WormBase Tree Display for Gene: WBGene00020891
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| WBGene00020891 | SMap | S_parent | Sequence | T28C12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | cest-24 | Person_evidence | WBPerson36909 | |||||
| WBPerson7188 | |||||||||
| Sequence_name | T28C12.4 | ||||||||
| Molecular_name | T28C12.4a | ||||||||
| T28C12.4a.1 | |||||||||
| CE14343 | |||||||||
| T28C12.4b | |||||||||
| CE14345 | |||||||||
| T28C12.4a.2 | |||||||||
| T28C12.4b.1 | |||||||||
| T28C12.4b.2 | |||||||||
| Other_name | CELE_T28C12.4 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | cest-24 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:31:03 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 20 May 2019 14:10:26 | WBPerson1983 | Name_change | CGC_name | cest-24 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | cest | ||||||||
| Allele (128) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00028487 | ||||||||
| 00028488 | |||||||||
| 00028489 | |||||||||
| 00028490 | |||||||||
| Ortholog (36) | |||||||||
| Paralog (41) | |||||||||
| Structured_description | Concise_description | T28C12.4 encodes a protein with visible similarity to human neuroligin 4 (mutated in autism), but also belongs to a large family of carboxylesterases that happen to include NLG-1; normally, T28C12.4 is expressed in hypodermal cells; transcription of T28C12.4 is immediately induced by exposure to ethanol, and with glr-2 is one of a few genes that may be specifically responsive to ethanol (as opposed to other stresses, which are expected to typically induce heat shock genes); the 5' flank of T28C12.4 contains a single ethanol- and stress-responsive element that is required in a T28C12.4::GFP transgene for transcriptional induction by ethanol. | Paper_evidence | WBPaper00006465 | |||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 11 Feb 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable carboxylic ester hydrolase activity. Expressed in hypodermis and seam cell. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Disease_relevance | Human liver carboxylesterases, CES1, CES2 and CES3 (orthologous to C. elegans T28C12.4), metabolize and detoxify drugs and toxins; CESs metabolize ester, thioester, carbamate and amide compounds to acid, alcohol and amine products; mutations in CES1 are associated with Carboxylesterase 1 deficiency. | Homo sapiens | Accession_evidence | OMIM | 114835 | |||
| 605278 | |||||||||
| 605279 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 26 Jun 2012 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | T28C12.4a | |||||||
| T28C12.4b | |||||||||
| Corresponding_transcript | T28C12.4a.1 | ||||||||
| T28C12.4a.2 | |||||||||
| T28C12.4b.1 | |||||||||
| T28C12.4b.2 | |||||||||
| Other_sequence (41) | |||||||||
| Associated_feature | WBsf646872 | ||||||||
| WBsf646873 | |||||||||
| WBsf661326 | |||||||||
| WBsf661327 | |||||||||
| WBsf661328 | |||||||||
| WBsf661329 | |||||||||
| WBsf1000225 | |||||||||
| WBsf1000226 | |||||||||
| WBsf231867 | |||||||||
| WBsf231868 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00054391 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00019384 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089171 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00036074 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr2907 | ||||||||
| Expr1019072 | |||||||||
| Expr1039101 | |||||||||
| Expr1157938 | |||||||||
| Expr2006605 | |||||||||
| Expr2024821 | |||||||||
| Drives_construct | WBCnstr00011018 | ||||||||
| WBCnstr00024806 | |||||||||
| Construct_product | WBCnstr00024806 | ||||||||
| Microarray_results (25) | |||||||||
| Expression_cluster (203) | |||||||||
| Interaction (33) | |||||||||
| Map_info | Map | V | Position | -0.18384 | |||||
| Positive | Positive_clone | T28C12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00006465 | ||||||||
| WBPaper00010030 | |||||||||
| WBPaper00016665 | |||||||||
| WBPaper00032322 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
