WormBase Tree Display for Gene: WBGene00006959
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| WBGene00006959 | SMap | S_parent | Sequence | R74 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | xbp-1 | Person_evidence | WBPerson159 | |||||
| Sequence_name | R74.3 | ||||||||
| Molecular_name | R74.3 | ||||||||
| R74.3.1 | |||||||||
| CE40514 | |||||||||
| R74.3.2 | |||||||||
| Other_name | CELE_R74.3 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | xbp-1 | ||||||||
| DB_info | Database | WormQTL | gene | WBGene00006959 | |||||
| WormFlux | gene | WBGene00006959 | |||||||
| NDB | locus_tag | CELE_R74.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006959|UniProtKB=A0FLQ8 | |||||||
| family | PTHR46542 | ||||||||
| NCBI | gene | 175541 | |||||||
| RefSeq | protein | NM_001083177.4 | |||||||
| SwissProt | UniProtAcc | G5EE07 | |||||||
| UniProt_GCRP | UniProtAcc | G5EE07 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:44 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | xbp | ||||||||
| Allele (18) | |||||||||
| Possibly_affected_by | WBVar02153517 | ||||||||
| WBVar02153518 | |||||||||
| WBVar02153519 | |||||||||
| Strain | WBStrain00034061 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (37) | |||||||||
| Contained_in_operon | CEOP3865 | ||||||||
| Ortholog (25) | |||||||||
| Structured_description | Concise_description | xbp-1 encodes a bZIP transcription factor orthologous to yeast Hac1 and mammalian X box-binding protein 1 (XBP-1, OMIM:194355); XBP-1 is required for the unfolded protein response (UPR) that counteracts cellular stress induced by accumulation of unfolded proteins in the endoplasmic reticulum (ER); xbp-1 mRNA is spliced by the IRE-1 endoribonuclease to promote translation of transcriptionally active XBP-1 that positively regulates UPR gene expression to maintain ER homeostasis and promote normal development; loss of xbp-1 activity also results in near-complete loss of myo-2 pharnygeal myosin expression, although pharyngeal muscle is still present. | Paper_evidence | WBPaper00005036 | |||||
| WBPaper00005044 | |||||||||
| WBPaper00005432 | |||||||||
| WBPaper00012770 | |||||||||
| WBPaper00040399 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 16 Nov 2011 00:00:00 | ||||||||
| Automated_description | Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including defense response to Gram-negative bacterium; determination of adult lifespan; and response to endoplasmic reticulum stress. Predicted to be located in nucleus. Expressed widely. Is an ortholog of human XBP1 (X-box binding protein 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Modifies_disease | DOID:10652 | ||||||||
| Modifies_disease_in_annotation | WBDOannot00000237 | ||||||||
| Molecular_info | Corresponding_CDS | R74.3 | |||||||
| Corresponding_CDS_history | R74.3:wp166 | ||||||||
| R74.3a:wp275 | |||||||||
| R74.3c:wp275 | |||||||||
| Corresponding_transcript | R74.3.1 | ||||||||
| R74.3.2 | |||||||||
| Other_sequence (21) | |||||||||
| Associated_feature (16) | |||||||||
| Gene_product_binds | WBsf019101 | ||||||||
| Transcription_factor | WBTranscriptionFactor000096 | ||||||||
| Experimental_info | RNAi_result (50) | ||||||||
| Expr_pattern | Expr3424 | ||||||||
| Expr4095 | |||||||||
| Expr7648 | |||||||||
| Expr1017530 | |||||||||
| Expr1032970 | |||||||||
| Expr1155684 | |||||||||
| Expr2018089 | |||||||||
| Expr2036227 | |||||||||
| Drives_construct | WBCnstr00011392 | ||||||||
| WBCnstr00012793 | |||||||||
| WBCnstr00034070 | |||||||||
| Construct_product (11) | |||||||||
| Regulate_expr_cluster | WBPaper00005432:xbp-1(zc12)_downregulated | ||||||||
| WBPaper00005432:xbp-1(zc12)_upregulated | |||||||||
| WBPaper00059175:hlh-17p-XBP-1_downregulated | |||||||||
| WBPaper00059175:hlh-17p-XBP-1_upregulated | |||||||||
| Antibody | WBAntibody00001600 | ||||||||
| Microarray_results (30) | |||||||||
| Expression_cluster (170) | |||||||||
| Interaction (117) | |||||||||
| WBProcess | WBbiopr:00000039 | ||||||||
| WBbiopr:00000046 | |||||||||
| WBbiopr:00000050 | |||||||||
| WBbiopr:00000079 | |||||||||
| Map_info | Map | III | Position | -3.69579 | Error | 0.005385 | |||
| Positive | Positive_clone | R74 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 5012 | |||||||
| 4785 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (132) | |||||||||
| Remark | Sequence connection from [Ron D]. krb 14/11/01 | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
