WormBase Tree Display for Gene: WBGene00002028
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| WBGene00002028 | SMap | S_parent | Sequence | F08B4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | hst-1 | Person_evidence | WBPerson1831 | |||||
| Sequence_name | F08B4.6 | ||||||||
| Molecular_name | F08B4.6 | ||||||||
| F08B4.6.1 | |||||||||
| CE46914 | |||||||||
| Other_name | CELE_F08B4.6 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | hst-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | hst | ||||||||
| Allele (43) | |||||||||
| Strain | WBStrain00036041 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (18) | |||||||||
| Ortholog (53) | |||||||||
| Paralog | WBGene00002030 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00044303 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | hst-1 encodes the C. elegans ortholog of N-deacetylase/N-sulfotransferase (NDST), a bifunctional enzyme that catalyzes N-deacetylation and N-sulfation of N-acetylglucosamine residues in heparan sulfate; loss of hst-1 activity has been reported to result in embryonic lethality at various stages of development, defects in ventral neuroblast migrations during epidermal enclosure, and cessation of egg production in injected hermaphrodites. | Paper_evidence | WBPaper00004540 | |||||
| WBPaper00027618 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 09 Apr 2008 00:00:00 | ||||||||
| Automated_description | Predicted to enable [heparan sulfate]-glucosamine N-sulfotransferase activity and deacetylase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process. Predicted to be located in Golgi apparatus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 46. Is an ortholog of several human genes including NDST1 (N-deacetylase and N-sulfotransferase 1); NDST2 (N-deacetylase and N-sulfotransferase 2); and NDST3 (N-deacetylase and N-sulfotransferase 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0081210 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7680) | ||||
| Molecular_info | Corresponding_CDS | F08B4.6 | |||||||
| Corresponding_CDS_history | F08B4.6:wp92 | ||||||||
| F08B4.6:wp229 | |||||||||
| Corresponding_transcript | F08B4.6.1 | ||||||||
| Other_sequence (40) | |||||||||
| Associated_feature | WBsf652010 | ||||||||
| WBsf230453 | |||||||||
| WBsf230454 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00012868 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00043971 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00062194 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00085699 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00030634 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1010220 | ||||||||
| Expr1031183 | |||||||||
| Expr1147945 | |||||||||
| Expr2012633 | |||||||||
| Expr2030869 | |||||||||
| Drives_construct | WBCnstr00036511 | ||||||||
| Construct_product | WBCnstr00036511 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (113) | |||||||||
| Interaction (16) | |||||||||
| Map_info | Map | IV | Position | 3.93215 | Error | 0.002647 | |||
| Positive | Positive_clone | F08B4 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4874 | |||||||
| 4940 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (12) | |||||||||
| Remark | Sequence connection from [Turnbull J, Kinnunen T]. krb 13/11/01 | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
