WormBase Tree Display for Gene: WBGene00004043
expand all nodes | collapse all nodes | view schema
| WBGene00004043 | SMap | S_parent | Sequence | Y71F9B | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | plk-2 | Person_evidence | WBPerson205 | |||||
| Sequence_name | Y71F9B.7 | ||||||||
| Molecular_name | Y71F9B.7 | ||||||||
| Y71F9B.7.1 | |||||||||
| CE22877 | |||||||||
| Other_name | CELE_Y71F9B.7 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | plk-2 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | plk | ||||||||
| Allele (78) | |||||||||
| Strain | WBStrain00032279 | ||||||||
| WBStrain00047219 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (35) | |||||||||
| Contained_in_operon | CEOP1060 | ||||||||
| Ortholog (33) | |||||||||
| Paralog | WBGene00004042 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00004044 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | plk-2 encodes one of three C. elegans polo-like kinases; in the developing germ line, PLK-2 activity is required for regulation of chromosome dynamics that result in recruitment and attachment of meiotic chromosomes to the nuclear envelope and cytoskeleton; in the early embryo, PLK-2 activity is required for regulating the function of MEX-5/6, zinc-finger proteins essential for embryonic polarity and with which PLK-2 interacts, via its polo box domain, in yeast two-hybrid assays; PLK-2 is expressed in the meiotic germ line where it initially localizes to pairing centers and later localizes to synaptonemal complexes and in early embryos where it localizes asymmetrically to the cytoplasm of somatic blastomeres; in the mitotic germline faint PLK-2 is seen faintly centrosomes and kinetochores. | Paper_evidence | WBPaper00031434 | |||||
| WBPaper00040347 | |||||||||
| WBPaper00040348 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 14 Feb 2012 00:00:00 | ||||||||
| Automated_description | Predicted to enable protein serine/threonine kinase activity. Involved in regulation of meiosis I. Located in cytoplasm. Expressed in germ line. Human ortholog(s) of this gene implicated in several diseases, including breast carcinoma; reproductive organ cancer (multiple); and urinary bladder cancer. Is an ortholog of human PLK1 (polo like kinase 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10286 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9077) | ||||
| DOID:289 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9077) | ||||||
| DOID:11054 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9077) | ||||||
| DOID:2152 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9077) | ||||||
| DOID:3459 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9077) | ||||||
| Molecular_info | Corresponding_CDS | Y71F9B.7 | |||||||
| Corresponding_transcript | Y71F9B.7.1 | ||||||||
| Other_sequence (36) | |||||||||
| Associated_feature | WBsf982969 | ||||||||
| WBsf982970 | |||||||||
| WBsf982971 | |||||||||
| WBsf982972 | |||||||||
| WBsf1009399 | |||||||||
| WBsf1009400 | |||||||||
| WBsf219059 | |||||||||
| WBsf219060 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00062543 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00037783 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00108302 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00058184 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00116534 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr7874 | ||||||||
| Expr9847 | |||||||||
| Expr9849 | |||||||||
| Expr14834 | |||||||||
| Expr1028150 | |||||||||
| Expr1031943 | |||||||||
| Expr1161603 | |||||||||
| Expr2014959 | |||||||||
| Expr2033194 | |||||||||
| Antibody | WBAntibody00001365 | ||||||||
| WBAntibody00002274 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (128) | |||||||||
| Interaction (213) | |||||||||
| Map_info | Map | I | Position | -7.26598 | Error | 0.016083 | |||
| Positive | Positive_clone | F55G1 | |||||||
| Y71F9B | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | Multi_point | 4867 | |||||||
| 4835 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (36) | |||||||||
| Remark | Sequence connection updated based on email from John Spieth citing GB:AF194964. Previous connection was to F55G1.8 | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
