WormBase Tree Display for Gene: WBGene00000121
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| WBGene00000121 | SMap | S_parent | Sequence | F23B2 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | aly-2 | Person_evidence | WBPerson297 | |||||
| WBPerson4981 | |||||||||
| Sequence_name | F23B2.6 | ||||||||
| Molecular_name | F23B2.6 | ||||||||
| F23B2.6.1 | |||||||||
| CE09586 | |||||||||
| Other_name | ref-2 | Paper_evidence | WBPaper00013477 | ||||||
| CELE_F23B2.6 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | aly-2 | ||||||||
| DB_info | Database | AceView | gene | 4J913 | |||||
| WormQTL | gene | WBGene00000121 | |||||||
| WormFlux | gene | WBGene00000121 | |||||||
| NDB | locus_tag | CELE_F23B2.6 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000121|UniProtKB=O62183 | |||||||
| family | PTHR19965 | ||||||||
| NCBI | gene | 177738 | |||||||
| RefSeq | protein | NM_069193.7 | |||||||
| TREEFAM | TREEFAM_ID | TF313312 | |||||||
| TrEMBL | UniProtAcc | O62183 | |||||||
| UniProt_GCRP | UniProtAcc | O62183 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 27 Apr 2005 13:39:18 | WBPerson2970 | Name_change | Other_name | ref-2 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | aly | ||||||||
| Allele (28) | |||||||||
| Strain | WBStrain00031866 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00037249 | ||||||||
| 00037250 | |||||||||
| 00037251 | |||||||||
| 00037252 | |||||||||
| 00106835 | |||||||||
| Ortholog (51) | |||||||||
| Paralog | WBGene00000120 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00000122 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00015329 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | aly-2 encodes an RRM motif-containing protein required for normal export of TRA-1/tra-2 mRNA complexes, and thus for normal hermaphroditism; ALY-2 is orthologous to human THOC4 (OMIM:604171), and paralogous to ALY-1 and ALY-3; in the absence of TRA-1, and in conjunction with NXF-1, ALY-2 and its paralog ALY-1 are required to bind the TRE 3' UTR element of tra-2 mRNA, and block tra-2 mRNA's export from the nucleus; aly-2(RNAi) animals have abnormal female (as opposed to hermaphrodite) sexual phenotypes; by orthology, ALY-2 is thought to promote recruitment of mRNA export factor to mRNAs; other than these sex-determination phenotypes, ALY-2 has no grossly obvious function in four-way RNAi assays of ALY-1/-3 and W04D2.6. | Paper_evidence | WBPaper00013477 | |||||
| WBPaper00030790 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 09 Dec 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable mRNA binding activity. Predicted to be involved in mRNA export from nucleus. Predicted to be located in nucleus. Is an ortholog of human ALYREF (Aly/REF export factor). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F23B2.6 | |||||||
| Corresponding_transcript | F23B2.6.1 | ||||||||
| Other_sequence | CGC01173_1 | ||||||||
| CJC05522_1 | |||||||||
| CR01957 | |||||||||
| CBC10390_1 | |||||||||
| CRC02984_1 | |||||||||
| CBC00520_1 | |||||||||
| CRC09193_1 | |||||||||
| Associated_feature | WBsf646218 | ||||||||
| WBsf228792 | |||||||||
| Gene_product_binds (11001) | |||||||||
| Transcription_factor | WBTranscriptionFactor000754 | ||||||||
| Experimental_info | RNAi_result (18) | ||||||||
| Expr_pattern | Expr13879 | ||||||||
| Expr1028128 | |||||||||
| Expr1030067 | |||||||||
| Expr1149316 | |||||||||
| Expr1200068 | |||||||||
| Expr2009317 | |||||||||
| Expr2027553 | |||||||||
| Drives_construct | WBCnstr00037717 | ||||||||
| Construct_product | WBCnstr00017321 | ||||||||
| WBCnstr00037717 | |||||||||
| WBCnstr00040227 | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (169) | |||||||||
| Interaction (116) | |||||||||
| Map_info | Map | IV | Position | 4.08336 | Error | 0.004606 | |||
| Positive | Positive_clone | F23B2 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4892 | |||||||
| 4754 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (20) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Published as ref-2. The CGC approved ref-2 is a different sequence with ID WBGene00004335 | Paper_evidence | WBPaper00013477 | |||||||
| Method | Gene |
