WormBase Tree Display for Gene: WBGene00002147

WBGene00002147 SMap: S_parent: Sequence: C41C4
  Identity: Version: 1
    Name: CGC_name: ire-1 Person_evidence: WBPerson159
      Sequence_name: C41C4.4
      Molecular_name: C41C4.4a
        C41C4.4a.1
        CE35836
        C41C4.4b
        CE45635
        C41C4.4b.1
      Other_name: CELE_C41C4.4 Accession_evidence: NDB BX284602
      Public_name: ire-1
    DB_info: Database (14)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ire
    Allele: WBVar00748265
      WBVar00748266
      WBVar00748267
      WBVar01499702
      WBVar00748268
      WBVar00748269
      WBVar00748270
      WBVar00748271
      WBVar00748272
      WBVar00748273
      WBVar00748274
      WBVar00748275
      WBVar00748276
      WBVar00268847
      WBVar00748277
      WBVar00748278
      WBVar00748279
      WBVar00748280
      WBVar02125079
      WBVar00748281
      WBVar02125080
      WBVar02125081
      WBVar01498435
      WBVar01604242
      WBVar01604243
      WBVar01604244
      WBVar01604245
      WBVar01604246
      WBVar01604247
      WBVar01438702
      WBVar01438703
      WBVar01801876
      WBVar01801877
      WBVar01949197
      WBVar01489999
      WBVar02152399
      WBVar00371505
      WBVar00173896
      WBVar00371506
      WBVar01477690
      WBVar01784143
      WBVar00371507
      WBVar00371508
      WBVar00371509
      WBVar00371510
      WBVar00371511
      WBVar00274962
      WBVar00371512
      WBVar00371513
      WBVar00371514
      WBVar00371515
      WBVar01242039
      WBVar00371516
      WBVar00371517
      WBVar00371518
      WBVar01242043
      WBVar00371519
      WBVar00371520
      WBVar00371521
      WBVar00371522
      WBVar00371523
      WBVar00371524
      WBVar00104618
      WBVar00371525
      WBVar00371526
      WBVar00371527
      WBVar01935042
      WBVar00371528
      WBVar00371529
      WBVar00371530
      WBVar00371531
      WBVar00371532
      WBVar00371533
      WBVar00371534
      WBVar00092079
      WBVar00600941
      WBVar00249448
      WBVar01429591
      WBVar00748210
      WBVar01982552
      WBVar00748211
      WBVar00748212
      WBVar01982553
      WBVar00748213
      WBVar00748214
      WBVar00748215
      WBVar00748216
      WBVar00748217
      WBVar00262729
      WBVar00748218
      WBVar00748219
      WBVar00748220
      WBVar02147511
      WBVar00748221
      WBVar00748222
      WBVar00275456
      WBVar00748223
      WBVar00748224
      WBVar00748225
      WBVar00748226
      WBVar01413661
      WBVar02130330
      WBVar00748227
      WBVar00748228
      WBVar02130331
      WBVar00748229
      WBVar00748230
      WBVar00748231
      WBVar00748232
      WBVar00748233
      WBVar00748234
      WBVar00748235
      WBVar01376190
      WBVar00748236
      WBVar00748237
      WBVar00748238
      WBVar00226089
      WBVar00226090
      WBVar00748239
      WBVar02040240
      WBVar00226091
      WBVar00748240
      WBVar01498940
      WBVar00226092
      WBVar00748241
      WBVar00748242
      WBVar00226093
      WBVar00748243
      WBVar00226094
      WBVar00748244
      WBVar00234656
      WBVar00748245
      WBVar00748246
      WBVar00748247
      WBVar00748248
      WBVar00748249
      WBVar00748250
      WBVar00748251
      WBVar00748252
      WBVar00748253
      WBVar01695728
      WBVar00748254
      WBVar02012152
      WBVar01695729
      WBVar00748255
      WBVar02012153
      WBVar00748256
      WBVar01695730
      WBVar00748257
      WBVar01695731
      WBVar00748258
      WBVar01695732
      WBVar00748259
      WBVar01695733
      WBVar00748260
      WBVar01626908
      WBVar00748261
      WBVar00748262
      WBVar00748263
      WBVar00748264
    Strain: WBStrain00031637
      WBStrain00033316
      WBStrain00034062
    RNASeq_FPKM (74)
    GO_annotation (56)
    Ortholog (54)
    Structured_description: Concise_description: ire-1 encodes a transmembrane serine/threonine protein kinase and site-specific endoribonuclease orthologous to Saccharomyces cerevisiae inositol-requiring 1 protein kinase (Ire1) and human endoplasmic reticulum-to-nucleus signaling 1 (ERN1, OMIM:604033); IRE-1 is required for the unfolded protein response (UPR) that counteracts cellular stress induced by accumulation of unfolded proteins in the endoplasmic reticulum (ER); in response to ER stress, IRE-1 cleaves xbp-1 mRNA to produce transcriptionally active XBP-1 that positively regulates UPR gene expression in order to maintain ER homeostasis. Paper_evidence: WBPaper00005036
            WBPaper00005044
            WBPaper00005432
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables RNA endonuclease activity. Involved in nematode larval development; response to endoplasmic reticulum stress; and response to hypoxia. Acts upstream of with a positive effect on IRE1-mediated unfolded protein response and intrinsic apoptotic signaling pathway by p53 class mediator. Located in neuronal cell body. Expressed widely. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and oropharynx cancer. Is an ortholog of human ERN2 (endoplasmic reticulum to nucleus signaling 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:684 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3449)
      DOID:8557 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3449)
  Molecular_info: Corresponding_CDS: C41C4.4a
      C41C4.4b
    Corresponding_CDS_history: C41C4.4:wp111
    Corresponding_transcript: C41C4.4a.1
      C41C4.4b.1
    Other_sequence (32)
    Associated_feature (18)
    Gene_product_binds: WBsf977530
  Experimental_info: RNAi_result (44)
    Expr_pattern: Expr3423
      Expr1014693
      Expr1031261
      Expr1146268
      Expr2012815
      Expr2031054
    Drives_construct: WBCnstr00011391
      WBCnstr00036417
    Construct_product: WBCnstr00036417
    Microarray_results (21)
    Expression_cluster (119)
    Interaction (259)
    WBProcess: WBbiopr:00000030
      WBbiopr:00000046
      WBbiopr:00000079
      WBbiopr:00000121
  Map_info: Map: II Position: 0.681931 Error: 0.002224
    Positive: Positive_clone: C41C4 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (124)
  Remark: Sequence connection from [Ron D]. krb 14/11/01
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene