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WormBase Tree Display for Gene: WBGene00000156

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Name Class

WBGene00000156SMapS_parentSequenceK04G2
IdentityVersion1
NameCGC_nameapr-1Person_evidenceWBPerson419
Sequence_nameK04G2.8
Molecular_nameK04G2.8a
K04G2.8a.1
CE06102
K04G2.8b
CE18016
K04G2.8c
CE51809
K04G2.8b.1
K04G2.8c.1
Other_nameAPCPaper_evidenceWBPaper00044307
CELE_K04G2.8Accession_evidenceNDBBX284601
Public_nameapr-1
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:20WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classapr
Allele (69)
Possibly_affected_byWBVar02153202
Legacy_information[Rocheleau CE] apr-1 for APC (adenomatous polyposis coli) Related gene. No mutants known, 26% of apr-1(RNAi) embryos lack endoderm, overproduce pharyngeal tissue, E divides prematurely, adopts MS-like fate. Predicted gene K04G2.8. Allele zh10 isolated, see below. [sdm 12/01]
StrainWBStrain00037280
WBStrain00000140
WBStrain00008585
WBStrain00024309
RNASeq_FPKM (74)
GO_annotation (77)
Ortholog (41)
Structured_descriptionConcise_descriptionThe apr-1 gene encodes an ortholog of human APC (OMIM:175100, mutated in familial adenomatous polyposis) that is required for germline fertility, the control of homeodomain expression (CEH-13 and LIN-39) during embryogenesis and vulval development, and for the migration and elongation of hypodermal cells during embryo morphogenesis; APR-1 is thought to reside in adherens junctions, while also stimulating two beta-catenins in Wnt signalling (HMP-2 in migrating epithelial cells, and BAR-1 in the vulval precursor cells); however, APR-1 also binds PRY-1/axin, and with PRY-1 inhibits RAS-independent Wnt induction of LIN-39; APR-1 along with MOM-5/Frizzled receptor and GSK-3 kinase is also required for the engulfment of apoptotic cells and migration of the distal tip cell in the gonad, indicating that Wnt signaling can regulate cytoskeletal rearrangements via CED-10/RAC; phosphorylated APR-1 binds CED-2/CrkII in yeast two hybrid screens, this binding and genetic studies suggest that APR-1 and MOM-5 activate the CED-2/5/12 branch of the engulfment pathway.Paper_evidence (12)
Curator_confirmedWBPerson324
WBPerson567
Date_last_updated25 May 2011 00:00:00
Automated_descriptionEnables beta-catenin binding activity. Involved in several processes, including embryonic morphogenesis; regulation of Wnt signaling pathway; and regulation of multicellular organismal development. Located in adherens junction; cell cortex; and nucleus. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P8.p hermaphrodite; distal tip cell; and excretory cell. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Sotos syndrome 3; carcinoma (multiple); and gastrointestinal system cancer (multiple). Is an ortholog of human APC (APC regulator of WNT signaling pathway) and APC2 (APC regulator of WNT signaling pathway 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS290 version of WormBase
Date_last_updated11 Sep 2023 00:00:00
Disease_infoPotential_model (21)
Molecular_infoCorresponding_CDSK04G2.8a
K04G2.8b
K04G2.8c
Corresponding_transcriptK04G2.8a.1
K04G2.8b.1
K04G2.8c.1
Other_sequenceAF013950
CGC00612_1
ACC25655_1
EX555243.1
CBC06635_1
Associated_featureWBsf656598
WBsf218114
Experimental_infoRNAi_result (104)
Expr_patternExpr1046
Expr4600
Expr12119
Expr12448
Expr15118
Expr1028112
Expr1030085
Expr1153646
Expr2009365
Expr2027601
Drives_constructWBCnstr00005188
WBCnstr00007256
WBCnstr00009075
WBCnstr00009116
WBCnstr00012108
WBCnstr00016098
WBCnstr00020198
WBCnstr00021087
WBCnstr00037698
Construct_productWBCnstr00000526
WBCnstr00007257
WBCnstr00007258
WBCnstr00009057
WBCnstr00009075
WBCnstr00012108
WBCnstr00016098
WBCnstr00020198
WBCnstr00021087
WBCnstr00037698
AntibodyWBAntibody00000276
WBAntibody00000277
Microarray_results (25)
Expression_cluster (120)
Interaction (179)
WBProcessWBbiopr:00000073
Map_infoMapIPosition2.43771Error0.002342
PositivePositive_cloneK04G2Person_evidenceWBPerson524
Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point4159
4893
5616
Pseudo_map_position
Reference (108)
PictureWBPicture0000013084
RemarkData extracted from Rocheleau et al. (1997)
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene