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WormBase Tree Display for Gene: WBGene00002147

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Name Class

WBGene00002147SMapS_parentSequenceC41C4
IdentityVersion1
NameCGC_nameire-1Person_evidenceWBPerson159
Sequence_nameC41C4.4
Molecular_nameC41C4.4a
C41C4.4a.1
CE35836
C41C4.4b
CE45635
C41C4.4b.1
Other_nameCELE_C41C4.4Accession_evidenceNDBBX284602
Public_nameire-1
DB_infoDatabase (14)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:26WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classire
Allele (160)
StrainWBStrain00031637
WBStrain00033316
WBStrain00034062
RNASeq_FPKM (74)
GO_annotation (56)
Ortholog (54)
Structured_descriptionConcise_descriptionire-1 encodes a transmembrane serine/threonine protein kinase and site-specific endoribonuclease orthologous to Saccharomyces cerevisiae inositol-requiring 1 protein kinase (Ire1) and human endoplasmic reticulum-to-nucleus signaling 1 (ERN1, OMIM:604033); IRE-1 is required for the unfolded protein response (UPR) that counteracts cellular stress induced by accumulation of unfolded proteins in the endoplasmic reticulum (ER); in response to ER stress, IRE-1 cleaves xbp-1 mRNA to produce transcriptionally active XBP-1 that positively regulates UPR gene expression in order to maintain ER homeostasis.Paper_evidenceWBPaper00005036
WBPaper00005044
WBPaper00005432
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnables RNA endonuclease activity. Involved in nematode larval development; response to endoplasmic reticulum stress; and response to hypoxia. Acts upstream of with a positive effect on IRE1-mediated unfolded protein response and intrinsic apoptotic signaling pathway by p53 class mediator. Located in neuronal cell body. Expressed widely. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and oropharynx cancer. Is an ortholog of human ERN2 (endoplasmic reticulum to nucleus signaling 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:684Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3449)
DOID:8557Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3449)
Molecular_infoCorresponding_CDSC41C4.4a
C41C4.4b
Corresponding_CDS_historyC41C4.4:wp111
Corresponding_transcriptC41C4.4a.1
C41C4.4b.1
Other_sequence (32)
Associated_feature (18)
Gene_product_bindsWBsf977530
Experimental_infoRNAi_result (44)
Expr_patternExpr3423
Expr1014693
Expr1031261
Expr1146268
Expr2012815
Expr2031054
Drives_constructWBCnstr00011391
WBCnstr00036417
Construct_productWBCnstr00036417
Microarray_results (21)
Expression_clusterWBPaper00031040:TGF-beta_adult_downregulated
WBPaper00033065:cyc-1(RNAi)_downregulated
WBPaper00037055:DAF-16_binding_DNA
WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:all-neurons_L1-larva_expressed
WBPaper00037950:all-neurons_L2-larva_expressed
WBPaper00037950:AVA-neuron_L1-larva_expressed
WBPaper00037950:AVE-neuron_L1-larva_expressed
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:coelomocytes_L1-larva_expressed
WBPaper00037950:coelomocytes_L2-larva_expressed
WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00040221:DAF-12_target_ALF4
WBPaper00044736:flat_dev_expression
WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
WBPaper00045521:Gender_Neutral
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
WBPaper00049626:UNC-75_target
WBPaper00049732:blmp-1(tm548)_vs_N2_downregulated
WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
WBPaper00049942:hsf-1(RNAi)_upregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050990:body-muscle_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00051039:germline_enriched
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053184:sma-2(rax5)_downregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053289:DREAM-target
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053321:PGCs_enriched_NuGen
WBPaper00053599:oocyte_vs_mitosis_downregulated
WBPaper00053814:25C_downregulated_PY79
WBPaper00055648:germline_expressed
WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
WBPaper00056139:soil-microbiota_downregulated
WBPaper00056161:male_enriched_siRNA
WBPaper00056619:CEPsh_enriched
WBPaper00057288:Cold_upregulated_transcript
WBPaper00057288:iff-1(RNAi)_upregulated_transcript
WBPaper00058598:sin-3(tm1276)_upregulated
WBPaper00058691:sin-3(tm1276)_upregulated
WBPaper00059356:BAZ-2_SET-6_interacting
WBPaper00059471:EGL-43_interacting
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060683:hlh-11(ko1)_downregulated
WBPaper00060811:L1_vs_adult_downregulated_neural
WBPaper00061203:sin-3(tm1276)_downregulated
WBPaper00061203:spr-1(ok2144)_downregulated
WBPaper00061340:F_U
WBPaper00061340:g1A_g1P
WBPaper00061340:g2
WBPaper00061340:mu_int_mu_anal
WBPaper00061340:rect_D
WBPaper00061439:unc-30(ok613)_downregulated
WBPaper00061527:cyy-1_3136-hcf-1_2478
WBPaper00061527:trcs-2_5724-R11A8.7_17645
WBPaper00062159:hda-2(ok1479)_downregulated
WBPaper00062193:hsf-1(RNAi)_downregulated
WBPaper00062193:skn-1(RNAi)_downregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064716:paraquat_upregulated
WBPaper00065086:JU1400_N.ausubeli_regulated
WBPaper00065086:N2_N.ironsii_regulated
WBPaper00065096:Day10_vs_Day1_upregulated
WBPaper00065975:P-body_vs_WholeAnimal_enriched
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00066062:xrep-4(lax137)_upregulated
cgc4489_group_5
WBPaper00025032:cluster_1
WBPaper00025032:cluster_6
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:Resveratrol_regulated_daf-16
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00031003:0hr_muscle_depleted
WBPaper00031003:24hr_muscle_depleted
WBPaper00031003:total_muscle_depleted
WBPaper00031252:AIN-2_IP_enriched
WBPaper00034739:N2moreDR1350
WBPaper00035905:FBF-1_Associated
WBPaper00036286:Pattern_F
WBPaper00038231:Cry5B_1.5-fold_upregulated
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00041002:HF_3d_2.0mM_Down
WBPaper00041002:HQ_3d_2.0mM_Down
WBPaper00041606:CE_B.thuringiensis-DB27_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00045263:0.1mM-paraquat_upregulated
WBPaper00048989:N2_allantoin_upregulated
WBPaper00048989:N2_rapamycin_downregulated
[cgc5767]:expression_class_M
[cgc5767]:expression_class_MD
[cgc5767]:expression_class_MD_pd(53_min)
[cgc5767]:expression_class_MD_pd(66_min)
[cgc5767]:expression_class_SM
[cgc5767]:expression_class_SMD
[cgc6390]:Cluster_E
Interaction (259)
WBProcessWBbiopr:00000030
WBbiopr:00000046
WBbiopr:00000079
WBbiopr:00000121
Map_infoMapIIPosition0.681931Error0.002224
PositivePositive_cloneC41C4Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Pseudo_map_position
Reference (124)
RemarkSequence connection from [Ron D]. krb 14/11/01
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene