WormBase Tree Display for WBProcess: WBbiopr:00000079

WBbiopr:00000079 Public_name: Unfolded protein response
  Summary: The unfolded protein response (UPR) is a stress response that is critical to maintaining protein homeostasis (proteostasis)- the functional concentration of properly folded protein concentration in an organism. The UPR in entirety involves stress signals in the endoplasmic reticulum the mitochondria and the cytoplasm that are activated by increases in misfolded proteins. The increase in misfolded proteins affect protein concentration and can result in the aggregation of protein species. To restore protein homeostasis, these stress signals up-regulate or down-regulate protein transcription as well as regulate protein translation. These systems also influence protein folding by increasing the concentration of chaperones to aid in the folding process. In addition, these systems can increase the activity of the endoplasmic reticulum-associated degradation (ERAD) pathway, to deal with the increase in misfolded proteins. Eventually, sustained activation of the UPR will lead to cellular apoptosis.
  Other_name: UPR
  Related_topic: Generalisation_of: WBbiopr:00000046
      WBbiopr:00000077
      WBbiopr:00000078
  Involved_entity: Gene (38)
    Molecule: WBMol:00001482 Paper_evidence: WBPaper00031456
      WBMol:00002963 Paper_evidence: WBPaper00036076
      WBMol:00003893 Paper_evidence: WBPaper00038075
      WBMol:00003950 Paper_evidence: WBPaper00035302
      WBMol:00004565 Paper_evidence (12)
      WBMol:00004908 Paper_evidence: WBPaper00035154
          WBPaper00036076
          WBPaper00040692
          WBPaper00042074
      WBMol:00005329 Paper_evidence: WBPaper00032255
      WBMol:00005361 Paper_evidence: WBPaper00031084
  Associated_with: GO_term: GO:0006986
      GO:0005783
      GO:0005739
      GO:0005829
  Reference: WBPaper00003967
    WBPaper00004394
    WBPaper00005036
    WBPaper00005044
    WBPaper00005432
    WBPaper00013244
    WBPaper00024210
    WBPaper00024269
    WBPaper00024285
    WBPaper00025202
    WBPaper00026830
    WBPaper00026929
    WBPaper00028479
    WBPaper00030877
    WBPaper00030999
    WBPaper00031084
    WBPaper00031456
    WBPaper00031857
    WBPaper00032003
    WBPaper00032177
    WBPaper00032192
    WBPaper00032255
    WBPaper00032443
    WBPaper00032521
    WBPaper00032977
    WBPaper00033126
    WBPaper00035154
    WBPaper00035294
    WBPaper00035302
    WBPaper00035409
    WBPaper00035580
    WBPaper00036008
    WBPaper00036076
    WBPaper00036115
    WBPaper00037064
    WBPaper00037991
    WBPaper00038075
    WBPaper00038219
    WBPaper00038304
    WBPaper00039930
    WBPaper00039938
    WBPaper00039975
    WBPaper00040397
    WBPaper00040453
    WBPaper00040582
    WBPaper00040692
    WBPaper00040801
    WBPaper00040821
    WBPaper00041022
    WBPaper00041065
    WBPaper00041076
    WBPaper00041159
    WBPaper00041163
    WBPaper00041212
    WBPaper00041269
    WBPaper00041295
    WBPaper00041370
    WBPaper00041512
    WBPaper00041568
    WBPaper00041851
    WBPaper00041954
    WBPaper00041961
    WBPaper00042060
    WBPaper00042074
    WBPaper00042171
    WBPaper00042217
    WBPaper00042524
    WBPaper00044599
    WBPaper00044826
    WBPaper00044925
    WBPaper00045460
    WBPaper00045520
    WBPaper00045553
    WBPaper00045583
    WBPaper00046023
    WBPaper00046303
    WBPaper00046635
    WBPaper00046692
    WBPaper00048983
    WBPaper00049424
    WBPaper00050199
    WBPaper00050442
    WBPaper00051069
    WBPaper00051346
    WBPaper00052950
    WBPaper00053658
    WBPaper00053756