WormBase Tree Display for Gene: WBGene00006961
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| WBGene00006961 | SMap | S_parent | Sequence | B0041 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | xnp-1 | |||||||
| Sequence_name | B0041.7 | ||||||||
| Molecular_name | B0041.7 | ||||||||
| B0041.7.1 | |||||||||
| CE17314 | |||||||||
| Other_name | slr-8 | Paper_evidence | WBPaper00024322 | ||||||
| CELE_B0041.7 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | xnp-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:44 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 10 Sep 2004 08:52:53 | WBPerson1971 | Name_change | Other_name | slr-8 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | xnp | ||||||||
| Allele | WBVar00249710 | ||||||||
| WBVar01431446 | |||||||||
| WBVar01431447 | |||||||||
| WBVar01431448 | |||||||||
| WBVar00633541 | |||||||||
| WBVar01499919 | |||||||||
| WBVar00633542 | |||||||||
| WBVar00633543 | |||||||||
| WBVar00633544 | |||||||||
| WBVar00633545 | |||||||||
| WBVar00633546 | |||||||||
| WBVar00633547 | |||||||||
| WBVar00633548 | |||||||||
| WBVar00633549 | |||||||||
| WBVar00633550 | |||||||||
| WBVar00633551 | |||||||||
| WBVar00070824 | |||||||||
| WBVar00633552 | |||||||||
| WBVar00275610 | |||||||||
| WBVar00633553 | |||||||||
| WBVar00633554 | |||||||||
| WBVar01846459 | |||||||||
| WBVar00633555 | |||||||||
| WBVar00633556 | |||||||||
| WBVar00633557 | |||||||||
| WBVar00633558 | |||||||||
| WBVar00633559 | |||||||||
| WBVar00633560 | |||||||||
| WBVar01282463 | |||||||||
| WBVar01499786 | |||||||||
| WBVar00597744 | |||||||||
| WBVar01993187 | |||||||||
| WBVar01993188 | |||||||||
| WBVar01499985 | |||||||||
| WBVar01499818 | |||||||||
| WBVar01499819 | |||||||||
| WBVar00145332 | |||||||||
| WBVar00332940 | |||||||||
| WBVar00332941 | |||||||||
| WBVar00332942 | |||||||||
| WBVar00332943 | |||||||||
| WBVar00332944 | |||||||||
| WBVar00332945 | |||||||||
| WBVar00153271 | |||||||||
| WBVar00332946 | |||||||||
| WBVar01315250 | |||||||||
| WBVar00153272 | |||||||||
| WBVar00332947 | |||||||||
| WBVar00332948 | |||||||||
| WBVar00153273 | |||||||||
| WBVar00332949 | |||||||||
| WBVar00153274 | |||||||||
| WBVar00332950 | |||||||||
| WBVar00153275 | |||||||||
| WBVar00332951 | |||||||||
| WBVar00332952 | |||||||||
| WBVar00332953 | |||||||||
| WBVar02055590 | |||||||||
| WBVar00536824 | |||||||||
| WBVar01398973 | |||||||||
| WBVar01573974 | |||||||||
| WBVar02127209 | |||||||||
| WBVar02127210 | |||||||||
| WBVar01418423 | |||||||||
| WBVar02127211 | |||||||||
| WBVar01418434 | |||||||||
| WBVar01498959 | |||||||||
| WBVar00093021 | |||||||||
| Strain | WBStrain00002007 | ||||||||
| WBStrain00002321 | |||||||||
| WBStrain00037072 | |||||||||
| WBStrain00040593 | |||||||||
| WBStrain00021973 | |||||||||
| Component_of_genotype | WBGenotype00000009 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (20) | |||||||||
| Ortholog (38) | |||||||||
| Paralog (19) | |||||||||
| Structured_description | Concise_description | xnp-1 encodes an ATP-dependent DNA helicase of the SNF2 family that is orthologous to human XNP/ATR-X, which is associated with a number of X-linked mental retardation syndromes; in C. elegans, xnp-1 activity is required at high temperatures for embryogenesis, somatic gonad development, fertility, and vulval morphogenesis; in addition, animals doubly mutant for xnp-1 and lin-35/Rb, hpl-2/HP1, or nucleosome remodelling and histone deacetylase (NuRD) complex members such as lin-53 and let-418, display larval arrest with growth cessation but continued cell proliferation; xnp-1 is also required, with lin-35/Rb and hpl-2/HP1, for proper regulation of transgene expression; xnp-1 mRNA, detectable in embryos and the germline by in situ hybridization, is expressed at highest levels in embryos with decreasing levels seen in successive larval stages; xnp-1 transcriptional reporter fusions exhibit strong expression beginning at mid-embryogenesis but fading by embryonic morphogenesis; at hatching, expression is observed in all dividing cells including the P lineage, and at later larval stages expression is observed in the vulval precursor cells. | Paper_evidence | WBPaper00004103 | |||||
| WBPaper00024322 | |||||||||
| WBPaper00024692 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 27 Apr 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and catalytic activity, acting on a nucleic acid. Involved in several processes, including embryo development; gonad development; and vulval development. Predicted to be located in nucleus. Expressed in germ line; hermaphrodite gonad; and vulval precursor cell. Used to study intellectual disability. Human ortholog(s) of this gene implicated in several diseases, including X-linked mental retardation-hypotonic facies syndrome-1; alpha thalassemia-X-linked intellectual disability syndrome; and lung carcinoma (multiple). Is an ortholog of human ATRX (ATRX chromatin remodeler). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:1059 | Homo sapiens | Paper_evidence | WBPaper00024322 | ||||
| WBPaper00024692 | |||||||||
| Accession_evidence | OMIM | 309580 | |||||||
| 300448 | |||||||||
| 301040 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 18 Apr 2013 00:00:00 | ||||||||
| Potential_model (12) | |||||||||
| Disease_relevance | Human ATRX encodes a protein with a ATPase/helicase domain involved in chromatin remodeling, mutations in which, have been associated with alpha-thalassemia and X-linked mental retardation; the elegans ortholog, xnp-1 is required for gonadal development and acts in association with lin-35/Retinoblastoma (RB), components of the NuRD complex and hpl-2/HP1 genes; the requirement of xnp-1 with lin-35/ Rb in larval development in C. elegans can be compared with the observation that in humans, XNP/ATR-X mutation is also associated, with short stature and skeletal abnormalities during development. | Homo sapiens | Paper_evidence | WBPaper00024322 | |||||
| WBPaper00024692 | |||||||||
| WBPaper00003646 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 23 Apr 2013 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000158 | ||||||||
| WBDOannot00000309 | |||||||||
| WBDOannot00000614 | |||||||||
| WBDOannot00001020 | |||||||||
| Molecular_info | Corresponding_CDS | B0041.7 | |||||||
| Corresponding_CDS_history | B0041.7a:wp115 | ||||||||
| B0041.7b:wp115 | |||||||||
| Corresponding_transcript | B0041.7.1 | ||||||||
| Other_sequence (38) | |||||||||
| Associated_feature | WBsf649115 | ||||||||
| WBsf664165 | |||||||||
| WBsf983463 | |||||||||
| WBsf219305 | |||||||||
| WBsf219306 | |||||||||
| WBsf219307 | |||||||||
| WBsf219308 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00038553 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00038550 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00038555 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00038549 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00038551 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00085664 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00038691 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00038552 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00075558 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00038554 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00002790 | ||||||||
| WBCnstr00004416 | |||||||||
| WBCnstr00006334 | |||||||||
| WBCnstr00011208 | |||||||||
| WBCnstr00034068 | |||||||||
| Construct_product | WBCnstr00011208 | ||||||||
| WBCnstr00034068 | |||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (117) | |||||||||
| Interaction (20) | |||||||||
| Map_info | Map | I | Position | -1.02154 | Error | 0.001984 | |||
| Positive | Positive_clone | B0041 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4204 | |||||||
| 5492 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (19) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
