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WormBase Tree Display for Gene: WBGene00004303

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Name Class

WBGene00004303SMapS_parentSequenceC29E4
IdentityVersion2
NameCGC_nameran-2
Sequence_nameC29E4.3
Molecular_nameC29E4.3a
C29E4.3a.1
CE37483
C29E4.3b
CE30621
C29E4.3b.1
C29E4.3b.2
Other_namepna-3Person_evidenceWBPerson561
CELE_C29E4.3Accession_evidenceNDBBX284603
Public_nameran-2
DB_infoDatabaseAceViewgene3J25
WormQTLgeneWBGene00004303
WormFluxgeneWBGene00004303
NDBlocus_tagCELE_C29E4.3
PanthergeneCAEEL|WormBase=WBGene00004303|UniProtKB=P34342
familyPTHR24113
NCBIgene176115
RefSeqproteinNM_171884.5
NM_171198.8
SwissProtUniProtAccP34342
TREEFAMTREEFAM_IDTF318283
UniProt_GCRPUniProtAccP34342
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:34WBPerson1971EventImportedInitial conversion from geneace
206 Jul 2015 11:34:19WBPerson2970EventAcquires_mergeWBGene00004067
Name_changeOther_namepna-3
Acquires_mergeWBGene00004067
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classran
Allele (51)
Legacy_information[Schnabel H] maternal effect embryonic lethal with abnormal pronuclear apppearance
StrainWBStrain00036599
WBStrain00007779
RNASeq_FPKM (74)
GO_annotation (12)
Contained_in_operonCEOP3465
Ortholog (48)
Structured_descriptionConcise_descriptionran-2 encodes the C. elegans RanGAP (GTPase activating protein) homolog, conserved amongst yeast, Drosophila (segregation distorter), Xenopus, and humans; by homology, RAN-2 is predicted to function as a key regulator of the Ran GTP/GDP cycle by stimulating the otherwise weak Ran GTPase activity; in C. elegans, RAN-2 activity is essential during early embryogenesis for comigration of centrosomes with the male pronucleus, mitotic spindle formation, chromosome segregation, and nuclear envelope assembly; in addition, RAN-2 is also required for nucleocytoplasmic transport; ran-2 reporter gene expression is detected in embryos and larvae.Paper_evidenceWBPaper00004403
WBPaper00004651
WBPaper00005178
WBPaper00005637
WBPaper00011686
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionPredicted to enable GTPase activator activity and small GTPase binding activity. Involved in embryo development. Predicted to be located in cytosol; nucleus; and perinuclear region of cytoplasm. Expressed in intestinal cell. Is an ortholog of human RANGAP1 (Ran GTPase activating protein 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS290 version of WormBase
Date_last_updated11 Sep 2023 00:00:00
Molecular_infoCorresponding_CDSC29E4.3a
C29E4.3b
Corresponding_CDS_historyC29E4.3a:wp130
Corresponding_transcriptC29E4.3a.1
C29E4.3b.1
C29E4.3b.2
Other_sequence (24)
Associated_featureWBsf645370
WBsf645371
WBsf976236
WBsf976237
WBsf225302
WBsf225303
WBsf225304
WBsf225305
Experimental_infoRNAi_resultWBRNAi00085739Inferred_automaticallyRNAi_primary
WBRNAi00062934Inferred_automaticallyRNAi_primary
WBRNAi00062949Inferred_automaticallyRNAi_primary
WBRNAi00001007Inferred_automaticallyRNAi_primary
WBRNAi00041448Inferred_automaticallyRNAi_primary
WBRNAi00086891Inferred_automaticallyRNAi_primary
WBRNAi00062955Inferred_automaticallyRNAi_primary
WBRNAi00002456Inferred_automaticallyRNAi_primary
WBRNAi00062942Inferred_automaticallyRNAi_primary
WBRNAi00065354Inferred_automaticallyRNAi_primary
Expr_patternExpr2038
Expr1026981
Expr1032128
Expr1145479
Expr2015251
Expr2033485
Microarray_results (20)
Expression_cluster (115)
Interaction (111)
Map_infoMapIIIPosition-0.48356Error0.002198
PositivePositive_cloneC29E4Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Pseudo_map_position
Reference (11)
RemarkSequence connection from [Askjaer P, Mattaj IW]. krb 13/11/01
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene