WormBase Tree Display for Gene: WBGene00002028

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WBGene00002028	SMap	S_parent	Sequence	F08B4
	Identity	Version	1
		Name	CGC_name	hst-1	Person_evidence	WBPerson1831
			Sequence_name	F08B4.6
			Molecular_name	F08B4.6
				F08B4.6.1
				CE46914
			Other_name	CELE_F08B4.6	Accession_evidence	NDB	BX284604
			Public_name	hst-1
		DB_info	Database (13)
		Species	Caenorhabditis elegans
		History	Version_change	1	07 Apr 2004 11:29:26	WBPerson1971	Event	Imported	Initial conversion from geneace
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	hst
		Allele (43)
		Strain	WBStrain00036041
		RNASeq_FPKM (74)
		GO_annotation (18)
		Ortholog (53)
		Paralog	WBGene00002030	Caenorhabditis elegans	From_analysis	Panther
						WormBase-Compara
			WBGene00044303	Caenorhabditis elegans	From_analysis	Panther
						WormBase-Compara
		Structured_description	Concise_description	hst-1 encodes the C. elegans ortholog of N-deacetylase/N-sulfotransferase (NDST), a bifunctional enzyme that catalyzes N-deacetylation and N-sulfation of N-acetylglucosamine residues in heparan sulfate; loss of hst-1 activity has been reported to result in embryonic lethality at various stages of development, defects in ventral neuroblast migrations during epidermal enclosure, and cessation of egg production in injected hermaphrodites.	Paper_evidence	WBPaper00004540
						WBPaper00027618
					Curator_confirmed	WBPerson1843
					Date_last_updated	09 Apr 2008 00:00:00
			Automated_description	Predicted to enable [heparan sulfate]-glucosamine N-sulfotransferase activity and deacetylase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process. Predicted to be located in Golgi apparatus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 46. Is an ortholog of several human genes including NDST1 (N-deacetylase and N-sulfotransferase 1); NDST2 (N-deacetylase and N-sulfotransferase 2); and NDST3 (N-deacetylase and N-sulfotransferase 3).	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Disease_info	Potential_model	DOID:0081210	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:7680)
	Molecular_info	Corresponding_CDS	F08B4.6
		Corresponding_CDS_history	F08B4.6:wp92
			F08B4.6:wp229
		Corresponding_transcript	F08B4.6.1
		Other_sequence (40)
		Associated_feature	WBsf652010
			WBsf230453
			WBsf230454
	Experimental_info	RNAi_result	WBRNAi00012868	Inferred_automatically	RNAi_primary
			WBRNAi00043971	Inferred_automatically	RNAi_primary
			WBRNAi00062194	Inferred_automatically	RNAi_primary
			WBRNAi00085699	Inferred_automatically	RNAi_primary
			WBRNAi00030634	Inferred_automatically	RNAi_primary
		Expr_pattern	Expr1010220
			Expr1031183
			Expr1147945
			Expr2012633
			Expr2030869
		Drives_construct	WBCnstr00036511
		Construct_product	WBCnstr00036511
		Microarray_results (20)
		Expression_cluster	WBPaper00031040:TGF-beta_adult_downregulated
			WBPaper00033065:isp-1-1(qm150)_upregulated
			WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
			WBPaper00037950:AVE-neuron_L1-larva_expressed
			WBPaper00037950:BAG-neuron_blastula-embryo_expressed
			WBPaper00037950:bodywall-muscle_L1-larva_expressed
			WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
			WBPaper00037950:coelomocytes_L1-larva_expressed
			WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
			WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
			WBPaper00037950:hypodermis_L1-larva_expressed
			WBPaper00044426:rotenone_24h_downregulated
			WBPaper00044656:tatn-1(qd182)_downregulated
			WBPaper00044736:flat_dev_expression
			WBPaper00044760:germline_specific
			WBPaper00045521:Oogenic
			WBPaper00045729:gld-2(RNAi)_downregulated
			WBPaper00048988:neuron_expressed
			WBPaper00049498:npr-1(ur89)_regulated_6
			WBPaper00049545:jmjd-3.1(+)_upregulated
			WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
			WBPaper00049942:hsf-1(RNAi)_upregulated
			WBPaper00050234:lin-28(RNAi)_upregulated
			WBPaper00050344:AFD-neuron_enriched
			WBPaper00050344:PLM-neuron_enriched
			WBPaper00050488:adult_vs_dauer_regulated_N2_20C
			WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
			WBPaper00050990:intestine_expressed
			WBPaper00051039:germline_enriched
			WBPaper00051265:F4_morc-1(tm6048)_upregulated
			WBPaper00052884:emb-4(hc60)_downregulated
			WBPaper00053184:sma-2(rax5)_downregulated
			WBPaper00053184:sma-4(rax3)_downregulated
			WBPaper00053302:zidovudine_72h_regulated
			WBPaper00053388:dauer_regulated_Cluster4
			WBPaper00053599:female_vs_male_upregulated
			WBPaper00053599:oocyte_vs_mitosis_downregulated
			WBPaper00053810:daf-2(e1370)_downregulated
			WBPaper00055334:DLC-1_interacting
			WBPaper00055354:Rapamycin_upregulated
			WBPaper00055565:AVK_enriched
			WBPaper00055648:germline_expressed
			WBPaper00055971:nhl-2(ok818)_25C_upregulated
			WBPaper00056034:pals-22(jy3)_downregulated
			WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
			WBPaper00056284:ints-5(RNAi)_downregulated
			WBPaper00056471:S.aureus-4h_downregulated_N2
			WBPaper00058598:sin-3(tm1276)_upregulated
			WBPaper00058691:cfp-1(tm6369)_upregulated
			WBPaper00058691:sin-3(tm1276)_upregulated
			WBPaper00059664:srbc-48(ac23)_downregulated
			WBPaper00059987:Wounding_downregulated
			WBPaper00060661:sensory-neuron_depleted
			WBPaper00060683:hlh-11(ko1)_downregulated
			WBPaper00061007:S.aquatilis_downregulated
			WBPaper00061203:sin-3(tm1276)_downregulated
			WBPaper00061203:spr-1(ok2144)_downregulated
			WBPaper00061527:cyy-1_3136-hcf-1_2478
			WBPaper00061527:pch-2-B0393.3
			WBPaper00062159:hda-2(ok1479)_downregulated
			WBPaper00064071:NHR-49_interacting
			WBPaper00064315:mrg-1(qa6200)_downregulated_PGCs
			WBPaper00064502:spe-44(fx110)_upregulated
			WBPaper00064716:paraquat_upregulated
			WBPaper00065096:25C_vs_20C_upregulated
			WBPaper00065096:Day10_vs_Day1_upregulated
			WBPaper00065975:P-body_vs_oocyte_enriched
			WBPaper00065975:P-body_vs_WholeAnimal_enriched
			WBPaper00065993:glp-1(e2141)_downregulated
			WBPaper00066110:Doxorubicin_downregulated_diploid
			WBPaper00066110:tetraploid_vs_diploid_downregulated
			WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
			cgc4489_group_5
			WBPaper00025032:cluster_81
			WBPaper00025141:N2_Expressed_Genes
			WBPaper00025141:unc-4::GFP_Enriched_Genes
			WBPaper00025141:unc-4::GFP_Expressed_Genes
			WBPaper00026929:Resveratrol_regulated_daf-16
			WBPaper00030839:Embryo_A_Class
			WBPaper00030839:Embryo_Pan_Neuronal
			WBPaper00031060:2-deoxy-D-glucose_downregulated
			WBPaper00031252:AIN-2_IP_enriched
			WBPaper00031532:Larva_Pan_Neuronal_Enriched
			WBPaper00032165:differentially_expressed_with_age_medoid_3
			WBPaper00035084:embryo_enriched_AIN-2_IP
			WBPaper00035084:L1_enriched_AIN-2_IP
			WBPaper00035084:L2_enriched_AIN-2_IP
			WBPaper00035084:L3_enriched_AIN-2_IP
			WBPaper00035873:dpy-10_regulated
			WBPaper00035905:FBF-1_Associated
			WBPaper00036130:mir-243_down_regulated
			WBPaper00036286:Pattern_F
			WBPaper00038060:SUMO-1_upregulated
			WBPaper00040963:TA300_down
			WBPaper00040985:AIN-2_L4_intestine
			WBPaper00041002:HF_3d_0.2mM_Down
			WBPaper00041002:HF_3d_2.0mM_Down
			WBPaper00041606:CE_S.marcescens_regulated
			WBPaper00041606:CE_X.nematophila_regulated
			WBPaper00041939:EtBr-exposed_vs_UVC-exposed_24h
			WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
			WBPaper00042548:miRISC_enriched
			WBPaper00045263:0.1mM-paraquat_upregulated
			WBPaper00048989:N2_rapamycin_downregulated
			WBPaper00056330:mrps-5(RNAi)_downregulated
			WBPaper00057098:SiO2-nanoparticles_upregulated
			[cgc5767]:expression_class_M
			[cgc5767]:expression_class_MD
			[cgc5767]:expression_class_MD_pd(53_min)
			[cgc5767]:expression_class_SM
			[cgc5767]:expression_class_SMD
			[cgc6390]:Cluster_E
			[cgc6390]:mixed_oogenesis-somatic
		Interaction (16)
	Map_info	Map	IV	Position	3.93215	Error	0.002647
		Positive	Positive_clone	F08B4	Inferred_automatically	From CDS info
						From sequence, transcript, pseudogene data
		Mapping_data	Multi_point	4874
				4940
		Pseudo_map_position
	Reference (12)
	Remark	Sequence connection from [Turnbull J, Kinnunen T]. krb 13/11/01
		Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.	CGC_data_submission
	Method	Gene