WormBase Tree Display for Gene: WBGene00006474
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| WBGene00006474 | SMap | S_parent | Sequence | C14B1 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 5 | |||||||
| Name | CGC_name | wdr-5.1 | Paper_evidence | WBPaper00032309 | |||||
| Person_evidence | WBPerson467 | ||||||||
| Sequence_name | C14B1.4 | ||||||||
| Molecular_name | C14B1.4 | ||||||||
| C14B1.4.1 | |||||||||
| CE00901 | |||||||||
| Other_name | swd-3.1 | Paper_evidence | WBPaper00032309 | ||||||
| swd-3 | |||||||||
| tag-125 | |||||||||
| wdr-5 | Paper_evidence | WBPaper00036383 | |||||||
| CELE_C14B1.4 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | wdr-5.1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 29 Jun 2006 14:27:02 | WBPerson2970 | Event | Acquires_merge | WBGene00007575 | ||||
| 3 | 01 Sep 2009 13:39:27 | WBPerson9133 | Name_change | CGC_name | swd-3.1 | ||||
| 4 | 27 Jul 2010 11:17:32 | WBPerson2970 | Name_change | CGC_name | wdr-5 | ||||
| Other_name | wdr-5.1 | ||||||||
| 5 | 02 Dec 2010 14:00:12 | WBPerson2970 | Name_change | CGC_name | wdr-5.1 | ||||
| Other_name | wdr-5 | ||||||||
| Acquires_merge | WBGene00007575 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | wdr | ||||||||
| Allele (29) | |||||||||
| Strain | WBStrain00032003 | ||||||||
| WBStrain00000041 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Contained_in_operon | CEOP3136 | ||||||||
| Ortholog (42) | |||||||||
| Paralog | WBGene00010572 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| WormBase-Compara | |||||||||
| WBGene00013862 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| WormBase-Compara | |||||||||
| WBGene00012858 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00003047 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00004314 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00008586 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00015974 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00019237 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | wdr-5.1 encodes a WD40 repeat-containing protein that is the C. elegans ortholog of mammalian WDR5, a member of a conserved H3K4 trimethylation (H3K4me3) complex; WDR-5.1 functions to regulate H3K4 methylation levels and to negatively regulate adult worm lifespan; WDR-5.1 activity also antagonizes SynMuv transcriptional repressors; WDR-5.1 is broadly expressed beginning at the 20-cell stage of embryogenesis with continuing expression seen, albeit more restricted, through adulthood; WDR-5.1 localizes to the nucleus. | Paper_evidence | WBPaper00027634 | |||||
| WBPaper00032309 | |||||||||
| WBPaper00035979 | |||||||||
| WBPaper00036383 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 02 Dec 2010 00:00:00 | ||||||||
| Automated_description | Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in determination of adult lifespan; programmed cell death; and transdifferentiation. Located in cytoplasm and nucleus. Part of MLL3/4 complex. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; hermaphrodite gonad; neurons; and somatic gonad precursor. Is an ortholog of human WDR5 (WD repeat domain 5). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C14B1.4 | |||||||
| Corresponding_transcript | C14B1.4.1 | ||||||||
| Other_sequence (32) | |||||||||
| Associated_feature | WBsf645041 | ||||||||
| WBsf981439 | |||||||||
| WBsf224640 | |||||||||
| WBsf224641 | |||||||||
| WBsf224642 | |||||||||
| Experimental_info | RNAi_result (18) | ||||||||
| Expr_pattern | Expr8345 | ||||||||
| Expr11955 | |||||||||
| Expr1019800 | |||||||||
| Expr1032643 | |||||||||
| Expr1144560 | |||||||||
| Expr2018057 | |||||||||
| Expr2036194 | |||||||||
| Drives_construct | WBCnstr00013269 | ||||||||
| WBCnstr00037899 | |||||||||
| Construct_product | WBCnstr00013269 | ||||||||
| WBCnstr00037899 | |||||||||
| Regulate_expr_cluster | WBPaper00045861:wdr-5(ok1417)_downregulated | ||||||||
| WBPaper00045861:wdr-5(ok1417)_upregulated | |||||||||
| WBPaper00058691:WDR-5.1_interacting_protein | |||||||||
| WBPaper00058711:wdr-5(ok1417)_downregulated | |||||||||
| WBPaper00058711:wdr-5(ok1417)_upregulated | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (118) | |||||||||
| Interaction (400) | |||||||||
| Map_info | Map | III | Position | -4.52761 | Error | 0.040627 | |||
| Positive | Positive_clone | C14B1 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (31) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
