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WormBase Tree Display for WBProcess: WBbiopr:00000079

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Name Class

WBbiopr:00000079Public_nameUnfolded protein response
SummaryThe unfolded protein response (UPR) is a stress response that is critical to maintaining protein homeostasis (proteostasis)- the functional concentration of properly folded protein concentration in an organism. The UPR in entirety involves stress signals in the endoplasmic reticulum the mitochondria and the cytoplasm that are activated by increases in misfolded proteins. The increase in misfolded proteins affect protein concentration and can result in the aggregation of protein species. To restore protein homeostasis, these stress signals up-regulate or down-regulate protein transcription as well as regulate protein translation. These systems also influence protein folding by increasing the concentration of chaperones to aid in the folding process. In addition, these systems can increase the activity of the endoplasmic reticulum-associated degradation (ERAD) pathway, to deal with the increase in misfolded proteins. Eventually, sustained activation of the UPR will lead to cellular apoptosis.
Other_nameUPR
Related_topicGeneralisation_ofWBbiopr:00000046
WBbiopr:00000077
WBbiopr:00000078
Involved_entityGene (38)
MoleculeWBMol:00001482Paper_evidenceWBPaper00031456
WBMol:00002963Paper_evidenceWBPaper00036076
WBMol:00003893Paper_evidenceWBPaper00038075
WBMol:00003950Paper_evidenceWBPaper00035302
WBMol:00004565Paper_evidence (12)
WBMol:00004908Paper_evidenceWBPaper00035154
WBPaper00036076
WBPaper00040692
WBPaper00042074
WBMol:00005329Paper_evidenceWBPaper00032255
WBMol:00005361Paper_evidenceWBPaper00031084
Associated_withGO_termGO:0006986
GO:0005783
GO:0005739
GO:0005829
Reference (87)