WormBase Tree Display for Gene: WBGene00002003
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| WBGene00002003 | SMap | S_parent | Sequence | B0285 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | hse-5 | Person_evidence | WBPerson260 | |||||
| Sequence_name | B0285.5 | ||||||||
| Molecular_name | B0285.5 | ||||||||
| B0285.5.1 | |||||||||
| CE36681 | |||||||||
| B0285.5.2 | |||||||||
| B0285.5.3 | |||||||||
| Other_name | CELE_B0285.5 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | hse-5 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | hse | ||||||||
| Allele (57) | |||||||||
| Strain | WBStrain00029322 | ||||||||
| WBStrain00032590 | |||||||||
| WBStrain00040542 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (20) | |||||||||
| Contained_in_operon | CEOP3174 | ||||||||
| Ortholog (50) | |||||||||
| Structured_description | Concise_description | hse-5 encodes the C. elegans ortholog of the heparan sulfate modifying enzyme glucuronyl C5-epimerase; by homology, HSE-5 is predicted to function in heparan sulfate biosynthesis by catalyzing the chain-modifying epimerization of glucuronic acid to iduronic acid; during development, hse-5 activity is required for normal body size, locomotion, and nervous system development; an hse-5::gfp transcriptional reporter fusion is expressed beginning at early embryonic stages and continuing through adulthood; expression in embryos is nearly ubiquitous with later expression primarily restricted to the hypodermis and intestine. | Paper_evidence | WBPaper00006471 | |||||
| WBPaper00029002 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 26 Oct 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable heparosan-N-sulfate-glucuronate 5-epimerase activity. Involved in heparan sulfate proteoglycan biosynthetic process, enzymatic modification; regulation of cell migration; and regulation of growth. Predicted to be located in Golgi apparatus. Expressed in hypodermis. Human ortholog(s) of this gene implicated in cerebrovascular disease and hypertension. Is an ortholog of human GLCE (glucuronic acid epimerase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:6713 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17855) | ||||
| DOID:10763 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17855) | ||||||
| Molecular_info | Corresponding_CDS | B0285.5 | |||||||
| Corresponding_CDS_history | B0285.5:wp125 | ||||||||
| Corresponding_transcript | B0285.5.1 | ||||||||
| B0285.5.2 | |||||||||
| B0285.5.3 | |||||||||
| Other_sequence (27) | |||||||||
| Associated_feature | WBsf658816 | ||||||||
| WBsf992098 | |||||||||
| WBsf224717 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00066074 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00005074 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00067661 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00062088 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00038875 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00009668 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00102098 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00103141 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00028061 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr2903 | ||||||||
| Expr12190 | |||||||||
| Expr1025363 | |||||||||
| Expr1031168 | |||||||||
| Expr1143063 | |||||||||
| Expr2012609 | |||||||||
| Expr2030845 | |||||||||
| Drives_construct | WBCnstr00011016 | ||||||||
| WBCnstr00016118 | |||||||||
| WBCnstr00020397 | |||||||||
| WBCnstr00036528 | |||||||||
| Construct_product | WBCnstr00036528 | ||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (118) | |||||||||
| Interaction (17) | |||||||||
| Anatomy_function | WBbtf0283 | ||||||||
| Map_info | Map | III | Position | -3.18467 | Error | 0.000861 | |||
| Positive | Positive_clone | B0285 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (23) | |||||||||
| Remark | Sequence connection from [Buelow H, Hobert O] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
