WormBase Tree Display for Gene: WBGene00006446
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| WBGene00006446 | SMap | S_parent | Sequence | F28F8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | atx-3 | |||||||
| Sequence_name | F28F8.6 | ||||||||
| Molecular_name | F28F8.6 | ||||||||
| F28F8.6.1 | |||||||||
| CE09760 | |||||||||
| F28F8.6.2 | |||||||||
| F28F8.6.3 | |||||||||
| Other_name | tag-70 | CGC_data_submission | |||||||
| CELE_F28F8.6 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | atx-3 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 04 Nov 2004 16:11:20 | WBPerson2970 | Name_change | CGC_name | atx-3 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | atx | ||||||||
| Allele (60) | |||||||||
| Strain | WBStrain00002998 | ||||||||
| WBStrain00001592 | |||||||||
| WBStrain00026428 | |||||||||
| WBStrain00035696 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (21) | |||||||||
| Contained_in_operon | CEOP5444 | ||||||||
| Ortholog (33) | |||||||||
| Structured_description | Concise_description | atx-3 encodes a deubiquitylating enzyme that is the C. elegans ortholog of human ataxin-3 (ATXN3); atx-3 deletion mutants show no overt phenotype, but loss of atx-3 activity via RNAi has been reported to result in 10-25% embryonic lethality; however, microarray experiments comparing wild-type and atx-3 mutant strains indicate that loss of atx-3 activity results in expression changes in genes involved in the ubiquitin-proteasome pathway, signal transduction, and cell structure and motility; ATX-3 exhibits deubiquitinating (DUB) activity against polyubiquitin chains in vitro; an ATX-3::GFP reporter is expressed throughout the life cycle in a number of different tissues, with adults showing stronger expression than larvae or eggs; ATX-3::GFP localizes to both the nucleus and the cytoplasm, with higher levels found in the cytoplasm. | Paper_evidence | WBPaper00005599 | |||||
| WBPaper00013547 | |||||||||
| WBPaper00029047 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 15 Feb 2011 00:00:00 | ||||||||
| Automated_description | Enables cysteine-type deubiquitinase activity. Involved in chemical synaptic transmission. Located in cytoplasm and nucleus. Expressed in coelomocyte; head; somatic nervous system; and tail neurons. Used to study Machado-Joseph disease. Human ortholog(s) of this gene implicated in Machado-Joseph disease. Is an ortholog of human ATXN3 (ataxin 3) and ATXN3L (ataxin 3 like). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:1440 | Homo sapiens | Paper_evidence | WBPaper00038133 | ||||
| Accession_evidence | OMIM | 109150 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 11 Apr 2013 00:00:00 | ||||||||
| Potential_model | DOID:0060892 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7106) | |||||
| DOID:1440 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7106) | ||||||
| Disease_relevance | Human Ataxin 3 (ATXN3), is a deubiquitinating enzyme and part of the ubiquitin-proteasome system for protein degradation; mutations in ATXN3 are associated with Spinocerebellar ataxia type 3 (SCA3), also called Machado-Joseph disease, which is an autosomal dominant neurodegenerative disease characterized by progressive problems with movement, coordination and balance (ataxia), speech difficulties, uncontrolled muscle tensing (dystonia), and muscle stiffness (spasticity); | Homo sapiens | Accession_evidence | OMIM | 607047 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Models_disease_in_annotation | WBDOannot00000139 | ||||||||
| Molecular_info | Corresponding_CDS | F28F8.6 | |||||||
| Corresponding_transcript | F28F8.6.1 | ||||||||
| F28F8.6.2 | |||||||||
| F28F8.6.3 | |||||||||
| Other_sequence | PPC10479_1 | ||||||||
| JI173670.1 | |||||||||
| CR00590 | |||||||||
| CRC03012_1 | |||||||||
| Associated_feature | WBsf235073 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00077833 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00082468 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00031535 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00094701 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00045852 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00007736 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram20 | ||||||||
| Chronogram2079 | |||||||||
| Expr4767 | |||||||||
| Expr5909 | |||||||||
| Expr5910 | |||||||||
| Expr1019245 | |||||||||
| Expr1032624 | |||||||||
| Expr1149757 | |||||||||
| Expr2009521 | |||||||||
| Expr2027758 | |||||||||
| Drives_construct | WBCnstr00002432 | ||||||||
| WBCnstr00004342 | |||||||||
| WBCnstr00008031 | |||||||||
| WBCnstr00008032 | |||||||||
| WBCnstr00008182 | |||||||||
| WBCnstr00008183 | |||||||||
| WBCnstr00008184 | |||||||||
| WBCnstr00008185 | |||||||||
| Construct_product | WBCnstr00008031 | ||||||||
| WBCnstr00008032 | |||||||||
| WBCnstr00008182 | |||||||||
| WBCnstr00008183 | |||||||||
| WBCnstr00008184 | |||||||||
| WBCnstr00008185 | |||||||||
| Regulate_expr_cluster | WBPaper00029047:atx-3_downregulated | ||||||||
| WBPaper00029047:atx-3_upregulated | |||||||||
| WBPaper00038357:atx-3_regulated_basal | |||||||||
| WBPaper00038357:atx-3_regulated_heat-shock | |||||||||
| Antibody | WBAntibody00001221 | ||||||||
| WBAntibody00002737 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (115) | |||||||||
| Interaction (50) | |||||||||
| Map_info | Map | V | Position | 8.39281 | Error | 0.005185 | |||
| Positive | Positive_clone | F28F8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4929 | |||||||
| Pseudo_map_position | |||||||||
| Reference (14) | |||||||||
| Remark | Gene name created from parsing 'genotype' field from CGC strain information | CGC_data_submission | |||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
