WormBase Tree Display for Gene: WBGene00002992

WBGene00002992 SMap: S_parent: Sequence: CHROMOSOME_IV
  Identity: Version: 2
    Name: CGC_name: lin-3 Person_evidence: WBPerson261
      Sequence_name: F36H1.4
      Molecular_name (27)
      Other_name: let-94
        sli-4 Paper_evidence: WBPaper00028495
          Person_evidence: WBPerson625
        CELE_F36H1.4 Accession_evidence: NDB BX284604
      Public_name: lin-3
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:30 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 05 Oct 2006 10:39:45 WBPerson2970 Name_change: Other_name: sli-4
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: lin
    Reference_allele: WBVar00143992
    Allele: WBVar00089467
      WBVar00241881
      WBVar00248903
      WBVar00242206
      WBVar00603911
      WBVar01500079
      WBVar00603912
      WBVar00089929
      WBVar00089930
      WBVar02134649
      WBVar02134650
      WBVar02134651
      WBVar02134652
      WBVar01498996
      WBVar00941121
      WBVar01499925
      WBVar01857719
      WBVar00941122
      WBVar01857720
      WBVar00941123
      WBVar01857721
      WBVar00941124
      WBVar00941125
      WBVar01857722
      WBVar00941126
      WBVar01857723
      WBVar00941127
      WBVar01857724
      WBVar00941128
      WBVar01630899
      WBVar01857725
      WBVar00941129
      WBVar00941130
      WBVar00941131
      WBVar00941132
      WBVar00941133
      WBVar00941134
      WBVar00941135
      WBVar00941136
      WBVar00089466
      WBVar00941137
      WBVar00941138
      WBVar00941139
      WBVar00191925
      WBVar00941140
      WBVar00941141
      WBVar00059270
      WBVar00941142
      WBVar00941143
      WBVar00941144
      WBVar00941145
      WBVar00941146
      WBVar00941147
      WBVar00941148
      WBVar00941149
      WBVar00941150
      WBVar00941151
      WBVar00941152
      WBVar00941153
      WBVar00941154
      WBVar00941155
      WBVar00941156
      WBVar01410559
      WBVar00941157
      WBVar00941158
      WBVar00941159
      WBVar00941160
      WBVar00941161
      WBVar00941162
      WBVar00941163
      WBVar00941164
      WBVar01795471
      WBVar01795472
      WBVar00941165
      WBVar01795473
      WBVar00941166
      WBVar00941167
      WBVar01795474
      WBVar00941168
      WBVar00941169
      WBVar00941170
      WBVar00236607
      WBVar00941171
      WBVar00941172
      WBVar00941173
      WBVar00941174
      WBVar00941175
      WBVar00941176
      WBVar00941177
      WBVar02123093
      WBVar01499250
      WBVar02037149
      WBVar02041964
      WBVar01828134
      WBVar02124207
      WBVar01454124
      WBVar00435225
      WBVar00435226
      WBVar00435227
      WBVar00143992
      WBVar00435228
      WBVar00435229
      WBVar00435230
      WBVar00435231
      WBVar00435232
      WBVar00435233
      WBVar00435234
      WBVar00435235
      WBVar00435236
      WBVar00435237
      WBVar00435238
      WBVar01482357
      WBVar02058897
      WBVar02058898
      WBVar02058899
      WBVar02058900
      WBVar00248898
      WBVar00248899
      WBVar00248900
      WBVar00241992
      WBVar02147215
      WBVar02147216
      WBVar02147217
      WBVar02147218
      WBVar01500245
      WBVar02147219
    Legacy_information: e1417 : adult hermaphrodite vulvaless (penetrance 89%); HME2; adult male wildtype ME2. NA4 (n378 (resembles e1417); n1059 (early larval lethal); n1058 (early larval lethal/sterile adult ME3)).
      See also e1417, n378, n1058, n1059, s751, s1263, s1750
      [C.elegansII] e1417 : adult hermaphrodite vulvaless (penetrance 89%); HME2; adult male wildtype ME2. OA>10: n378 (resembles e1417)d,; n1059 (early larval lethal), n1058 (early larval lethal/sterile adult),s751 (pka let-94, late larval lethal, s751/Df early larval lethal), s1750 (homozygote and hemizygote mid larval lethal), etc. Cloned: encodes proteins with similarity to EGF family. Transgene overexpression leads to Muv(extra vulval differentiation). [Hill and Sternberg 1992; BC; MT; PS]
    Strain (13)
    RNASeq_FPKM (74)
    GO_annotation (32)
    Ortholog (21)
    Structured_description: Concise_description: lin-3 encodes a member of the EGF family of peptide growth factors that affects induction of vulval development, viability, ovulation, behavioral quiescence after stress, and male spicule development; it acts genetically upstream of its presumptive receptor let-23, and is expressed in multiple locations consistent with it acting as a localized ligand; for example, the anchor cell of the developing gonad, which induces vulval development. Paper_evidence: WBPaper00000496
            WBPaper00001573
            WBPaper00045813
            WBPaper00002043
          Person_evidence: WBPerson625
          Curator_confirmed: WBPerson324
            WBPerson567
          Date_last_updated: 13 Jul 2015 00:00:00
      Automated_description: Enables receptor ligand activity. Involved in several processes, including positive regulation of ovulation; positive regulation of vulval development; and reproductive process. Located in plasma membrane. Expressed in several structures, including excretory canal; germ line; hermaphrodite gonad; rectal epithelial cell; and vulF. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F36H1.4a
      F36H1.4b
      F36H1.4c
      F36H1.4d
      F36H1.4e
      F36H1.4f
      F36H1.4g
      F36H1.4h
    Corresponding_CDS_history: F36H1.4:wp52
    Corresponding_transcript (11)
    Other_sequence: CR09820
      CRC07071_1
      CJC02266_1
    Associated_feature (12)
  Experimental_info: RNAi_result (54)
    Expr_pattern (16)
    Drives_construct (19)
    Construct_product (27)
    Microarray_results (44)
    Expression_cluster (158)
    Interaction (299)
    WBProcess: WBbiopr:00000020
      WBbiopr:00000044
      WBbiopr:00000067
      WBbiopr:00000070
      WBbiopr:00000071
  Map_info: Map: IV Position: 4.82027 Error: 0.004649
    Well_ordered
    Positive: Positive_clone: F36H1 Inferred_automatically: From sequence, transcript, pseudogene data
        PS#001
    Mapping_data: 2_point: 3296
      Multi_point: 117
        382
        383
        603
        678
        774
        1135
        1137
        1276
        1640
      Pos_neg_data (16)
  Reference (361)
  Remark: Updated sequence connections to take account of splice variants. [02/03/28 krb]
  Method: Gene