||||
| WBbiopr:00000071 | |||||||||
| Map_info | Map | IV | Position | 4.82027 | Error | 0.004649 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | F36H1 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| PS#001 | |||||||||
| Mapping_data | 2_point | 3296 | |||||||
| Multi_point | 117 | ||||||||
| 382 | |||||||||
| 383 | |||||||||
| 603 | |||||||||
| 678 | |||||||||
| 774 | |||||||||
| 1135 | |||||||||
| 1137 | |||||||||
| 1276 | |||||||||
| 1640 | |||||||||
| Pos_neg_data (16) | |||||||||
| Reference (361) | |||||||||
| Remark | Updated sequence connections to take account of splice variants. [02/03/28 krb] | ||||||||
| Method | Gene |
