WormBase Tree Display for Gene: WBGene00004042
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| WBGene00004042 | SMap | S_parent | Sequence | C14B9 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | plk-1 | Person_evidence | WBPerson205 | |||||
| Sequence_name | C14B9.4 | ||||||||
| Molecular_name | C14B9.4 | ||||||||
| C14B9.4.1 | |||||||||
| CE26649 | |||||||||
| Other_name | plc1 | Accession_evidence | EMBL | AF057165 | |||||
| CELE_C14B9.4 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | plk-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | plk | ||||||||
| Allele (38) | |||||||||
| Strain | WBStrain00036529 | ||||||||
| WBStrain00007114 | |||||||||
| WBStrain00007364 | |||||||||
| WBStrain00029235 | |||||||||
| WBStrain00022403 | |||||||||
| WBStrain00022408 | |||||||||
| WBStrain00022414 | |||||||||
| WBStrain00022416 | |||||||||
| WBStrain00054974 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (58) | |||||||||
| Ortholog (42) | |||||||||
| Paralog | WBGene00004043 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00004044 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | plk-1 encodes a serine/threonine polo-like kinase homologous to Drosophila polo and Saccharomyces cerevisiae CDC5; during development, plk-1 functions to regulate meiotic cell cycle progression as well as embryonic cytoplasmic polarity in newly fertilized embryos and possibly germline development; specifically, plk-1 is required for meiotic nuclear envelope breakdown, polar body formation and extrusion, and proper chromosome segregation during meiosis possibly via phosphorylation and subsequent degradation of REC-8, a meiotic-specific cohesin; in regulating embryonic polarity, PLK-1 functions to regulate activity of the MEX-5/6 zinc-finger proteins, with which it interacts, via its polo box domain, in yeast two-hybrid assays; PLK-1 is localized diffusely in the cytoplasm of mature oocytes, but during meiosis I becomes associated with pre-metaphase chromatin and then at anaphase with chromatin and the area between dividing chromatin; in embryos, PLK-1 localizes to the cytoplasm of somatic blastomeres and during mitosis, to centrosomes, metaphase chromatin and, at telophase, to the area between dividing chromatin; the asymmetric localization of PLK-1 to somatic cytoplasm of early embryos is dependent upon the PAR proteins and MEX-5/6. | Paper_evidence | WBPaper00004215 | |||||
| WBPaper00031434 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 12 Aug 2008 00:00:00 | ||||||||
| Automated_description | Enables protein serine/threonine kinase activity. Involved in organelle organization; positive regulation of nematode male tail tip morphogenesis; and regulation of cell cycle. Located in several cellular components, including condensed chromosome; microtubule cytoskeleton; and nucleus. Expressed in AB and embryonic cell. Human ortholog(s) of this gene implicated in several diseases, including breast carcinoma; reproductive organ cancer (multiple); and urinary bladder cancer. Is an ortholog of human PLK1 (polo like kinase 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10286 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9077) | ||||
| DOID:289 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9077) | ||||||
| DOID:11054 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9077) | ||||||
| DOID:2152 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9077) | ||||||
| DOID:3459 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9077) | ||||||
| Molecular_info | Corresponding_CDS | C14B9.4 | |||||||
| Corresponding_CDS_history | C14B9.4b:wp275 | ||||||||
| Corresponding_transcript | C14B9.4.1 | ||||||||
| Other_sequence (62) | |||||||||
| Associated_feature | WBsf645386 | ||||||||
| WBsf993240 | |||||||||
| WBsf993241 | |||||||||
| WBsf1015356 | |||||||||
| WBsf1015357 | |||||||||
| WBsf225347 | |||||||||
| Experimental_info | RNAi_result (32) | ||||||||
| Expr_pattern (17) | |||||||||
| Drives_construct | WBCnstr00020528 | ||||||||
| WBCnstr00020529 | |||||||||
| WBCnstr00035725 | |||||||||
| Construct_product | WBCnstr00004713 | ||||||||
| WBCnstr00004714 | |||||||||
| WBCnstr00004715 | |||||||||
| WBCnstr00004716 | |||||||||
| WBCnstr00004730 | |||||||||
| WBCnstr00007535 | |||||||||
| WBCnstr00020528 | |||||||||
| WBCnstr00020529 | |||||||||
| WBCnstr00035725 | |||||||||
| Antibody | WBAntibody00000294 | ||||||||
| WBAntibody00001379 | |||||||||
| WBAntibody00002275 | |||||||||
| WBAntibody00002743 | |||||||||
| WBAntibody00002789 | |||||||||
| WBAntibody00002892 | |||||||||
| WBAntibody00002960 | |||||||||
| Microarray_results (25) | |||||||||
| Expression_cluster (204) | |||||||||
| SAGE_tag (19) | |||||||||
| Interaction (1090) | |||||||||
| WBProcess | WBbiopr:00000068 | ||||||||
| Map_info | Map | III | Position | -0.377121 | Error | 0.000162 | |||
| Positive | Positive_clone | C14B9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| K06H7 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (86) | |||||||||
| Remark | annotated as plc1 in the EMBLGenbank record. sdm 12/00 | ||||||||
| K06H7.1 removed. sdm 12/00 | |||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
