WormBase Tree Display for Gene: WBGene00003037
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| WBGene00003037 | SMap | S_parent | Sequence | JC8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | lin-54 | Person_evidence | WBPerson261 | |||||
| Sequence_name | JC8.6 | ||||||||
| Molecular_name (12) | |||||||||
| Other_name | CELE_JC8.6 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | lin-54 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 04 Dec 2006 14:39:24 | WBPerson1847 | Event | Acquires_merge | WBGene00010438 | ||||
| Acquires_merge | WBGene00010438 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lin | ||||||||
| Cloned_by | Paper_evidence | WBPaper00028753 | |||||||
| Allele (55) | |||||||||
| Strain | WBStrain00027346 | ||||||||
| WBStrain00027517 | |||||||||
| WBStrain00027524 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (17) | |||||||||
| Contained_in_operon | CEOP4536 | ||||||||
| Ortholog (38) | |||||||||
| Structured_description | Concise_description | lin-54 encode two proteins, LIN-54a and LIN-54b, both of which contain cysteine-rich repeats known as the tesmin/CXC domain, orthologous to lin54 in human T cells (OMIM: 613367); LIN-54 is a DNA binding protein involved in recruiting the DRM complex to its target genes; lin-54 tesmin mutant phenotypes are caused by a defect in DNA binding; LIN-54 targets the DRM complex to genes involved in similar overall biological processes in three different phyla, flies, worms and humans by binding to the proximal promoters of multiple orthologous genes; conserved recruitment of the DRM complex to its target genes by two DNA binding moieties: EFL-1/DPL-1 (E2F/DP) and LIN-54; LIN-54 can activate or repress gene expression; the loss of LIN-54 function causes silencing of X-linked genes; LIN-54 acts with other DRM complex members to govern autosome-enriched binding and chromosome-biased gene regulation; DRM complex formation is sensitive to mutations in lin-54; LIN-54 is broadly expressed in nuclei throughout development. | Paper_evidence | WBPaper00028753 | |||||
| WBPaper00038427 | |||||||||
| Curator_confirmed | WBPerson12884 | ||||||||
| Date_last_updated | 27 Jul 2011 00:00:00 | ||||||||
| Automated_description | Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in autosome and condensed nuclear chromosome. Part of DRM complex. Expressed in several structures, including pharynx and vulva. Is an ortholog of human LIN54 (lin-54 DREAM MuvB core complex component) and TESMIN (testis expressed metallothionein like protein). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | JC8.6a | |||||||
| JC8.6b | |||||||||
| JC8.6c | |||||||||
| JC8.6d | |||||||||
| Corresponding_transcript | JC8.6a.1 | ||||||||
| JC8.6b.1 | |||||||||
| JC8.6c.1 | |||||||||
| JC8.6d.1 | |||||||||
| Other_sequence (50) | |||||||||
| Associated_feature | WBsf229397 | ||||||||
| WBsf229398 | |||||||||
| Experimental_info | RNAi_result (16) | ||||||||
| Expr_pattern | Expr3936 | ||||||||
| Expr4330 | |||||||||
| Expr1014862 | |||||||||
| Expr1031423 | |||||||||
| Expr1153301 | |||||||||
| Expr2013193 | |||||||||
| Expr2031425 | |||||||||
| Drives_construct | WBCnstr00011760 | ||||||||
| WBCnstr00036269 | |||||||||
| Construct_product | WBCnstr00036269 | ||||||||
| Regulate_expr_cluster | WBPaper00038427:lin-54_embryo_changed | ||||||||
| WBPaper00038427:lin-54_germline_changed | |||||||||
| Antibody | WBAntibody00001180 | ||||||||
| WBAntibody00002234 | |||||||||
| Microarray_results (27) | |||||||||
| Expression_cluster (136) | |||||||||
| Interaction (240) | |||||||||
| Map_info | Map | IV | Position | 8.48405 | Error | 0.000804 | |||
| Positive | Positive_clone | JC8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4102 | |||||||
| 4120 | |||||||||
| 4121 | |||||||||
| Reference (34) | |||||||||
| Method | Gene |
