WormBase Tree Display for Gene: WBGene00002147
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| WBGene00002147 | SMap | S_parent | Sequence | C41C4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | ire-1 | Person_evidence | WBPerson159 | |||||
| Sequence_name | C41C4.4 | ||||||||
| Molecular_name | C41C4.4a | ||||||||
| C41C4.4a.1 | |||||||||
| CE35836 | |||||||||
| C41C4.4b | |||||||||
| CE45635 | |||||||||
| C41C4.4b.1 | |||||||||
| Other_name | CELE_C41C4.4 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | ire-1 | ||||||||
| DB_info | Database (14) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ire | ||||||||
| Allele (160) | |||||||||
| Strain | WBStrain00031637 | ||||||||
| WBStrain00033316 | |||||||||
| WBStrain00034062 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (56) | |||||||||
| Ortholog (54) | |||||||||
| Structured_description | Concise_description | ire-1 encodes a transmembrane serine/threonine protein kinase and site-specific endoribonuclease orthologous to Saccharomyces cerevisiae inositol-requiring 1 protein kinase (Ire1) and human endoplasmic reticulum-to-nucleus signaling 1 (ERN1, OMIM:604033); IRE-1 is required for the unfolded protein response (UPR) that counteracts cellular stress induced by accumulation of unfolded proteins in the endoplasmic reticulum (ER); in response to ER stress, IRE-1 cleaves xbp-1 mRNA to produce transcriptionally active XBP-1 that positively regulates UPR gene expression in order to maintain ER homeostasis. | Paper_evidence | WBPaper00005036 | |||||
| WBPaper00005044 | |||||||||
| WBPaper00005432 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables RNA endonuclease activity. Involved in nematode larval development; response to endoplasmic reticulum stress; and response to hypoxia. Acts upstream of with a positive effect on IRE1-mediated unfolded protein response and intrinsic apoptotic signaling pathway by p53 class mediator. Located in neuronal cell body. Expressed widely. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and oropharynx cancer. Is an ortholog of human ERN2 (endoplasmic reticulum to nucleus signaling 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3449) | ||||
| DOID:8557 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3449) | ||||||
| Molecular_info | Corresponding_CDS | C41C4.4a | |||||||
| C41C4.4b | |||||||||
| Corresponding_CDS_history | C41C4.4:wp111 | ||||||||
| Corresponding_transcript | C41C4.4a.1 | ||||||||
| C41C4.4b.1 | |||||||||
| Other_sequence (32) | |||||||||
| Associated_feature (18) | |||||||||
| Gene_product_binds | WBsf977530 | ||||||||
| Experimental_info | RNAi_result (44) | ||||||||
| Expr_pattern | Expr3423 | ||||||||
| Expr1014693 | |||||||||
| Expr1031261 | |||||||||
| Expr1146268 | |||||||||
| Expr2012815 | |||||||||
| Expr2031054 | |||||||||
| Drives_construct | WBCnstr00011391 | ||||||||
| WBCnstr00036417 | |||||||||
| Construct_product | WBCnstr00036417 | ||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (119) | |||||||||
| Interaction (259) | |||||||||
| WBProcess | WBbiopr:00000030 | ||||||||
| WBbiopr:00000046 | |||||||||
| WBbiopr:00000079 | |||||||||
| WBbiopr:00000121 | |||||||||
| Map_info | Map | II | Position | 0.681931 | Error | 0.002224 | |||
| Positive | Positive_clone | C41C4 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (124) | |||||||||
| Remark | Sequence connection from [Ron D]. krb 14/11/01 | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
