WormBase Tree Display for Gene: WBGene00006311
expand all nodes | collapse all nodes | view schema
| WBGene00006311 | Evidence | Person_evidence | WBPerson1240 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| WBPerson689 | |||||||||
| SMap | S_parent | Sequence | F57B1 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | sun-1 | Person_evidence | WBPerson689 | |||||
| Sequence_name | F57B1.2 | ||||||||
| Molecular_name | F57B1.2 | ||||||||
| F57B1.2.1 | |||||||||
| CE11288 | |||||||||
| Other_name | mtf-1 | CGC_data_submission | |||||||
| CELE_F57B1.2 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | sun-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | sun | ||||||||
| Allele (34) | |||||||||
| Strain | WBStrain00029178 | ||||||||
| WBStrain00029186 | |||||||||
| WBStrain00031976 | |||||||||
| WBStrain00035459 | |||||||||
| WBStrain00035653 | |||||||||
| WBStrain00004072 | |||||||||
| WBStrain00047219 | |||||||||
| Component_of_genotype | WBGenotype00000136 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (15) | |||||||||
| Ortholog (223) | |||||||||
| Paralog | WBGene00006816 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | sun-1 encodes a protein member of the SUN-domain family, also called Matefin and is paralogous to UNC-84, whose general domain organization (one or more central transmembrane and coiled-coil domains, followed by a C-terminal SUN domain) is shared by Sad1p from Schizosaccharomyces pombe and UNC-84 from C. elegans; SUN-domain proteins bind lamins and the KASH domain proteins of the outer nuclear membrane; SUN-1 along with the KASH-domain protein ZYG-12, is required for movement, homologous pairing and interhomolog recombination of chromosomes during meiosis; SUN-1 is a nuclear envelope receptor for CED-4 during apoptosis, and is bound by CED-4 in vitro; SUN-1 colocalizes with the nuclear lamin LMN-1 in vivo and binds it in vitro; SUN-1 is required for localization of the hook protein ZYG-12 to the nuclear envelope, and thus for the attachment of centrosomes to nuclei; SUN-1 is strongly expressed in the nuclear envelope of all early embryonic cells, the primordial germ cells Z2 and Z3, and the germ cell lineage (but not in sperm). | Paper_evidence | WBPaper00006310 | |||||
| WBPaper00006526 | |||||||||
| WBPaper00028444 | |||||||||
| WBPaper00030742 | |||||||||
| WBPaper00037842 | |||||||||
| WBPaper00035469 | |||||||||
| WBPaper00035200 | |||||||||
| WBPaper00040268 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 22 Mar 2012 00:00:00 | ||||||||
| Automated_description | Predicted to enable protein-membrane adaptor activity. Involved in several processes, including centrosome localization; embryo development; and regulation of centrosome duplication. Located in nuclear envelope. Expressed in several structures, including Caa; Psub4; Z2; Z3; and germ line. Human ortholog(s) of this gene implicated in spermatogenic failure 16. Is an ortholog of human SUN5 (Sad1 and UNC84 domain containing 5). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0070184 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16252) | ||||
| Modifies_disease | DOID:070355 | ||||||||
| Modifies_disease_in_annotation | WBDOannot00001299 | ||||||||
| WBDOannot00001303 | |||||||||
| Molecular_info | Corresponding_CDS | F57B1.2 | |||||||
| Corresponding_transcript | F57B1.2.1 | ||||||||
| Other_sequence | CRC04684_1 | ||||||||
| CBC04354_1 | |||||||||
| CJC04938_1 | |||||||||
| CRC02739_1 | |||||||||
| CRC01860_1 | |||||||||
| CR12446 | |||||||||
| CRC07700_1 | |||||||||
| CR05719 | |||||||||
| CR03069 | |||||||||
| CR00667 | |||||||||
| Associated_feature | WBsf1001751 | ||||||||
| WBsf1001752 | |||||||||
| WBsf1020677 | |||||||||
| WBsf234778 | |||||||||
| WBsf234779 | |||||||||
| Experimental_info | RNAi_result (17) | ||||||||
| Expr_pattern | Expr2947 | ||||||||
| Expr12820 | |||||||||
| Expr12832 | |||||||||
| Expr1025451 | |||||||||
| Expr1032551 | |||||||||
| Expr1152563 | |||||||||
| Expr2017122 | |||||||||
| Expr2035258 | |||||||||
| Drives_construct (16) | |||||||||
| Construct_product | WBCnstr00020276 | ||||||||
| WBCnstr00020352 | |||||||||
| WBCnstr00034399 | |||||||||
| Antibody | WBAntibody00000742 | ||||||||
| WBAntibody00000743 | |||||||||
| WBAntibody00000744 | |||||||||
| WBAntibody00001043 | |||||||||
| WBAntibody00001978 | |||||||||
| WBAntibody00002063 | |||||||||
| WBAntibody00002064 | |||||||||
| WBAntibody00002417 | |||||||||
| WBAntibody00002418 | |||||||||
| WBAntibody00002419 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (157) | |||||||||
| Interaction (204) | |||||||||
| Map_info | Map | V | Position | 4.98002 | Error | 0.00104 | |||
| Positive | Positive_clone | F57B1 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4713 | |||||||
| Pseudo_map_position | |||||||||
| Reference (66) | |||||||||
| Remark | Gene name created from parsing 'genotype' field from CGC strain information | CGC_data_submission | |||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
