WormBase Tree Display for Gene: WBGene00000120
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| WBGene00000120 | SMap | S_parent | Sequence | C01F6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | aly-1 | Person_evidence | WBPerson297 | |||||
| WBPerson4981 | |||||||||
| Sequence_name | C01F6.5 | ||||||||
| Molecular_name | C01F6.5 | ||||||||
| C01F6.5.1 | |||||||||
| CE02954 | |||||||||
| Other_name | ref-1 | Paper_evidence | WBPaper00013477 | ||||||
| CELE_C01F6.5 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | aly-1 | ||||||||
| DB_info | Database | AceView | gene | 4J873 | |||||
| WormQTL | gene | WBGene00000120 | |||||||
| WormFlux | gene | WBGene00000120 | |||||||
| NDB | locus_tag | CELE_C01F6.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000120|UniProtKB=Q17561 | |||||||
| family | PTHR19965 | ||||||||
| NCBI | gene | 177735 | |||||||
| RefSeq | protein | NM_069187.8 | |||||||
| TREEFAM | TREEFAM_ID | TF313312 | |||||||
| TrEMBL | UniProtAcc | Q17561 | |||||||
| UniProt_GCRP | UniProtAcc | Q17561 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 27 Apr 2005 13:40:18 | WBPerson2970 | Name_change | Other_name | ref-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | aly | ||||||||
| Allele (20) | |||||||||
| Strain | WBStrain00032271 | ||||||||
| WBStrain00037646 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00058513 | ||||||||
| 00058514 | |||||||||
| 00058515 | |||||||||
| 00058516 | |||||||||
| 00106834 | |||||||||
| Ortholog (59) | |||||||||
| Paralog | WBGene00000121 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00000122 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00015329 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | aly-1 encodes an RRM motif-containing protein required for normal export of TRA-1/tra-2 mRNA complexes, and thus for normal hermaphroditism; ALY-1 is orthologous to human THOC4 (OMIM:604171), and paralogous to ALY-2 and ALY-3; in the absence of TRA-1, and in conjunction with NXF-2, ALY-1 and its paralog ALY-2 are required to bind the TRE 3' UTR element of tra-2 mRNA, and block tra-2 mRNA's export from the nucleus; ALY-1 and NXF-2 bind the TRE element in vitro; ALY-1 is also bound competitively by either NXF-2 or TRA-1 in vitro; aly-1(RNAi) animals have abnormal female (as opposed to hermaphrodite) sexual phenotypes; by orthology, ALY-1 is thought to promote recruitment of mRNA export factor to mRNAs. | Paper_evidence | WBPaper00013477 | |||||
| WBPaper00030790 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 24 Jul 2012 00:00:00 | ||||||||
| Automated_description | Predicted to enable mRNA binding activity. Predicted to be involved in mRNA export from nucleus. Predicted to be located in nucleus. Is an ortholog of human ALYREF (Aly/REF export factor). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C01F6.5 | |||||||
| Corresponding_transcript | C01F6.5.1 | ||||||||
| Other_sequence | CBC17281_1 | ||||||||
| Associated_feature | WBsf646214 | ||||||||
| WBsf655036 | |||||||||
| WBsf997356 | |||||||||
| WBsf997357 | |||||||||
| WBsf1017926 | |||||||||
| WBsf1017927 | |||||||||
| WBsf228787 | |||||||||
| Experimental_info | RNAi_result (15) | ||||||||
| Expr_pattern | Expr13878 | ||||||||
| Expr1022895 | |||||||||
| Expr1030066 | |||||||||
| Expr1143427 | |||||||||
| Expr2009316 | |||||||||
| Expr2027552 | |||||||||
| Drives_construct | WBCnstr00017948 | ||||||||
| Construct_product | WBCnstr00016846 | ||||||||
| WBCnstr00017948 | |||||||||
| WBCnstr00040226 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (173) | |||||||||
| Interaction (221) | |||||||||
| Map_info | Map | IV | Position | 4.05043 | Error | 0.00037 | |||
| Positive | Positive_clone | C01F6 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (25) | |||||||||
| Remark | Published as ref-1. The CGC approved ref-1 is a different sequence with ID WBGene00004334 | Paper_evidence | WBPaper00013477 | ||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
