WormBase Tree Display for Gene: WBGene00002015
expand all nodes | collapse all nodes | view schema
| WBGene00002015 | SMap | S_parent | Sequence | T27E4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | hsp-16.1 | Person_evidence | WBPerson36 | |||||
| Sequence_name | T27E4.8 | ||||||||
| Molecular_name | T27E4.8 | ||||||||
| T27E4.8.1 | |||||||||
| CE14249 | |||||||||
| Other_name | hsp-16 | ||||||||
| CELE_T27E4.8 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | hsp-16.1 | ||||||||
| DB_info | Database | AceView | gene | 5J568 | |||||
| WormQTL | gene | WBGene00002015 | |||||||
| WormFlux | gene | WBGene00002015 | |||||||
| NDB | locus_tag | CELE_T27E4.8 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00002015|UniProtKB=P34696 | |||||||
| family | PTHR45640 | ||||||||
| NCBI | gene | 179286 | |||||||
| RefSeq | protein | NM_072953.5 | |||||||
| SwissProt | UniProtAcc | P34696 | |||||||
| UniProt_GCRP | UniProtAcc | P34696 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | hsp | ||||||||
| Allele | WBVar01499903 | ||||||||
| WBVar01500129 | |||||||||
| WBVar00091863 | |||||||||
| WBVar01499419 | |||||||||
| WBVar01499420 | |||||||||
| WBVar01499056 | |||||||||
| WBVar01499249 | |||||||||
| WBVar01499316 | |||||||||
| Strain | WBStrain00004819 | ||||||||
| WBStrain00004820 | |||||||||
| WBStrain00030548 | |||||||||
| WBStrain00030720 | |||||||||
| WBStrain00030838 | |||||||||
| In_cluster | HSP16A | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00044149 | ||||||||
| 00044150 | |||||||||
| 00044151 | |||||||||
| 00044152 | |||||||||
| 00044153 | |||||||||
| 00044154 | |||||||||
| 00105765 | |||||||||
| 00105800 | |||||||||
| 00106135 | |||||||||
| 00106136 | |||||||||
| Ortholog (91) | |||||||||
| Paralog (17) | |||||||||
| Structured_description | Concise_description | hsp-16.1 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins, and that is identical to the protein encoded by hsp-16.11; an hsp-16.1 reporter fusion, expressed broadly but most strongly in muscle and hypodermis, is induced solely in response to heat shock or other environmental stresses; expression is detectable in somatic tissues in post-gastrulation embryos, all larval stages, and in adults; HSP-16.1 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating. | Paper_evidence | WBPaper00001187 | |||||
| WBPaper00001497 | |||||||||
| WBPaper00002665 | |||||||||
| WBPaper00004424 | |||||||||
| WBPaper00013029 | |||||||||
| WBPaper00013239 | |||||||||
| WBPaper00013280 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 05 Nov 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable unfolded protein binding activity. Involved in defense response to Gram-negative bacterium and response to heat. Located in Golgi medial cisterna. Expressed in several structures, including coelomocyte; enteric muscle; intestine; pharynx; and ventral nerve cord. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Disease_relevance | C. elegans is an effective model system to study heat-related pathologies like heat stroke; in elegans, a small heat shock protein (sHSP), HSP-16.1 has a protective effect against heat-induced necrosis; HSP-16.1 localizes to the golgi and functions together with the PMR-1/PMR1 Ca2+ and Mn2+ transporting ATPase, and NUCB-1/Nucleobindin1, a golgi-located calcium-buffering protein, to maintain calcium homeostasis, under heat stroke; overexpresiion of pmr-1/PMR1 is sufficient to promote survival after heat stroke, bypassing both HSF-1 and HSP-16.1, indicating that PMR-1/PMR1 functions downstream of both these genes. | Homo sapiens | Paper_evidence | WBPaper00041564 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 29 May 2013 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | T27E4.8 | |||||||
| Corresponding_transcript | T27E4.8.1 | ||||||||
| Other_sequence (60) | |||||||||
| Associated_feature | WBsf977958 | Paper_evidence | WBPaper00000918 | ||||||
| WBsf977959 | Paper_evidence | WBPaper00000918 | |||||||
| WBsf977962 | |||||||||
| WBsf1000813 | |||||||||
| WBsf234177 | |||||||||
| WBsf234178 | |||||||||
| Experimental_info | RNAi_result (21) | ||||||||
| Expr_pattern | Expr1381 | ||||||||
| Expr1384 | |||||||||
| Expr10597 | |||||||||
| Expr11025 | |||||||||
| Expr15516 | |||||||||
| Expr1157862 | |||||||||
| Expr2012617 | |||||||||
| Expr2030853 | |||||||||
| Drives_construct (37) | |||||||||
| Construct_product | WBCnstr00010254 | ||||||||
| WBCnstr00017024 | |||||||||
| WBCnstr00019264 | |||||||||
| WBCnstr00036521 | |||||||||
| WBCnstr00042207 | |||||||||
| Antibody | WBAntibody00000049 | ||||||||
| WBAntibody00001859 | |||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (245) | |||||||||
| Interaction (92) | |||||||||
| WBProcess | WBbiopr:00000050 | ||||||||
| Map_info | Map | V | Position | 1.9236 | Error | 0.000891 | |||
| Positive | Positive_clone | T27E4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4419 | |||||||
| 5342 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (121) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
