WormBase Tree Display for Feature: WBsf977530
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| WBsf977530 | SMap | S_parent | Sequence | R74 |
|---|---|---|---|---|
| Name | Public_name | IRE-1 binding and splicing site | ||
| Sequence_details | Flanking_sequences | gttgtcgtcgtcggaggagaggatcgccgt | tccacctccatcaacaacaacatcagcaac | |
| Mapping_target | R74 | |||
| DNA_text | gcctttgaatcagcagcattcattaatgagcctcagcagtgggaacaggcccga | |||
| Origin | Species | Caenorhabditis elegans | ||
| Visible | Description | This is the 'IRE-1' binding site for xbp-1 where a 23 bp intron in spliced out. | ||
| SO_term | SO:0000409 | |||
| Defined_by | Defined_by_paper | WBPaper00005036 | ||
| WBPaper00005044 | ||||
| Associations | Associated_with_gene | WBGene00006959 | ||
| Associated_with_Interaction | WBInteraction000521984 | |||
| Bound_by_product_of | WBGene00002147 | |||
| Remark | IRE-1 is a stress-activated endonuclease resident in the ER that is conserved in all known eukaryotes. IRE-1 mediated unconventional splicing of an intron from xbp-1 mRNA controls expression of the encoded transcription factor and is required for upregulation of most UPR target genes. IRE-1 binds to two stem-loop structures in this region of the mRNA that flank the intron that is spliced. [2014-09-03 gw3] | |||
| Method | binding_site |
