WormBase Tree Display for Gene: WBGene00006961
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WBGene00006961 | SMap | S_parent | Sequence | B0041 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||||
Name | CGC_name | xnp-1 | |||||||
Sequence_name | B0041.7 | ||||||||
Molecular_name | B0041.7 | ||||||||
B0041.7.1 | |||||||||
CE17314 | |||||||||
Other_name | slr-8 | Paper_evidence | WBPaper00024322 | ||||||
CELE_B0041.7 | Accession_evidence | NDB | BX284601 | ||||||
Public_name | xnp-1 | ||||||||
DB_info | Database (13) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:44 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
2 | 10 Sep 2004 08:52:53 | WBPerson1971 | Name_change | Other_name | slr-8 | ||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | xnp | ||||||||
Allele (68) | |||||||||
Strain | WBStrain00002007 | ||||||||
WBStrain00002321 | |||||||||
WBStrain00037072 | |||||||||
WBStrain00040593 | |||||||||
WBStrain00021973 | |||||||||
Component_of_genotype | WBGenotype00000009 | ||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (20) | |||||||||
Ortholog (38) | |||||||||
Paralog (19) | |||||||||
Structured_description | Concise_description | xnp-1 encodes an ATP-dependent DNA helicase of the SNF2 family that is orthologous to human XNP/ATR-X, which is associated with a number of X-linked mental retardation syndromes; in C. elegans, xnp-1 activity is required at high temperatures for embryogenesis, somatic gonad development, fertility, and vulval morphogenesis; in addition, animals doubly mutant for xnp-1 and lin-35/Rb, hpl-2/HP1, or nucleosome remodelling and histone deacetylase (NuRD) complex members such as lin-53 and let-418, display larval arrest with growth cessation but continued cell proliferation; xnp-1 is also required, with lin-35/Rb and hpl-2/HP1, for proper regulation of transgene expression; xnp-1 mRNA, detectable in embryos and the germline by in situ hybridization, is expressed at highest levels in embryos with decreasing levels seen in successive larval stages; xnp-1 transcriptional reporter fusions exhibit strong expression beginning at mid-embryogenesis but fading by embryonic morphogenesis; at hatching, expression is observed in all dividing cells including the P lineage, and at later larval stages expression is observed in the vulval precursor cells. | Paper_evidence | WBPaper00004103 | |||||
WBPaper00024322 | |||||||||
WBPaper00024692 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
WBPerson1823 | |||||||||
WBPerson567 | |||||||||
Date_last_updated | 27 Apr 2006 00:00:00 | ||||||||
Automated_description | Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and catalytic activity, acting on a nucleic acid. Involved in several processes, including embryo development; gonad development; and vulval development. Predicted to be located in nucleus. Expressed in germ line; hermaphrodite gonad; and vulval precursor cell. Used to study intellectual disability. Human ortholog(s) of this gene implicated in several diseases, including X-linked mental retardation-hypotonic facies syndrome-1; alpha thalassemia-X-linked intellectual disability syndrome; and lung carcinoma (multiple). Is an ortholog of human ATRX (ATRX chromatin remodeler). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Experimental_model | DOID:1059 | Homo sapiens | Paper_evidence | WBPaper00024322 | ||||
WBPaper00024692 | |||||||||
Accession_evidence | OMIM | 309580 | |||||||
300448 | |||||||||
301040 | |||||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 18 Apr 2013 00:00:00 | ||||||||
Potential_model (12) | |||||||||
Disease_relevance | Human ATRX encodes a protein with a ATPase/helicase domain involved in chromatin remodeling, mutations in which, have been associated with alpha-thalassemia and X-linked mental retardation; the elegans ortholog, xnp-1 is required for gonadal development and acts in association with lin-35/Retinoblastoma (RB), components of the NuRD complex and hpl-2/HP1 genes; the requirement of xnp-1 with lin-35/ Rb in larval development in C. elegans can be compared with the observation that in humans, XNP/ATR-X mutation is also associated, with short stature and skeletal abnormalities during development. | Homo sapiens | Paper_evidence | WBPaper00024322 | |||||
WBPaper00024692 | |||||||||
WBPaper00003646 | |||||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 23 Apr 2013 00:00:00 | ||||||||
Models_disease_asserted | WBDOannot00000158 | ||||||||
WBDOannot00000309 | |||||||||
WBDOannot00000614 | |||||||||
WBDOannot00001020 | |||||||||
Molecular_info | Corresponding_CDS | B0041.7 | |||||||
Corresponding_CDS_history | B0041.7a:wp115 | ||||||||
B0041.7b:wp115 | |||||||||
Corresponding_transcript | B0041.7.1 | ||||||||
Other_sequence (38) | |||||||||
Associated_feature | WBsf649115 | ||||||||
WBsf664165 | |||||||||
WBsf983463 | |||||||||
WBsf219305 | |||||||||
WBsf219306 | |||||||||
WBsf219307 | |||||||||
WBsf219308 | |||||||||
Experimental_info | RNAi_result | WBRNAi00038553 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00038550 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00038555 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00038549 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00038551 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00085664 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00038691 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00038552 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00075558 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00038554 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern (11) | |||||||||
Drives_construct | WBCnstr00002790 | ||||||||
WBCnstr00004416 | |||||||||
WBCnstr00006334 | |||||||||
WBCnstr00011208 | |||||||||
WBCnstr00034068 | |||||||||
Construct_product | WBCnstr00011208 | ||||||||
WBCnstr00034068 | |||||||||
Microarray_results (21) | |||||||||
Expression_cluster (117) | |||||||||
Interaction (20) | |||||||||
Map_info | Map | I | Position | -1.02154 | Error | 0.001984 | |||
Positive | Positive_clone | B0041 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 4204 | |||||||
5492 | |||||||||
Pseudo_map_position | |||||||||
Reference (19) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |