WormBase Tree Display for Gene: WBGene00006733
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| WBGene00006733 | SMap | S_parent | Sequence | F19B6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | ufd-1 | Person_evidence | WBPerson50 | |||||
| WBPerson2333 | |||||||||
| Sequence_name | F19B6.2 | ||||||||
| Molecular_name | F19B6.2a | ||||||||
| F19B6.2a.1 | |||||||||
| CE05667 | |||||||||
| F19B6.2b | |||||||||
| CE23674 | |||||||||
| F19B6.2b.1 | |||||||||
| Other_name | CELE_F19B6.2 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | ufd-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ufd | ||||||||
| Allele (27) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Contained_in_operon | CEOP4512 | ||||||||
| Ortholog (40) | |||||||||
| Structured_description | Concise_description | ufd-1 encodes the C. elegans ortholog of Saccharomyces cerevisiae Ufd1p, a protein that is part of the Cdc48/Ufd1/Npl4 complex that mediates endoplasmic reticulum (ER)-associated protein degradation; loss of ufd-1 function via RNAi results in increased sensitivity to ER stress indicating that, like its yeast ortholog, ufd-1 plays a role in ER-associated protein degradation; ufd-1 is also essential for embryonic development and for efficient DNA replication during cell cycle progression; UFD-1 interacts with both CDC-48.1 and CDC-48.2 as well as NPL-4.2 in yeast two-hybrid assays, suggesting that an analogous CDC-48/UFD1/NPL4 complex, predicted to localize to the endoplasmic reticulum, exists in C. elegans; a YFP::UFD-1 reporter has also been shown to localize to the nucleus. | Paper_evidence | WBPaper00027357 | |||||
| WBPaper00032125 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 15 Jul 2010 00:00:00 | ||||||||
| Automated_description | Predicted to enable polyubiquitin modification-dependent protein binding activity. Involved in ER-associated misfolded protein catabolic process; embryo development; and positive regulation of protein localization to nucleus. Located in nucleus. Part of VCP-NPL4-UFD1 AAA ATPase complex. Used to study velocardiofacial syndrome. Human ortholog(s) of this gene implicated in DiGeorge syndrome and schizophrenia. Is an ortholog of human UFD1 (ubiquitin recognition factor in ER associated degradation 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:12583 | Homo sapiens | Paper_evidence | WBPaper00047004 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 13 Sep 2017 00:00:00 | ||||||||
| Potential_model | DOID:11198 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12520) | |||||
| DOID:5419 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12520) | ||||||
| Disease_relevance | 22q11.2 deletion syndrome (22q11.2DS) is the most common human deletion syndrome caused by deletion of a small piece of chromosome 22, characterized by neurodevelopmental defects, schizophrenia, congenital cardiac and craniofacial abnormalites (includes DiGeorge Syndrome and velocardiofacial syndrome); the 22q11.2 deletion overlaps several protein-coding genes including UFD1L (ubiquitin fusion degradation 1 like (yeast)); C. elegans ufd-1 is involved in ER-associated protein degradation and DNA replication and knock-down phenotypes include slow growth, defects in gonad development and locomotion, enlarged gut granules, cell cycle progression defects and reduced life span; ufd-1 provides a potential model system to study genes involved in 22q11.2DS. | Homo sapiens | Paper_evidence | WBPaper00047004 | |||||
| WBPaper00032135 | |||||||||
| Accession_evidence | OMIM | 611867 | |||||||
| 601754 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 16 Sep 2015 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000367 | ||||||||
| Molecular_info | Corresponding_CDS | F19B6.2a | |||||||
| F19B6.2b | |||||||||
| Corresponding_transcript | F19B6.2a.1 | ||||||||
| F19B6.2b.1 | |||||||||
| Other_sequence (57) | |||||||||
| Associated_feature | WBsf652288 | ||||||||
| WBsf668415 | |||||||||
| WBsf977009 | |||||||||
| WBsf230999 | |||||||||
| Experimental_info | RNAi_result (31) | ||||||||
| Expr_pattern | Expr8954 | ||||||||
| Expr1017281 | |||||||||
| Expr1032808 | |||||||||
| Expr1148964 | |||||||||
| Expr2017747 | |||||||||
| Expr2035886 | |||||||||
| Drives_construct | WBCnstr00034187 | ||||||||
| Construct_product | WBCnstr00006164 | ||||||||
| WBCnstr00034187 | |||||||||
| Antibody | WBAntibody00002589 | ||||||||
| Microarray_results (30) | |||||||||
| Expression_cluster (90) | |||||||||
| Interaction (93) | |||||||||
| WBProcess | WBbiopr:00000076 | ||||||||
| Map_info | Map | IV | Position | 5.85046 | Error | 0.001284 | |||
| Positive | Positive_clone | F19B6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (14) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
