WormBase Tree Display for Gene: WBGene00006474

expand all nodes | collapse all nodes | view schema

WBGene00006474	SMap	S_parent	Sequence	C14B1
	Identity	Version	5
		Name	CGC_name	wdr-5.1	Paper_evidence	WBPaper00032309
					Person_evidence	WBPerson467
			Sequence_name	C14B1.4
			Molecular_name	C14B1.4
				C14B1.4.1
				CE00901
			Other_name	swd-3.1	Paper_evidence	WBPaper00032309
				swd-3
				tag-125
				wdr-5	Paper_evidence	WBPaper00036383
				CELE_C14B1.4	Accession_evidence	NDB	BX284603
			Public_name	wdr-5.1
		DB_info	Database (11)
		Species	Caenorhabditis elegans
		History	Version_change	1	07 Apr 2004 11:29:40	WBPerson1971	Event	Imported	Initial conversion from geneace
				2	29 Jun 2006 14:27:02	WBPerson2970	Event	Acquires_merge	WBGene00007575
				3	01 Sep 2009 13:39:27	WBPerson9133	Name_change	CGC_name	swd-3.1
				4	27 Jul 2010 11:17:32	WBPerson2970	Name_change	CGC_name	wdr-5
								Other_name	wdr-5.1
				5	02 Dec 2010 14:00:12	WBPerson2970	Name_change	CGC_name	wdr-5.1
								Other_name	wdr-5
			Acquires_merge	WBGene00007575
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	wdr
		Allele (29)
		Strain	WBStrain00032003
			WBStrain00000041
		RNASeq_FPKM (74)
		GO_annotation (19)
		Contained_in_operon	CEOP3136
		Ortholog (42)
		Paralog	WBGene00010572	Caenorhabditis elegans	From_analysis	TreeFam
						WormBase-Compara
			WBGene00013862	Caenorhabditis elegans	From_analysis	TreeFam
						WormBase-Compara
			WBGene00012858	Caenorhabditis elegans	From_analysis	Panther
			WBGene00003047	Caenorhabditis elegans	From_analysis	WormBase-Compara
			WBGene00004314	Caenorhabditis elegans	From_analysis	WormBase-Compara
			WBGene00008586	Caenorhabditis elegans	From_analysis	WormBase-Compara
			WBGene00015974	Caenorhabditis elegans	From_analysis	WormBase-Compara
			WBGene00019237	Caenorhabditis elegans	From_analysis	WormBase-Compara
		Structured_description	Concise_description	wdr-5.1 encodes a WD40 repeat-containing protein that is the C. elegans ortholog of mammalian WDR5, a member of a conserved H3K4 trimethylation (H3K4me3) complex; WDR-5.1 functions to regulate H3K4 methylation levels and to negatively regulate adult worm lifespan; WDR-5.1 activity also antagonizes SynMuv transcriptional repressors; WDR-5.1 is broadly expressed beginning at the 20-cell stage of embryogenesis with continuing expression seen, albeit more restricted, through adulthood; WDR-5.1 localizes to the nucleus.	Paper_evidence	WBPaper00027634
						WBPaper00032309
						WBPaper00035979
						WBPaper00036383
					Curator_confirmed	WBPerson1843
						WBPerson567
					Date_last_updated	02 Dec 2010 00:00:00
			Automated_description	Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in determination of adult lifespan; programmed cell death; and transdifferentiation. Located in cytoplasm and nucleus. Part of MLL3/4 complex. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; hermaphrodite gonad; neurons; and somatic gonad precursor. Is an ortholog of human WDR5 (WD repeat domain 5).	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Molecular_info	Corresponding_CDS	C14B1.4
		Corresponding_transcript	C14B1.4.1
		Other_sequence (32)
		Associated_feature	WBsf645041
			WBsf981439
			WBsf224640
			WBsf224641
			WBsf224642
	Experimental_info	RNAi_result (18)
		Expr_pattern	Expr8345
			Expr11955
			Expr1019800
			Expr1032643
			Expr1144560
			Expr2018057
			Expr2036194
		Drives_construct	WBCnstr00013269
			WBCnstr00037899
		Construct_product	WBCnstr00013269
			WBCnstr00037899
		Regulate_expr_cluster	WBPaper00045861:wdr-5(ok1417)_downregulated
			WBPaper00045861:wdr-5(ok1417)_upregulated
			WBPaper00058691:WDR-5.1_interacting_protein
			WBPaper00058711:wdr-5(ok1417)_downregulated
			WBPaper00058711:wdr-5(ok1417)_upregulated
		Microarray_results (19)
		Expression_cluster	WBPaper00031040:TGF-beta_adult_downregulated
			WBPaper00033065:cyc-1(RNAi)_downregulated
			WBPaper00036375:enriched_in_PVD_OLL
			WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
			WBPaper00037950:all-neurons_L2-larva_expressed
			WBPaper00037950:BAG-neuron_blastula-embryo_expressed
			WBPaper00037950:bodywall-muscle_L2-larva_expressed
			WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
			WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
			WBPaper00037950:excretory-cell_L2-larva_expressed
			WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
			WBPaper00037950:germline-precursors_blastula-embryo_expressed
			WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
			WBPaper00037950:hypodermis_L3-L4-larva_expressed
			WBPaper00037950:intestine_L2-larva_expressed
			WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
			WBPaper00038289:oocyte_protein
			WBPaper00040134:nhr-49(RNAi)_regulated_protein
			WBPaper00040209:B.thuringiensis_upregulated_MY15
			WBPaper00040221:DAF-12_target_ALF4
			WBPaper00041071:spe-44_upregulated
			WBPaper00041072:UTX-1_interacting_protein
			WBPaper00044128:DietaryRestriction_upregulated
			WBPaper00044656:tatn-1(qd182)_downregulated
			WBPaper00044736:flat_dev_expression
			WBPaper00044760:germline_specific
			WBPaper00045521:Oogenic
			WBPaper00045729:gld-2(RNAi)_downregulated
			WBPaper00045861:wdr-5(ok1417)_downregulated
			WBPaper00045974:NSM_enriched_DSN-treated_RNAseq
			WBPaper00045974:NSM_enriched_totalRNA_RNAseq
			WBPaper00048988:neuron_expressed
			WBPaper00049018:SWSN-2.2_interacting
			WBPaper00049498:npr-1(ur89)_regulated_6
			WBPaper00049942:hsf-1(RNAi)_upregulated
			WBPaper00050488:adult_vs_dauer_regulated_N2_20C
			WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
			WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
			WBPaper00050990:body-muscle_expressed
			WBPaper00050990:GABAergic-neuron_expressed
			WBPaper00050990:hypodermis_expressed
			WBPaper00050990:intestine_expressed
			WBPaper00051039:germline_enriched
			WBPaper00052884:emb-4(hc60)_downregulated
			WBPaper00053184:sma-4(rax3)_downregulated
			WBPaper00053302:stavudine_24h_regulated
			WBPaper00053302:zidovudine_72h_regulated
			WBPaper00053615:SMO-1_target
			WBPaper00053810:daf-2(e1370)_downregulated
			WBPaper00053810:nuo-6(qm200)_downregulated
			WBPaper00055648:germline_expressed
			WBPaper00055971:nhl-2(ok818)_25C_upregulated
			WBPaper00056034:pals-22(jy3)_downregulated
			WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
			WBPaper00056284:ints-5(RNAi)_downregulated
			WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
			WBPaper00057288:Cold_upregulated_transcript
			WBPaper00058691:cfp-1(tm6369)_upregulated
			WBPaper00058691:CFP-1_interacting_protein
			WBPaper00058691:WDR-5.1_interacting_protein
			WBPaper00058711:wdr-5(ok1417)_downregulated
			WBPaper00059567:olrn-1(ums9)_regulated
			WBPaper00059763:neuron_expressed
			WBPaper00060014:set-2(tm1630)_upregulated
			WBPaper00060459:bcat-1(RNAi)_downregulated
			WBPaper00060683:hlh-11(ko1)_downregulated
			WBPaper00060811:L1_vs_adult_upregulated_neural
			WBPaper00061007:HB101_downregulated
			WBPaper00061007:S.aquatilis_downregulated
			WBPaper00061274:hypergravity_15xg_upregulated
			WBPaper00061479:HDA-1_interacting_protein
			WBPaper00061527:pcn-1-cyb-3_17196
			WBPaper00061902:camt-1(ok515)_regulated_RMG
			WBPaper00062159:hda-2(ok1479)_downregulated
			WBPaper00062456:doxycycline_downregulated_CB4856_protein
			WBPaper00062498:PPM-1.D_interacting
			WBPaper00064071:NHR-49_interacting
			WBPaper00064130:Beta-Amyloid_downregulated_protein
			WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated
			WBPaper00064716:paraquat_upregulated
			WBPaper00065096:25C_vs_20C_upregulated
			WBPaper00065096:Day10_vs_Day1_upregulated
			WBPaper00065158:25C_vs_15C_upregulated_AFD
			WBPaper00065373:Cisplatin_downregulated_WT
			WBPaper00065373:sek-1(km4)_upregulated_cisplatin
			WBPaper00065975:P-body_vs_oocyte_enriched
			WBPaper00065975:P-body_vs_WholeAnimal_enriched
			WBPaper00065993:glp-1(e2141)_downregulated
			WBPaper00066110:tetraploid_vs_diploid_downregulated
			WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
			cgc4489_group_2
			WBPaper00025032:cluster_65
			WBPaper00025141:N2_Expressed_Genes
			WBPaper00025141:unc-4::GFP_Expressed_Genes
			WBPaper00026929:sir-2.1_overexpression_regulated
			WBPaper00032165:differentially_expressed_with_age_medoid_3
			WBPaper00034739:N2moreDR1350
			WBPaper00034757:down_by_oxidative_stress
			WBPaper00035905:FBF-1_Associated
			WBPaper00036130:mir-243_down_regulated
			WBPaper00036286:Pattern_F
			WBPaper00037147:heatshock_upregulated
			WBPaper00037611:GLD-2-associated
			WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
			WBPaper00040963:TA300_down
			WBPaper00041002:HF_3d_2.0mM_Down
			WBPaper00041606:CE_B.thuringiensis-DB27_regulated
			WBPaper00041606:CE_S.marcescens_regulated
			WBPaper00041606:CE_X.nematophila_regulated
			WBPaper00045263:0.1mM-paraquat_upregulated
			WBPaper00048624:hlh-25(ok1710)_upregulated
			WBPaper00048989:N2_rapamycin_downregulated
			WBPaper00053236:Starvation_regulated_GR1307
			WBPaper00053236:Starvation_regulated_N2
			[cgc5767]:expression_class_M
			[cgc5767]:expression_class_SM
			[cgc6390]:Cluster_E
			[cgc6390]:oogenesis-enriched
		Interaction (400)
	Map_info	Map	III	Position	-4.52761	Error	0.040627
		Positive	Positive_clone	C14B1	Inferred_automatically	From sequence, transcript, pseudogene data
		Pseudo_map_position
	Reference (31)
	Remark	Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.	CGC_data_submission
	Method	Gene